当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.

Abstract：

:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes the derepression of an epigenomically silenced transgene in the germline for 5 generations, regardless of ancestral response. Chromatin immunoprecipitation sequencing (ChIP-seq), histone modification quantitation, and immunofluorescence assays revealed that this effect is associated with a reduction of the repressive marks H3K9me3 and H3K27me3 in whole worms and in germline nuclei in the F3, as well as with reproductive dysfunctions, including germline apoptosis and embryonic lethality. Furthermore, targeting of the Jumonji demethylases JMJD-2 and JMJD-3/UTX-1 restores H3K9me3 and H3K27me3 levels, respectively, and it fully alleviates the BPA-induced transgenerational effects. Together, our results demonstrate the central role of repressive histone modifications in the inheritance of reproductive defects elicited by a common environmental chemical exposure.

journal_name

Cell Rep

journal_title

Cell reports

authors

Camacho J,Truong L,Kurt Z,Chen YW,Morselli M,Gutierrez G,Pellegrini M,Yang X,Allard P

doi

10.1016/j.celrep.2018.04.078

subject

Has Abstract

pub_date

2018-05-22 00:00:00

pages

2392-2404

issue

8

issn

2211-1247

pii

S2211-1247(18)30637-5

journal_volume

23

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes.

    abstract：:DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molec...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.12.022

    authors： Vlijm R,Lee M,Lipfert J,Lusser A,Dekker C,Dekker NH

    更新日期：2015-01-13 00:00:00

  • Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

    abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.09.026

    authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

    更新日期：2012-11-29 00:00:00

  • YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.

    abstract：:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.04.075

    authors： Qiao Y,Chen J,Lim YB,Finch-Edmondson ML,Seshachalam VP,Qin L,Jiang T,Low BC,Singh H,Lim CT,Sudol M

    更新日期：2017-05-23 00:00:00

  • A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection.

    abstract：:The interferon (IFN)-induced transmembrane (IFITM) proteins are critical mediators of the host antiviral response. Here, we expand the role of IFITM proteins to host defense against intracellular bacterial infection by demonstrating that they restrict Mycobacterium tuberculosis (MTb) intracellular growth. Simultaneous...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.048

    authors： Ranjbar S,Haridas V,Jasenosky LD,Falvo JV,Goldfeld AE

    更新日期：2015-11-03 00:00:00

  • Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance.

    abstract：:Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in intestinal adenomas, but not in the normal intestine. Using in vivo model...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.08.034

    authors： Wiener Z,Högström J,Hyvönen V,Band AM,Kallio P,Holopainen T,Dufva O,Haglund C,Kruuna O,Oliver G,Ben-Neriah Y,Alitalo K

    更新日期：2014-09-25 00:00:00

  • Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.

    abstract：:Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.024

    authors： Leon J,Moreno AJ,Garay BI,Chalkley RJ,Burlingame AL,Wang D,Dubal DB

    更新日期：2017-08-08 00:00:00

  • Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.

    abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.11.023

    authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

    更新日期：2013-01-31 00:00:00

  • T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells.

    abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.06.074

    authors： Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

    更新日期：2018-07-24 00:00:00

  • Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.

    abstract：:Sex differences in autoimmunity and infection suggest that a better understanding of molecular sex differences will improve the diagnosis and treatment of immune-related disease. We identified 144 differentially expressed genes, referred to as immune sex expression signature (iSEXS), between human males and females us...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.019

    authors： Bongen E,Lucian H,Khatri A,Fragiadakis GK,Bjornson ZB,Nolan GP,Utz PJ,Khatri P

    更新日期：2019-11-12 00:00:00

  • Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription.

    abstract：:Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized mechanism of transcription interference. Here, we propose a comprehensive model ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107612

    authors： Gill JK,Maffioletti A,García-Molinero V,Stutz F,Soudet J

    更新日期：2020-05-05 00:00:00

  • Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase.

    abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.018

    authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

    更新日期：2015-12-22 00:00:00

  • Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

    abstract：:RNA polymerase II transcripts receive a protective 5',5'-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay. Alternative RNA caps can be acquired when transcription initiation uses metabolites like nicotinamide adenine dinucleotide (N...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.108

    authors： Wu H,Li L,Chen KM,Homolka D,Gos P,Fleury-Olela F,McCarthy AA,Pillai RS

    更新日期：2019-12-24 00:00:00

  • Functional genomic analysis of human mitochondrial RNA processing.

    abstract：:Both strands of human mtDNA are transcribed in continuous, multigenic units that are cleaved into the mature rRNAs, tRNAs, and mRNAs required for respiratory chain biogenesis. We sought to systematically identify nuclear-encoded proteins that contribute to processing of mtRNAs within the organelle. First, we devised a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.035

    authors： Wolf AR,Mootha VK

    更新日期：2014-05-08 00:00:00

  • Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle.

    abstract：:In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity and selectivity of Pap1 activation by peroxides are not fully understood. Here, we demonstra...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.11.027

    authors： Calvo IA,Boronat S,Domènech A,García-Santamarina S,Ayté J,Hidalgo E

    更新日期：2013-12-12 00:00:00

  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.

    abstract：:Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe char...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.010

    authors： Beerman RW,Matty MA,Au GG,Looger LL,Choudhury KR,Keller PJ,Tobin DM

    更新日期：2015-12-15 00:00:00

  • Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.

