Diversity of cortical interneurons in primates: the role of the dorsal proliferative niche.

abstract：:We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked inhibitor of apoptosis). ARTS and Bcl-2 reside at the outer mitochondrial m...

journal_title：Cell reports

authors： Edison N,Curtz Y,Paland N,Mamriev D,Chorubczyk N,Haviv-Reingewertz T,Kfir N,Morgenstern D,Kupervaser M,Kagan J,Kim HT,Larisch S

更新日期：2017-10-10 00:00:00

abstract：:Glioblastoma (GBM) harbors subpopulations of therapy-resistant tumor-initiating cells (TICs) that are self-renewing and multipotent. To understand the regulation of the TIC state, we performed an image-based screen for genes regulating GBM TIC maintenance and identified ZFHX4, a 397 kDa transcription factor. ZFHX4 is ...

journal_title：Cell reports

authors： Chudnovsky Y,Kim D,Zheng S,Whyte WA,Bansal M,Bray MA,Gopal S,Theisen MA,Bilodeau S,Thiru P,Muffat J,Yilmaz OH,Mitalipova M,Woolard K,Lee J,Nishimura R,Sakata N,Fine HA,Carpenter AE,Silver SJ,Verhaak RG,Califano

更新日期：2014-01-30 00:00:00

abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...

journal_title：Cell reports

authors： Wang X,Yu R,Wang J,Lin Z,Han X,Deng Z,Fan L,He H,Deng XW,Chen H

更新日期：2020-04-21 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. We profiled microglia of a discrete developing CNS region, the murine ...

journal_title：Cell reports

authors： Anderson SR,Roberts JM,Zhang J,Steele MR,Romero CO,Bosco A,Vetter ML

更新日期：2019-05-14 00:00:00

abstract：:The multiple functions of lysosomes are critically dependent on their ability to undergo bidirectional movement along microtubules between the center and the periphery of the cell. Centrifugal and centripetal movement of lysosomes is mediated by kinesin and dynein motors, respectively. We recently described a multi-su...

journal_title：Cell reports

authors： Guardia CM,Farías GG,Jia R,Pu J,Bonifacino JS

更新日期：2016-11-15 00:00:00

abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...

journal_title：Cell reports

authors： Wang Y,Ku CJ,Zhang ER,Artyukhin AB,Weiner OD,Wu LF,Altschuler SJ

更新日期：2013-05-30 00:00:00

abstract：:Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit pr...

journal_title：Cell reports

authors： Yip SH,Romanò N,Gustafson P,Hodson DJ,Williams EJ,Kokay IC,Martin AO,Mollard P,Grattan DR,Bunn SJ

更新日期：2019-02-12 00:00:00

abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

journal_title：Cell reports

authors： Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

更新日期：2016-03-29 00:00:00

abstract：:Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein receptor 1α (BMPR1α) sustains expression of FOXP3 in Treg cells in periphera...

journal_title：Cell reports

authors： Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P

更新日期：2020-10-06 00:00:00

abstract：:Amyloidosis is a major problem in over one hundred diseases, including Alzheimer's disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation in the intact AD mouse brain at up to 27 months of age. We visualized am...

journal_title：Cell reports

authors： Liebmann T,Renier N,Bettayeb K,Greengard P,Tessier-Lavigne M,Flajolet M

更新日期：2016-07-26 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) and the spindle assembly checkpoint (SAC), which inhibits the APC/C, are essential determinants of mitotic timing and faithful division of genetic material. Activation of the APC/C is known to depend on two APC/C-interacting E2 ubiquitin-conjugating enzymes-UBE2C and UB...

journal_title：Cell reports

authors： Wild T,Larsen MS,Narita T,Schou J,Nilsson J,Choudhary C

更新日期：2016-03-01 00:00:00

abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

journal_title：Cell reports

authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

更新日期：2014-11-06 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate a causal link with another liability factor: low expressi...

journal_title：Cell reports

authors： Bocarsly ME,da Silva E Silva D,Kolb V,Luderman KD,Shashikiran S,Rubinstein M,Sibley DR,Dobbs LK,Alvarez VA

更新日期：2019-10-29 00:00:00

abstract：:Plant growth and development are defined by environmental cues. The transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is the central signaling hub that integrates environmental cues, including light and temperature, to regulate growth and development. The thermosensory mechanisms controlling the PIF4-mediat...

