Abstract:
:Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and high expression of interferon regulated genes (IRGs). CRISPR knockout (KO) of IRF 1/3/7 in cells reveals distinct subsets of genes affected by each IRF in an IFN-ligand signaling-dependent and largely independent manner. As the master regulators of innate immunity, the IRFs control the kinetics and maintenance of the IRG response and play essential roles in response to influenza A virus (IAV), herpes simplex virus 1 (HSV-1), Melaka virus/Pteropine orthoreovirus 3 Melaka (PRV3M), and Middle East respiratory syndrome-related coronavirus (MERS-CoV) infection. With its differential expression in bats compared to that in humans, this highlights a critical role for basal IRF expression in viral responses and potentially immune cell development in bats with relevance for IRF function in human biology.
journal_name
Cell Repjournal_title
Cell reportsauthors
Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LFdoi
10.1016/j.celrep.2020.108345subject
Has Abstractpub_date
2020-11-03 00:00:00pages
108345issue
5issn
2211-1247pii
S2211-1247(20)31334-6journal_volume
33pub_type
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