Abstract：
:Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit prolactin secretion and are activated by prolactin in a short-loop feedback manner. In lactation, dopamine synthesis is suppressed in an opioid-dependent (naloxone-reversible) manner, meaning that prolactin secretion is disinhibited. Conditional deletion of the prolactin receptor in neurons reveals that this change in phenotype appears to be driven by prolactin itself, apparently through an alteration in intracellular signaling downstream of the prolactin receptor that favors enkephalin production instead of dopamine. Thus, prolactin effectively facilitates its own secretion, which is essential for lactation and maternal behavior. These studies provide evidence of a physiologically important, reversible alteration in the behavior of a specific population of hypothalamic neurons in the adult brain.
journal_name
Cell Repjournal_title
Cell reportsauthors
Yip SH,Romanò N,Gustafson P,Hodson DJ,Williams EJ,Kokay IC,Martin AO,Mollard P,Grattan DR,Bunn SJdoi
10.1016/j.celrep.2019.01.067subject
Has Abstractpub_date
2019-02-12 00:00:00pages
1787-1799.e5issue
7issn
2211-1247pii
S2211-1247(19)30096-8journal_volume
26pub_type
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