当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > The Asymmetric Expression of SAUR Genes Mediated by ARF7/19 Promotes the Gravitropism and Phototropism of Plant Hypocotyls.

The Asymmetric Expression of SAUR Genes Mediated by ARF7/19 Promotes the Gravitropism and Phototropism of Plant Hypocotyls.

Abstract：

:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their homologs in Arabidopsis. SAUR19 subfamily genes have asymmetric expression in Arabidopsis hypocotyls during gravitropic and phototropic responses, induced by the lateral redistribution of auxin. Both the mutation of SAUR19 subfamily genes and the ectopic expression of SAUR19 weaken these tropic responses, indicating the critical role of their asymmetric expression. The auxin-responsive transcription factor ARF7 may directly bind the SAUR19 promoter and activate SAUR19 expression asymmetrically in tropic responses. Taken together, our results reveal that a gravity- or light-triggered asymmetric auxin distribution induces the asymmetric expression of SAUR19 subfamily genes by ARF7 and ARF19 in the hypocotyls, which leads to bending growth during gravitropic and phototropic responses.

journal_name

Cell Rep

journal_title

Cell reports

authors

Wang X,Yu R,Wang J,Lin Z,Han X,Deng Z,Fan L,He H,Deng XW,Chen H

doi

10.1016/j.celrep.2020.107529

subject

Has Abstract

pub_date

2020-04-21 00:00:00

pages

107529

issue

3

issn

2211-1247

pii

S2211-1247(20)30429-0

journal_volume

31

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Adaptive Evolution of MERS-CoV to Species Variation in DPP4.

    abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood. Variation in the host receptor, dipeptidyl peptidase 4 (DPP4), can block the interaction with th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.045

    authors： Letko M,Miazgowicz K,McMinn R,Seifert SN,Sola I,Enjuanes L,Carmody A,van Doremalen N,Munster V

    更新日期：2018-08-14 00:00:00

  • Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.

    abstract：:Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108345

    authors： Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

    更新日期：2020-11-03 00:00:00

  • Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep.

    abstract：:It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.037

    authors： Schreiner T,Doeller CF,Jensen O,Rasch B,Staudigl T

    更新日期：2018-10-09 00:00:00

  • Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy.

    abstract：:Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult patients. We found pronounced RNA toxicity in the Bergmann glia of t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.06.006

    authors： Sicot G,Servais L,Dinca DM,Leroy A,Prigogine C,Medja F,Braz SO,Huguet-Lachon A,Chhuon C,Nicole A,Gueriba N,Oliveira R,Dan B,Furling D,Swanson MS,Guerrera IC,Cheron G,Gourdon G,Gomes-Pereira M

    更新日期：2017-06-27 00:00:00

  • Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells.

    abstract：:Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the response of tumor-specific...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.131

    authors： Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R

    更新日期：2019-12-03 00:00:00

  • Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila.

    abstract：:Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although their choosiness toward egg-laying sites is well documented, the specific neural mechanism that activates females' search for attractive egg-laying sites is not known. Here, we show that distention and con...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.09.033

    authors： Gou B,Liu Y,Guntur AR,Stern U,Yang CH

    更新日期：2014-10-23 00:00:00

  • Role of DNA Methylation in Modulating Transcription Factor Occupancy.

    abstract：:Although DNA methylation is commonly invoked as a mechanism for transcriptional repression, the extent to which it actively silences transcription factor (TF) occupancy sites in vivo is unknown. To study the role of DNA methylation in the active modulation of TF binding, we quantified the effect of DNA methylation dep...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.024

    authors： Maurano MT,Wang H,John S,Shafer A,Canfield T,Lee K,Stamatoyannopoulos JA

    更新日期：2015-08-18 00:00:00

  • Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers.

    abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107929

    authors： Thiecke MJ,Wutz G,Muhar M,Tang W,Bevan S,Malysheva V,Stocsits R,Neumann T,Zuber J,Fraser P,Schoenfelder S,Peters JM,Spivakov M

    更新日期：2020-07-21 00:00:00

  • PGC1β activates an antiangiogenic program to repress neoangiogenesis in muscle ischemia.

