Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes.

abstract：:Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property chan...

journal_title：Cell reports

authors： Grimsholm O,Piano Mortari E,Davydov AN,Shugay M,Obraztsova AS,Bocci C,Marasco E,Marcellini V,Aranburu A,Farroni C,Silvestris DA,Cristofoletti C,Giorda E,Scarsella M,Cascioli S,Barresi S,Lougaris V,Plebani A,Cancrini C

更新日期：2020-03-03 00:00:00

abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

journal_title：Cell reports

authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

更新日期：2019-11-19 00:00:00

abstract：:The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium g...

journal_title：Cell reports

authors： Florentin A,Cobb DW,Fishburn JD,Cipriano MJ,Kim PS,Fierro MA,Striepen B,Muralidharan V

更新日期：2017-11-14 00:00:00

abstract：:Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknow...

journal_title：Cell reports

authors： Adomati T,Cham LB,Hamdan TA,Bhat H,Duhan V,Li F,Ali M,Lang E,Huang A,Naser E,Khairnar V,Friedrich SK,Lang J,Friebus-Kardash J,Bergerhausen M,Schiller M,Machlah YM,Lang F,Häussinger D,Ferencik S,Hardt C,Lang PA,

更新日期：2020-03-17 00:00:00

abstract：:In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da ne...

journal_title：Cell reports

authors： Guo Y,Wang Y,Wang Q,Wang Z

更新日期：2014-11-20 00:00:00

abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...

journal_title：Cell reports

authors： Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM

更新日期：2020-03-24 00:00:00

abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

journal_title：Cell reports

authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

更新日期：2013-01-31 00:00:00

abstract：:The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms t...

journal_title：Cell reports

authors： Unno J,Itaya A,Taoka M,Sato K,Tomida J,Sakai W,Sugasawa K,Ishiai M,Ikura T,Isobe T,Kurumizaka H,Takata M

更新日期：2014-05-22 00:00:00

abstract：:The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster CNS. Using Targeted DamID...

journal_title：Cell reports

authors： Vissers JHA,Froldi F,Schröder J,Papenfuss AT,Cheng LY,Harvey KF

更新日期：2018-11-06 00:00:00

abstract：:Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology remain elusive. Here, we characterized axon-targeted delivery of degradative ...

journal_title：Cell reports

authors： Farfel-Becker T,Roney JC,Cheng XT,Li S,Cuddy SR,Sheng ZH

更新日期：2019-07-02 00:00:00

abstract：:Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity of TRIM5α is thought to be limited to retroviruses as a result of highly specific interactions with capsid lattices. In contrast to this current understanding, w...

journal_title：Cell reports

authors： Chiramel AI,Meyerson NR,McNally KL,Broeckel RM,Montoya VR,Méndez-Solís O,Robertson SJ,Sturdevant GL,Lubick KJ,Nair V,Youseff BH,Ireland RM,Bosio CM,Kim K,Luban J,Hirsch VM,Taylor RT,Bouamr F,Sawyer SL,Best SM

更新日期：2019-06-11 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...

journal_title：Cell reports

authors： Williams Z,Morozov P,Mihailovic A,Lin C,Puvvula PK,Juranek S,Rosenwaks Z,Tuschl T

更新日期：2015-10-27 00:00:00

abstract：:Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of single gene mutations' non-tissue-specific "core transcriptome signatures...

journal_title：Cell reports

authors： Xu C,Ai D,Shi D,Suo S,Chen X,Yan Y,Cao Y,Zhang R,Sun N,Chen W,McDermott J,Zhang S,Zeng Y,Han JJ

更新日期：2018-10-09 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Emerging studies have begun to demonstrate that reprogrammed stromal cells play pivotal roles in tumor growth, metastasis, and resistance to therapy. However, the contribution of stromal cells to non-small-cell lung cancer (NSCLC) has remained underexplored. We used an orthotopic model of Kras-driven NSCLC to systemat...

journal_title：Cell reports

authors： Choi H,Sheng J,Gao D,Li F,Durrans A,Ryu S,Lee SB,Narula N,Rafii S,Elemento O,Altorki NK,Wong ST,Mittal V

