PGC1β activates an antiangiogenic program to repress neoangiogenesis in muscle ischemia.

abstract：:Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK)...

journal_title：Cell reports

authors： Huang X,Li J,Dorta-Estremera S,Di Domizio J,Anthony SM,Watowich SS,Popkin D,Liu Z,Brohawn P,Yao Y,Schluns KS,Lanier LL,Cao W

更新日期：2015-08-18 00:00:00

abstract：:The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...

journal_title：Cell reports

authors： Ramirez PW,Famiglietti M,Sowrirajan B,DePaula-Silva AB,Rodesch C,Barker E,Bosque A,Planelles V

更新日期：2014-06-26 00:00:00

abstract：:The role of neurotrophic factors as endogenous survival proteins for brain neurons remains contentious. In the cerebellum, the signals controlling survival of molecular layer interneurons (MLIs) are unknown, and direct evidence for the requirement of a full complement of MLIs for normal cerebellar function and motor l...

journal_title：Cell reports

authors： Sergaki MC,López-Ramos JC,Stagkourakis S,Gruart A,Broberger C,Delgado-García JM,Ibáñez CF

更新日期：2017-06-06 00:00:00

abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...

journal_title：Cell reports

authors： Jin J,Valanejad L,Nguyen TP,Lewis K,Wright M,Cast A,Stock L,Timchenko L,Timchenko NA

更新日期：2016-07-19 00:00:00

abstract：:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

journal_title：Cell reports

authors： Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

更新日期：2019-11-05 00:00:00

abstract：:Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute carrier family (SLC) 7 member 5 (SLC7A5), and SLC43A1 constitute a fee...

journal_title：Cell reports

authors： Yue M,Jiang J,Gao P,Liu H,Qing G

更新日期：2017-12-26 00:00:00

abstract：:DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate th...

journal_title：Cell reports

authors： Lim CX,Lee B,Geiger O,Passegger C,Beitzinger M,Romberger J,Stracke A,Högenauer C,Stift A,Stoiber H,Poidinger M,Zebisch A,Meister G,Williams A,Flavell RA,Henao-Mejia J,Strobl H

更新日期：2020-03-17 00:00:00

abstract：:Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize...

journal_title：Cell reports

authors： Cheung CS,Fruehwirth A,Paparoditis PCG,Shen CH,Foglierini M,Joyce MG,Leung K,Piccoli L,Rawi R,Silacci-Fregni C,Tsybovsky Y,Verardi R,Wang L,Wang S,Yang ES,Zhang B,Zhang Y,Chuang GY,Corti D,Mascola JR,Shapiro L,K

更新日期：2020-09-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:The interferon (IFN)-induced transmembrane (IFITM) proteins are critical mediators of the host antiviral response. Here, we expand the role of IFITM proteins to host defense against intracellular bacterial infection by demonstrating that they restrict Mycobacterium tuberculosis (MTb) intracellular growth. Simultaneous...

journal_title：Cell reports

authors： Ranjbar S,Haridas V,Jasenosky LD,Falvo JV,Goldfeld AE

更新日期：2015-11-03 00:00:00

abstract：:Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus ac...

journal_title：Cell reports

authors： Avey D,Sankararaman S,Yim AKY,Barve R,Milbrandt J,Mitra RD

更新日期：2018-09-25 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...

journal_title：Cell reports

authors： Rupaimoole R,Lee J,Haemmerle M,Ling H,Previs RA,Pradeep S,Wu SY,Ivan C,Ferracin M,Dennison JB,Millward NMZ,Nagaraja AS,Gharpure KM,McGuire M,Sam N,Armaiz-Pena GN,Sadaoui NC,Rodriguez-Aguayo C,Calin GA,Drapkin RI,K

更新日期：2015-12-22 00:00:00

abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...

journal_title：Cell reports

authors： Romero-Pozuelo J,Figlia G,Kaya O,Martin-Villalba A,Teleman AA

更新日期：2020-04-14 00:00:00

abstract：:Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide. Here, we present a cryoelectron microscopy (cryo-EM) reconstruction at 3.8 Å resol...

journal_title：Cell reports

authors： Bischoff L,Berninghausen O,Beckmann R

更新日期：2014-10-23 00:00:00

abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...

journal_title：Cell reports

authors： Gerlach SU,Eichenlaub T,Herranz H

更新日期：2018-05-01 00:00:00

abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

journal_title：Cell reports

authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

更新日期：2020-06-30 00:00:00

abstract：:We report the emergence of an endogenous circadian clock that regulates organogenesis in mouse fetal kidney. We detect circadian rhythms both in vivo with transcriptional profiling and ex vivo by bioluminescence. High-resolution structural analysis of embryonic explants reveals that global or local clock disruption re...