    abstract：:Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in myocytes and endothelial cells. Whereas the regulators of proangiogenic factors are well defined (e.g., hypoxia-inducible factor [HIF]), the transcriptional pathways...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.040

    authors： Yadav V,Matsakas A,Lorca S,Narkar VA

    更新日期：2014-08-07 00:00:00

  • Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

    abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108316

    authors： Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

    更新日期：2020-10-27 00:00:00

  • FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.

    abstract：:Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data. Here, we describe a method for isolating large numbers of pure NBs and differentiating neurons that retain both cell-cycle and lineage cha...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.07.008

    authors： Berger C,Harzer H,Burkard TR,Steinmann J,van der Horst S,Laurenson AS,Novatchkova M,Reichert H,Knoblich JA

    更新日期：2012-08-30 00:00:00

  • Color Categorization Independent of Color Naming.

    abstract：:Color is continuous, yet we group colors into discrete categories associated with color names (e.g., yellow, blue). Color categorization is a case in point in the debate on how language shapes human cognition. Evidence suggests that color categorization depends on top-down input from the language system to the visual ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.08.003

    authors： Siuda-Krzywicka K,Witzel C,Chabani E,Taga M,Coste C,Cools N,Ferrieux S,Cohen L,Seidel Malkinson T,Bartolomeo P

    更新日期：2019-09-03 00:00:00

  • Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs.

    abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.062

    authors： Firth AL,Menon T,Parker GS,Qualls SJ,Lewis BM,Ke E,Dargitz CT,Wright R,Khanna A,Gage FH,Verma IM

    更新日期：2015-09-01 00:00:00

  • CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.

    abstract：:Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activit...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.10.077

    authors： Johnson SF,Cruz C,Greifenberg AK,Dust S,Stover DG,Chi D,Primack B,Cao S,Bernhardy AJ,Coulson R,Lazaro JB,Kochupurakkal B,Sun H,Unitt C,Moreau LA,Sarosiek KA,Scaltriti M,Juric D,Baselga J,Richardson AL,Rodig SJ,D

    更新日期：2016-11-22 00:00:00

  • The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.

    abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.078

    authors： Camacho J,Truong L,Kurt Z,Chen YW,Morselli M,Gutierrez G,Pellegrini M,Yang X,Allard P

    更新日期：2018-05-22 00:00:00

  • Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics.

    abstract：:The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption r...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.012

    authors： Brinkkoetter PT,Bork T,Salou S,Liang W,Mizi A,Özel C,Koehler S,Hagmann HH,Ising C,Kuczkowski A,Schnyder S,Abed A,Schermer B,Benzing T,Kretz O,Puelles VG,Lagies S,Schlimpert M,Kammerer B,Handschin C,Schell C,Hube

    更新日期：2019-04-30 00:00:00

  • Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.

    abstract：:Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108088

    authors： Cheung CS,Fruehwirth A,Paparoditis PCG,Shen CH,Foglierini M,Joyce MG,Leung K,Piccoli L,Rawi R,Silacci-Fregni C,Tsybovsky Y,Verardi R,Wang L,Wang S,Yang ES,Zhang B,Zhang Y,Chuang GY,Corti D,Mascola JR,Shapiro L,K

    更新日期：2020-09-01 00:00:00

  • Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.

    abstract：:Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. However, the role of NBEA...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.112

    authors： Gromova KV,Muhia M,Rothammer N,Gee CE,Thies E,Schaefer I,Kress S,Kilimann MW,Shevchuk O,Oertner TG,Kneussel M

    更新日期：2018-05-29 00:00:00

  • Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes.

    abstract：:CXCR5 is a key marker of follicular helper T (TFH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5- CD4+ T cells with TFH-cell-like features. This CXCR5- subset becomes expanded in severe HIV infection and is characterized by the upregulation of activation markers...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.08.037

    authors： Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LF

    更新日期：2019-09-17 00:00:00

  • Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.

    abstract：:Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). Howev...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107579

    authors： Sato H,Taketomi Y,Miki Y,Murase R,Yamamoto K,Murakami M

    更新日期：2020-05-05 00:00:00

  • Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.