更新日期：2015-02-24 00:00:00

abstract：:The activation of G-protein-coupled receptors (GPCRs) leads to the activation of mTORC2 in cell migration and metabolism. However, the mechanism that links GPCRs to mTORC2 remains unknown. Here, using Dictyostelium cells, we show that GPCR-mediated chemotactic stimulation induces hetero-oligomerization of phosphorylat...

journal_title：Cell reports

authors： Senoo H,Wai M,Matsubayashi HT,Sesaki H,Iijima M

更新日期：2020-11-24 00:00:00

abstract：:Huntington's disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization (FISH) method, we ...

journal_title：Cell reports

authors： Didiot MC,Ferguson CM,Ly S,Coles AH,Smith AO,Bicknell AA,Hall LM,Sapp E,Echeverria D,Pai AA,DiFiglia M,Moore MJ,Hayward LJ,Aronin N,Khvorova A

更新日期：2018-09-04 00:00:00

abstract：:Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extr...

journal_title：Cell reports

authors： Zhao H,Michelot A,Koskela EV,Tkach V,Stamou D,Drubin DG,Lappalainen P

更新日期：2013-09-26 00:00:00

abstract：:Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...

journal_title：Cell reports

authors： Coultrap SJ,Freund RK,O'Leary H,Sanderson JL,Roche KW,Dell'Acqua ML,Bayer KU

更新日期：2014-02-13 00:00:00

abstract：:Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its combination with l...

journal_title：Cell reports

authors： Mills BN,Connolly KA,Ye J,Murphy JD,Uccello TP,Han BJ,Zhao T,Drage MG,Murthy A,Qiu H,Patel A,Figueroa NM,Johnston CJ,Prieto PA,Egilmez NK,Belt BA,Lord EM,Linehan DC,Gerber SA

更新日期：2019-10-08 00:00:00

abstract：:Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

journal_title：Cell reports

authors： Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

更新日期：2019-07-30 00:00:00

abstract：:DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molec...

journal_title：Cell reports

authors： Vlijm R,Lee M,Lipfert J,Lusser A,Dekker C,Dekker NH

更新日期：2015-01-13 00:00:00

abstract：:The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...

journal_title：Cell reports

authors： Liu H,Li L,Wang W,Gong J,Yang X,Hu Z

更新日期：2018-02-27 00:00:00

abstract：:In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficient cells exhibit a c...

journal_title：Cell reports

authors： Tadi SK,Tellier-Lebègue C,Nemoz C,Drevet P,Audebert S,Roy S,Meek K,Charbonnier JB,Modesti M

更新日期：2016-10-04 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...

journal_title：Cell reports

authors： Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

更新日期：2018-07-10 00:00:00

abstract：:Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studie...

journal_title：Cell reports

authors： Selvadurai HJ,Luis E,Desai K,Lan X,Vladoiu MC,Whitley O,Galvin C,Vanner RJ,Lee L,Whetstone H,Kushida M,Nowakowski T,Diamandis P,Hawkins C,Bader G,Kriegstein A,Taylor MD,Dirks PB

更新日期：2020-04-14 00:00:00

abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...

journal_title：Cell reports

authors： Thiecke MJ,Wutz G,Muhar M,Tang W,Bevan S,Malysheva V,Stocsits R,Neumann T,Zuber J,Fraser P,Schoenfelder S,Peters JM,Spivakov M

更新日期：2020-07-21 00:00:00

abstract：:Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation. However, the role of other neurotransmitters in BAT homeostasis remains largely...

journal_title：Cell reports

authors： Ikegami R,Shimizu I,Sato T,Yoshida Y,Hayashi Y,Suda M,Katsuumi G,Li J,Wakasugi T,Minokoshi Y,Okamoto S,Hinoi E,Nielsen S,Jespersen NZ,Scheele C,Soga T,Minamino T

更新日期：2018-09-11 00:00:00

abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...

journal_title：Cell reports

authors： Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz A

更新日期：2013-06-27 00:00:00