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Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Abstract：

:The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr) cells, a subset of suppressive Foxp3+ regulatory T cells located within GCs. Relatively little is known about the exact role of Tfr cells within the GC and how they exert their suppressive function. A unique feature of Tfr cells is their reported CXCR5-dependent localization to the GC. Here, we show that the lack of CXCR5 on Foxp3+ regulatory T cells results in a reduced frequency, but not an absence, of GC-localized Tfr cells. This reduction in Tfr cells is not sufficient to alter the magnitude or output of the GC response. This demonstrates that additional, CXCR5-independent mechanisms facilitate Treg cell homing to the GC.

journal_name

Cell Rep

journal_title

Cell reports

authors

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

doi

10.1016/j.celrep.2019.12.076

subject

Has Abstract

pub_date

2020-01-21 00:00:00

pages

611-619.e4

issue

3

issn

2211-1247

pii

S2211-1247(19)31741-3

journal_volume

30

pub_type

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