    abstract：:RAS family GTPases contribute directly to the regulation of type I phosphoinositide 3-kinases (PI3Ks) via RAS-binding domains in the PI3K catalytic p110 subunits. Disruption of this domain of p110α impairs RAS-mutant-oncogene-driven tumor formation and maintenance. Here, we test the effect of blocking the interaction ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.003

    authors： Murillo MM,Rana S,Spencer-Dene B,Nye E,Stamp G,Downward J

    更新日期：2018-12-26 00:00:00

  • Discovery and Characterization of piRNAs in the Human Fetal Ovary.

    abstract：:Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.030

    authors： Williams Z,Morozov P,Mihailovic A,Lin C,Puvvula PK,Juranek S,Rosenwaks Z,Tuschl T

    更新日期：2015-10-27 00:00:00

  • The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.

    abstract：:Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expre...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.075

    authors： Merienne N,Vachey G,de Longprez L,Meunier C,Zimmer V,Perriard G,Canales M,Mathias A,Herrgott L,Beltraminelli T,Maulet A,Dequesne T,Pythoud C,Rey M,Pellerin L,Brouillet E,Perrier AL,du Pasquier R,Déglon N

    更新日期：2017-09-19 00:00:00

  • Global scaling down of excitatory postsynaptic responses in cerebellar Purkinje cells impairs developmental synapse elimination.

    abstract：:Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to Purkinje cell (PC) synapse elimination in the cerebellum. We genera...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.014

    authors： Kawata S,Miyazaki T,Yamazaki M,Mikuni T,Yamasaki M,Hashimoto K,Watanabe M,Sakimura K,Kano M

    更新日期：2014-08-21 00:00:00

  • The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes.

    abstract：:Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.037

    authors： Xing F,Luan Y,Cai J,Wu S,Mai J,Gu J,Zhang H,Li K,Lin Y,Xiao X,Liang J,Li Y,Chen W,Tan Y,Sheng L,Lu B,Lu W,Gao M,Qiu P,Su X,Yin W,Hu J,Chen Z,Sai K,Wang J,Chen F,Chen Y,Zhu S,Liu D,Cheng S,Xie Z

    更新日期：2017-01-10 00:00:00

  • Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.

    abstract：:The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister chromatid cohesion and inactivation of Cyclin B/Cdk1, respectively. Thi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.01.032

    authors： Meadows JC,Lancaster TC,Buttrick GJ,Sochaj AM,Messin LJ,Del Mar Mora-Santos M,Hardwick KG,Millar JBA

    更新日期：2017-02-07 00:00:00

  • The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.

    abstract：:We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. We identify kinase-dependent roles for HPK1 in CD8 T cells that restrict their anti-viral and anti-tumor...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.012

    authors： Hernandez S,Qing J,Thibodeau RH,Du X,Park S,Lee HM,Xu M,Oh S,Navarro A,Roose-Girma M,Newman RJ,Warming S,Nannini M,Sampath D,Kim JM,Grogan JL,Mellman I

    更新日期：2018-10-02 00:00:00

  • Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

    abstract：:MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, the mechanisms whereby miRNAs are sorted to exosomes and the significance of miRNA transfer to acceptor cells are unclear. We used macrophage...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.035

    authors： Squadrito ML,Baer C,Burdet F,Maderna C,Gilfillan GD,Lyle R,Ibberson M,De Palma M

    更新日期：2014-09-11 00:00:00

  • MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data.

    abstract：:While meta-analysis has demonstrated increased statistical power and more robust estimations in studies, the application of this commonly accepted methodology to cytometry data has been challenging. Different cytometry studies often involve diverse sets of markers. Moreover, the detected values of the same marker are ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.003

    authors： Hu Z,Jujjavarapu C,Hughey JJ,Andorf S,Lee HC,Gherardini PF,Spitzer MH,Thomas CG,Campbell J,Dunn P,Wiser J,Kidd BA,Dudley JT,Nolan GP,Bhattacharya S,Butte AJ

    更新日期：2018-07-31 00:00:00

  • Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.

    abstract：:Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly reduced or even abs...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.06.080

    authors： Costa RO,Martins H,Martins LF,Cwetsch AW,Mele M,Pedro JR,Tomé D,Jeon NL,Cancedda L,Jaffrey SR,Almeida RD

    更新日期：2019-07-23 00:00:00