DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation.

abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

journal_title：Cell reports

authors： Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

更新日期：2016-08-23 00:00:00

abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

journal_title：Cell reports

authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

更新日期：2016-09-13 00:00:00

abstract：:Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular...

journal_title：Cell reports

authors： Radonjić NV,Ayoub AE,Memi F,Yu X,Maroof A,Jakovcevski I,Anderson SA,Rakic P,Zecevic N

更新日期：2014-12-24 00:00:00

abstract：:The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we show that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration but, surprisingly, have preserved mitochondrial co...

journal_title：Cell reports

authors： Rowe GC,Patten IS,Zsengeller ZK,El-Khoury R,Okutsu M,Bampoh S,Koulisis N,Farrell C,Hirshman MF,Yan Z,Goodyear LJ,Rustin P,Arany Z

更新日期：2013-05-30 00:00:00

abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...

journal_title：Cell reports

authors： Kronforst MR,Hansen ME,Crawford NG,Gallant JR,Zhang W,Kulathinal RJ,Kapan DD,Mullen SP

更新日期：2013-11-14 00:00:00

abstract：:Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination,...

journal_title：Cell reports

authors： Jensen SK,Michaels NJ,Ilyntskyy S,Keough MB,Kovalchuk O,Yong VW

更新日期：2018-09-18 00:00:00

abstract：:Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated. Here, we confirm that diet-induced obesity promotes tumor growth in two murine colon cancer models and show that this effect is reversed by an orally administered controlled-release mitochondrial protonophore (CRMP)...

journal_title：Cell reports

authors： Wang Y,Nasiri AR,Damsky WE,Perry CJ,Zhang XM,Rabin-Court A,Pollak MN,Shulman GI,Perry RJ

更新日期：2018-07-03 00:00:00

abstract：:Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure. We report that DNA double-strand breaks (DSBs) provoke mutation hotspots via stress-induced mutation in Escherichia coli. With tet reporters placed 2 kb to 2 Mb (half...

journal_title：Cell reports

authors： Shee C,Gibson JL,Rosenberg SM

更新日期：2012-10-25 00:00:00

abstract：:Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor ...

journal_title：Cell reports

authors： Imanishi T,Unno M,Kobayashi W,Yoneda N,Akira S,Saito T

更新日期：2020-07-21 00:00:00

abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...

journal_title：Cell reports

authors： Rekaik H,Blaudin de Thé FX,Fuchs J,Massiani-Beaudoin O,Prochiantz A,Joshi RL

更新日期：2015-10-13 00:00:00

abstract：:The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be...

journal_title：Cell reports

authors： Nosi U,Lanner F,Huang T,Cox B

更新日期：2017-05-09 00:00:00

abstract：:Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA d...

journal_title：Cell reports

authors： Chen CF,Ruiz-Vega R,Vasudeva P,Espitia F,Krasieva TB,de Feraudy S,Tromberg BJ,Huang S,Garner CP,Wu J,Hoon DS,Ganesan AK

更新日期：2017-03-07 00:00:00

abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

journal_title：Cell reports

authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

更新日期：2018-08-28 00:00:00

abstract：:Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...

journal_title：Cell reports

authors： Kaushal S,Wollmuth CE,Das K,Hile SE,Regan SB,Barnes RP,Haouzi A,Lee SM,House NCM,Guyumdzhyan M,Eckert KA,Freudenreich CH

更新日期：2019-04-23 00:00:00

abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

journal_title：Cell reports

authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

更新日期：2019-11-19 00:00:00

abstract：:The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister chromatid cohesion and inactivation of Cyclin B/Cdk1, respectively. Thi...

journal_title：Cell reports

authors： Meadows JC,Lancaster TC,Buttrick GJ,Sochaj AM,Messin LJ,Del Mar Mora-Santos M,Hardwick KG,Millar JBA

更新日期：2017-02-07 00:00:00

abstract：:Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of endophilin-A mutant mi...