journal_title：Cell reports

authors： Dan H,Ruan T,Sampogna RV

更新日期：2020-05-19 00:00:00

abstract：:CXCR5 is a key marker of follicular helper T (TFH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5- CD4+ T cells with TFH-cell-like features. This CXCR5- subset becomes expanded in severe HIV infection and is characterized by the upregulation of activation markers...

journal_title：Cell reports

authors： Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LF

更新日期：2019-09-17 00:00:00

abstract：:In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of cephalic NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, and the molecular mechanisms of this fat...

journal_title：Cell reports

authors： Arai HN,Sato F,Yamamoto T,Woltjen K,Kiyonari H,Yoshimoto Y,Shukunami C,Akiyama H,Kist R,Sehara-Fujisawa A

更新日期：2019-10-15 00:00:00

abstract：:Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engraft...

journal_title：Cell reports

authors： Diez JA,Arrojo E Drigo R,Zheng X,Stelmashenko OV,Chua M,Rodriguez-Diaz R,Fukuda M,Köhler M,Leibiger I,Tun SBB,Ali Y,Augustine GJ,Barathi VA,Berggren PO

更新日期：2017-08-08 00:00:00

abstract：:Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge. Here, we demonstrate a neuron-specific and region-targeted neural excitation s...

journal_title：Cell reports

authors： Qiu Z,Kala S,Guo J,Xian Q,Zhu J,Zhu T,Hou X,Wong KF,Yang M,Wang H,Sun L

更新日期：2020-08-18 00:00:00

abstract：:Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...

journal_title：Cell reports

authors： Oberle SG,Hanna-El-Daher L,Chennupati V,Enouz S,Scherer S,Prlic M,Zehn D

更新日期：2016-10-11 00:00:00

abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

journal_title：Cell reports

authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

更新日期：2019-11-19 00:00:00

abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

journal_title：Cell reports

authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

更新日期：2018-08-28 00:00:00

abstract：:Ependymomas exist within distinct genetic subgroups, but the molecular diversity within individual ependymomas is unknown. We perform multiplatform molecular profiling of 6 spatially distinct samples from an ependymoma with C11orf95-RELA fusion. DNA methylation and RNA sequencing distinguish clusters of samples accord...

journal_title：Cell reports

authors： Liu SJ,Magill ST,Vasudevan HN,Hilz S,Villanueva-Meyer JE,Lastella S,Daggubati V,Spatz J,Choudhury A,Orr BA,Demaree B,Seo K,Ferris SP,Abate AR,Oberheim Bush NA,Bollen AW,McDermott MW,Costello JF,Raleigh DR

更新日期：2020-02-04 00:00:00

abstract：:Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby contributing to learning and memory. To gain insight into the machinery controlling dendritic mRNA localization and translation, we established a stringent protocol to...

journal_title：Cell reports

authors： Fritzsche R,Karra D,Bennett KL,Ang FY,Heraud-Farlow JE,Tolino M,Doyle M,Bauer KE,Thomas S,Planyavsky M,Arn E,Bakosova A,Jungwirth K,Hörmann A,Palfi Z,Sandholzer J,Schwarz M,Macchi P,Colinge J,Superti-Furga G,Kiebl

更新日期：2013-12-26 00:00:00

abstract：:The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of Sox9. In regenerating kidneys, Sox9 expres...

journal_title：Cell reports

authors： Kang HM,Huang S,Reidy K,Han SH,Chinga F,Susztak K

更新日期：2016-02-02 00:00:00

abstract：:Cancer cell-derived secretomes have been documented to play critical roles in cancer progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved in various steps of tumor progression, which can offer strategies to fight cancer. Herein, we identify lung cancer progression-associate...

journal_title：Cell reports

authors： Wang C,Zhang S,Liu J,Tian Y,Ma B,Xu S,Fu Y,Luo Y

更新日期：2020-02-11 00:00:00

abstract：:Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genom...

journal_title：Cell reports

authors： Izzo A,Kamieniarz-Gdula K,Ramírez F,Noureen N,Kind J,Manke T,van Steensel B,Schneider R

更新日期：2013-06-27 00:00:00

abstract：:Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent alterations targetable by current drugs and need alternative, informed therapeutic options. To nominate potential targets, we performed a high-throughput small-...

journal_title：Cell reports

authors： Oberlick EM,Rees MG,Seashore-Ludlow B,Vazquez F,Nelson GM,Dharia NV,Weir BA,Tsherniak A,Ghandi M,Krill-Burger JM,Meyers RM,Wang X,Montgomery P,Root DE,Bieber JM,Radko S,Cheah JH,Hon CS,Shamji AF,Clemons PA,Park PJ

更新日期：2019-08-27 00:00:00