journal_title：Cell reports

authors： Gangappa SN,Kumar SV

更新日期：2017-01-10 00:00:00

abstract：:Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-confirmed ZIKV infection at early-acute, late-acute, and convalescent tim...

journal_title：Cell reports

authors： Michlmayr D,Kim EY,Rahman AH,Raghunathan R,Kim-Schulze S,Che Y,Kalayci S,Gümüş ZH,Kuan G,Balmaseda A,Kasarskis A,Wolinsky SM,Suaréz-Fariñas M,Harris E

更新日期：2020-04-28 00:00:00

abstract：:Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous studies reported that Caveolin-1 (Cav1) has both tumor-promoting and tumor-sup...

journal_title：Cell reports

authors： Celus W,Di Conza G,Oliveira AI,Ehling M,Costa BM,Wenes M,Mazzone M

更新日期：2017-12-05 00:00:00

abstract：:Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, and this may bias sub...

journal_title：Cell reports

authors： Wang L,Hiler D,Xu B,AlDiri I,Chen X,Zhou X,Griffiths L,Valentine M,Shirinifard A,Sablauer A,Thiagarajan S,Barabas ME,Zhang J,Johnson D,Frase S,Dyer MA

更新日期：2018-03-06 00:00:00

abstract：:Cell-cycle arrest in quiescence and senescence is largely orchestrated by the retinoblastoma (Rb) tumor-suppressor pathway, but the mechanisms underlying the quiescence-senescence switch remain unclear. Here, we show that the crosstalk between the Rb-AKT-signaling pathways forms this switch by controlling the overlapp...

journal_title：Cell reports

authors： Imai Y,Takahashi A,Hanyu A,Hori S,Sato S,Naka K,Hirao A,Ohtani N,Hara E

更新日期：2014-04-10 00:00:00

abstract：:Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in myocytes and endothelial cells. Whereas the regulators of proangiogenic factors are well defined (e.g., hypoxia-inducible factor [HIF]), the transcriptional pathways...

journal_title：Cell reports

authors： Yadav V,Matsakas A,Lorca S,Narkar VA

更新日期：2014-08-07 00:00:00

abstract：:Neural modulation in primate motor cortex exhibits complex patterns. We found that modulation during reaching could be separated into discrete temporal epochs. To determine if these epochs are driven by behavioral events, monkeys performed variations of a center-out reaching task. Monkeys viewed a computer cursor matc...

journal_title：Cell reports

authors： Suway SB,Schwartz AB

更新日期：2019-12-17 00:00:00

abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

journal_title：Cell reports

authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

更新日期：2018-06-05 00:00:00

abstract：:Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of coding genes of low ...

journal_title：Cell reports

authors： Parisien M,Khoury S,Chabot-Doré AJ,Sotocinal SG,Slade GD,Smith SB,Fillingim RB,Ohrbach R,Greenspan JD,Maixner W,Mogil JS,Belfer I,Diatchenko L

更新日期：2017-05-30 00:00:00

abstract：:The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apopt...

journal_title：Cell reports

authors： Burikhanov R,Shrestha-Bhattarai T,Hebbar N,Qiu S,Zhao Y,Zambetti GP,Rangnekar VM

更新日期：2014-01-30 00:00:00

abstract：:Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, espe...

journal_title：Cell reports

authors： Chandra V,Albagli-Curiel O,Hastoy B,Piccand J,Randriamampita C,Vaillant E,Cavé H,Busiah K,Froguel P,Vaxillaire M,Rorsman P,Polak M,Scharfmann R

更新日期：2014-12-24 00:00:00

abstract：:Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete fungicidal mechanisms are not fully understood. Here, we employ a systems biology approach to identify a common oxidative-damage cellular death pathway trigger...

journal_title：Cell reports

authors： Belenky P,Camacho D,Collins JJ

更新日期：2013-02-21 00:00:00

abstract：:The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within ...

journal_title：Cell reports

authors： Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

更新日期：2020-01-21 00:00:00

abstract：:In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell-autonomous events or t...

journal_title：Cell reports

authors： Simon CM,Janas AM,Lotti F,Tapia JC,Pellizzoni L,Mentis GZ

更新日期：2016-08-02 00:00:00

abstract：:Activation of CaV2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated CaV2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of phy...

journal_title：Cell reports

authors： Weyrer C,Turecek J,Niday Z,Liu PW,Nanou E,Catterall WA,Bean BP,Regehr WG

更新日期：2019-02-26 00:00:00