    abstract：:Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, we show that brain-produced IL-6 is decreased in obese mice and rats in a neuroanatomically and sex...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.044

    authors： Mishra D,Richard JE,Maric I,Porteiro B,Häring M,Kooijman S,Musovic S,Eerola K,López-Ferreras L,Peris E,Grycel K,Shevchouk OT,Micallef P,Olofsson CS,Wernstedt Asterholm I,Grill HJ,Nogueiras R,Skibicka KP

    更新日期：2019-03-12 00:00:00

  • Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.

    abstract：:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.069

    authors： Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

    更新日期：2017-03-21 00:00:00

  • XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.

    abstract：:Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. Here, we report that elevation of ER stress above a critical threshold causes ac...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.013

    authors： Fink EE,Moparthy S,Bagati A,Bianchi-Smiraglia A,Lipchick BC,Wolff DW,Roll MV,Wang J,Liu S,Bakin AV,Kandel ES,Lee AH,Nikiforov MA

    更新日期：2018-10-02 00:00:00

  • Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure.

    abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.006

    authors： Gerlach SU,Eichenlaub T,Herranz H

    更新日期：2018-05-01 00:00:00

  • APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.

    abstract：:APOBEC family cytidine deaminases have recently been implicated as powerful mutators of cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to chromosomal DNA is unclear. To ascertain the chromosomal ssDNA substrates of the APOBECs, we expressed APOBEC3A and APOBEC3B, the two most probable APOBE...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.021

    authors： Hoopes JI,Cortez LM,Mertz TM,Malc EP,Mieczkowski PA,Roberts SA

    更新日期：2016-02-16 00:00:00

  • Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease.

    abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108304

    authors： Fiorentino A,Christophorou A,Massa F,Garbay S,Chiral M,Ramsing M,Rasmussen M,Gubler MC,Bessieres B,Heidet L,Fischer E,Pontoglio M

    更新日期：2020-10-27 00:00:00

  • Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.

    abstract：:Glycophosphatidylinositol-anchored proteins (GPI-APs) play essential roles in physiology, but their biogenesis and trafficking have not been systematically characterized. Here, we took advantage of the recently available haploid genetics approach to dissect GPI-AP pathways in human cells using prion protein (PrP) and ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.05.026

    authors： Davis EM,Kim J,Menasche BL,Sheppard J,Liu X,Tan AC,Shen J

    更新日期：2015-06-23 00:00:00

  • Cortical Polarity of the RING Protein PAR-2 Is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary.

    abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.07.047

    authors： Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

    更新日期：2016-08-23 00:00:00

  • Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.

    abstract：:Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conform...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107735

    authors： Polenghi A,Nieus T,Guazzi S,Gorostiza P,Petrini EM,Barberis A

    更新日期：2020-06-09 00:00:00

  • Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication.

    abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.020

    authors： Zhang K,Lv DW,Li R

    更新日期：2019-07-09 00:00:00

  • Principles of bacterial cell-size determination revealed by cell-wall synthesis perturbations.

    abstract：:Although bacterial cell morphology is tightly controlled, the principles of size regulation remain elusive. In Escherichia coli, perturbation of cell-wall synthesis often results in similar morphologies, making it difficult to deconvolve the complex genotype-phenotype relationships underlying morphogenesis. Here we mo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.027

    authors： Tropini C,Lee TK,Hsin J,Desmarais SM,Ursell T,Monds RD,Huang KC

    更新日期：2014-11-20 00:00:00

  • Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity.

    abstract：:Glioblastoma (GBM) is highly refractory to therapy and associated with poor clinical outcome. Here, we reveal a critical function of the promitotic and adhesion-mediating discoidin domain receptor 1 (DDR1) in modulating GBM therapy resistance. In GBM cultures and clinical samples, we show a DDR1 and GBM stem cell mark...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.096

    authors： Vehlow A,Klapproth E,Jin S,Hannen R,Hauswald M,Bartsch JW,Nimsky C,Temme A,Leitinger B,Cordes N

    更新日期：2019-03-26 00:00:00

  • A Regulatory Program for Initiation of Wnt Signaling during Posterior Regeneration.

    abstract：:Whole-body regeneration relies on the re-establishment of body axes for patterning of new tissue. Wnt signaling is required to correctly regenerate tissues along the primary axis in many animals. However, the causal mechanisms that first launch Wnt signaling during regeneration are poorly characterized. We use the aco...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108098

    authors： Ramirez AN,Loubet-Senear K,Srivastava M

    更新日期：2020-09-01 00:00:00

  • Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

    abstract：:Ubiquitin is post-translationally modified by phosphorylation at several sites, but the consequences of these modifications are largely unknown. Here, we synthesize multi-milligram quantities of ubiquitin phosphorylated at serine 20, serine 57, and serine 65 via genetic code expansion. We use these phosphoubiquitins f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.06.064

    authors： Huguenin-Dezot N,De Cesare V,Peltier J,Knebel A,Kristaryianto YA,Rogerson DT,Kulathu Y,Trost M,Chin JW

    更新日期：2016-07-26 00:00:00

  • A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.

    abstract：:SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.002

    authors： Ritho J,Arold ST,Yeh ET

    更新日期：2015-08-04 00:00:00