journal_title：Cell reports

authors： Murdoch JD,Rostosky CM,Gowrisankaran S,Arora AS,Soukup SF,Vidal R,Capece V,Freytag S,Fischer A,Verstreken P,Bonn S,Raimundo N,Milosevic I

更新日期：2016-10-18 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...

journal_title：Cell reports

authors： Li C,Wei Z,Fan Y,Huang W,Su Y,Li H,Dong Z,Fukuda M,Khater M,Wu G

更新日期：2017-10-24 00:00:00

abstract：:Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-...

journal_title：Cell reports

authors： Sheng J,Chen Q,Soncin I,Ng SL,Karjalainen K,Ruedl C

更新日期：2017-10-31 00:00:00

abstract：:Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secr...

journal_title：Cell reports

authors： Nyitrai H,Wang SSH,Kaeser PS

更新日期：2020-06-09 00:00:00

abstract：:The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized natu...

journal_title：Cell reports

authors： Invergo BM,Brochet M,Yu L,Choudhary J,Beltrao P,Billker O

更新日期：2017-11-14 00:00:00

abstract：:Most human cancers originate from high-turnover tissues, while low-proliferating tissues, like skeletal muscle, exhibit a lower incidence of tumor development. In Duchenne muscular dystrophy (DMD), which induces increased skeletal muscle regeneration, tumor incidence is increased. Rhabdomyosarcomas (RMSs), a rare and ...

journal_title：Cell reports

authors： Boscolo Sesillo F,Fox D,Sacco A

更新日期：2019-01-15 00:00:00

abstract：:We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked inhibitor of apoptosis). ARTS and Bcl-2 reside at the outer mitochondrial m...

journal_title：Cell reports

authors： Edison N,Curtz Y,Paland N,Mamriev D,Chorubczyk N,Haviv-Reingewertz T,Kfir N,Morgenstern D,Kupervaser M,Kagan J,Kim HT,Larisch S

更新日期：2017-10-10 00:00:00

abstract：:The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we ...

journal_title：Cell reports

authors： Johansson M,Chen J,Tsai A,Kornberg G,Puglisi JD

更新日期：2014-06-12 00:00:00

abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

journal_title：Cell reports

authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

更新日期：2018-03-20 00:00:00

abstract：:Protein isoforms generated by alternative splicing contribute to proteome diversity. Because of the lack of effective techniques, the isoform-specific function, expression, localization, and signaling of endogenous proteins are unknown for most genes. Here, we report a genetic method, isoTarget, for multi-purpose stud...

journal_title：Cell reports

authors： Liu H,Pizzano S,Li R,Zhao W,Veling MW,Hu Y,Yang L,Ye B

更新日期：2020-11-10 00:00:00

abstract：:The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium g...

journal_title：Cell reports

authors： Florentin A,Cobb DW,Fishburn JD,Cipriano MJ,Kim PS,Fierro MA,Striepen B,Muralidharan V

更新日期：2017-11-14 00:00:00

abstract：:5-hydroxymethylcytosine (5hmC) is enriched in brain and has been recognized as an important DNA modification. However, the roles of 5hmC and its writers, ten-eleven translocation (Tet) proteins, in stress-induced response have yet to be elucidated. Here, we show that chronic restraint stress (CRS) induced depression-l...

journal_title：Cell reports

authors： Cheng Y,Sun M,Chen L,Li Y,Lin L,Yao B,Li Z,Wang Z,Chen J,Miao Z,Xin N,Huang L,Allen EG,Wu H,Xu X,Jin P

更新日期：2018-12-11 00:00:00

abstract：:Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression o...

journal_title：Cell reports

authors： Chowdhury D,Alrefai H,Landero Figueroa JA,Candor K,Porollo A,Fecher R,Divanovic S,Deepe GS Jr,Subramanian Vignesh K

更新日期：2019-06-25 00:00:00

abstract：:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

journal_title：Cell reports

authors： Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

更新日期：2019-11-05 00:00:00