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Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.

Abstract：

:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same transcription factors that regulate the spatial pattern of cdc25(string) transcription encode its temporal activation. We identify buttonhead and empty spiracles as the major activators of cdc25(string) expression in mitotic domain 2. The effect of these activators is balanced through repression by hairy, sloppy paired 1, and huckebein. Within the mitotic domain, temporal precision of mitosis is robust and unaffected by changing dosage of rate-limiting transcriptional factors. However, precision can be disrupted by altering the levels of the two activators or two repressors. We propose that the additive and balanced action of activators and repressors is a general strategy for precise temporal regulation of cellular transitions during development.

journal_name

Cell Rep

journal_title

Cell reports

authors

Momen-Roknabadi A,Di Talia S,Wieschaus E

doi

10.1016/j.celrep.2016.08.034

subject

Has Abstract

pub_date

2016-09-13 00:00:00

pages

2793-2801

issue

11

issn

2211-1247

pii

S2211-1247(16)31098-1

journal_volume

16

pub_type

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