Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans.

abstract：:α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

journal_title：Cell reports

authors： Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

更新日期：2017-12-05 00:00:00

abstract：:Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1. We show here that, in both fission yeasts and humans, Mpn1 processes the spliceosomal U6 small nuclear RNA (snRNA) posttranscriptionally. In Mpn...

journal_title：Cell reports

authors： Shchepachev V,Wischnewski H,Missiaglia E,Soneson C,Azzalin CM

更新日期：2012-10-25 00:00:00

abstract：:Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein receptor 1α (BMPR1α) sustains expression of FOXP3 in Treg cells in periphera...

journal_title：Cell reports

authors： Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P

更新日期：2020-10-06 00:00:00

abstract：:Striatal medium-sized spiny neurons (MSNs), composed of striatonigral and striatopallidal neurons, are derived from the lateral ganglionic eminence (LGE). We find that the transcription factor Sp9 is expressed in LGE progenitors that generate nearly all striatal MSNs and that Sp9 expression is maintained in postmitoti...

journal_title：Cell reports

authors： Zhang Q,Zhang Y,Wang C,Xu Z,Liang Q,An L,Li J,Liu Z,You Y,He M,Mao Y,Chen B,Xiong ZQ,Rubenstein JL,Yang Z

更新日期：2016-08-02 00:00:00

abstract：:Ectopic expression of transcription factors (TFs) can reprogram cell state. However, because of the large combinatorial space of possible TF cocktails, it remains difficult to identify TFs that reprogram specific cell types. Here, we develop Reprogram-Seq to experimentally screen thousands of TF cocktails for reprogra...

journal_title：Cell reports

authors： Duan J,Li B,Bhakta M,Xie S,Zhou P,Munshi NV,Hon GC

更新日期：2019-06-18 00:00:00

abstract：:The fluorescence microscopy methods presently used to characterize protein motion in cells infer protein motion from indirect observables, rather than measuring protein motion directly. Operationalizing these methods requires expertise that can constitute a barrier to their broad utilization. Here, we have developed P...

journal_title：Cell reports

authors： Gura Sadovsky R,Brielle S,Kaganovich D,England JL

更新日期：2017-03-14 00:00:00

abstract：:Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated an...

journal_title：Cell reports

authors： Mateu-Regué À,Christiansen J,Bagger FO,Winther O,Hellriegel C,Nielsen FC

更新日期：2019-10-15 00:00:00

abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...

journal_title：Cell reports

authors： Fiorentino A,Christophorou A,Massa F,Garbay S,Chiral M,Ramsing M,Rasmussen M,Gubler MC,Bessieres B,Heidet L,Fischer E,Pontoglio M

更新日期：2020-10-27 00:00:00

abstract：:The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood. Here, we demonstrate that Kdm5a deficiency impairs activation of natural killer (NK) cells, with decreased IFN-γ production. Accordingly, Kdm5a...

journal_title：Cell reports

authors： Zhao D,Zhang Q,Liu Y,Li X,Zhao K,Ding Y,Li Z,Shen Q,Wang C,Li N,Cao X

更新日期：2016-04-12 00:00:00

abstract：:Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation. However, the role of other neurotransmitters in BAT homeostasis remains largely...

journal_title：Cell reports

authors： Ikegami R,Shimizu I,Sato T,Yoshida Y,Hayashi Y,Suda M,Katsuumi G,Li J,Wakasugi T,Minokoshi Y,Okamoto S,Hinoi E,Nielsen S,Jespersen NZ,Scheele C,Soga T,Minamino T

更新日期：2018-09-11 00:00:00

abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

journal_title：Cell reports

authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

更新日期：2018-04-10 00:00:00

abstract：:One of the most notable characteristics of synaptic transmission is the wide variation in synaptic strength in response to identical stimulation. In hippocampal neurons, approximately one-third of axonal mitochondria are highly motile, and some dynamically pass through presynaptic boutons. This raises a fundamental qu...

journal_title：Cell reports

authors： Sun T,Qiao H,Pan PY,Chen Y,Sheng ZH

更新日期：2013-08-15 00:00:00

abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...

journal_title：Cell reports

authors： Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz A

更新日期：2013-06-27 00:00:00

abstract：:Nuclear factor κB (NF-κB) RelA is the potent transcriptional activator of inflammatory response genes. We stringently defined a list of direct RelA target genes by integrating physical (chromatin immunoprecipitation sequencing [ChIP-seq]) and functional (RNA sequencing [RNA-seq] in knockouts) datasets. We then dissect...

journal_title：Cell reports

authors： Ngo KA,Kishimoto K,Davis-Turak J,Pimplaskar A,Cheng Z,Spreafico R,Chen EY,Tam A,Ghosh G,Mitchell S,Hoffmann A

更新日期：2020-02-25 00:00:00

abstract：:The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have ...

journal_title：Cell reports

authors： Olbrich T,Vega-Sendino M,Murga M,de Carcer G,Malumbres M,Ortega S,Ruiz S,Fernandez-Capetillo O

更新日期：2019-07-16 00:00:00

abstract：:Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase ...

journal_title：Cell reports

authors： Tzeng TC,Schattgen S,Monks B,Wang D,Cerny A,Latz E,Fitzgerald K,Golenbock DT

更新日期：2016-07-12 00:00:00

abstract：:Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects rem...

journal_title：Cell reports

authors： Alvarez-Saavedra M,De Repentigny Y,Yang D,O'Meara RW,Yan K,Hashem LE,Racacho L,Ioshikhes I,Bulman DE,Parks RJ,Kothary R,Picketts DJ

更新日期：2016-10-11 00:00:00

abstract：:Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expre...

journal_title：Cell reports

authors： Merienne N,Vachey G,de Longprez L,Meunier C,Zimmer V,Perriard G,Canales M,Mathias A,Herrgott L,Beltraminelli T,Maulet A,Dequesne T,Pythoud C,Rey M,Pellerin L,Brouillet E,Perrier AL,du Pasquier R,Déglon N

更新日期：2017-09-19 00:00:00

abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...

journal_title：Cell reports

authors： Guo W,Hu Z,Bao Y,Li Y,Li S,Zheng Q,Lyu D,Chen D,Yu T,Li Y,Zhu X,Ding J,Zhao Y,He X,Huang S

更新日期：2018-02-20 00:00:00

abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...

journal_title：Cell reports

authors： Wang X,Yu R,Wang J,Lin Z,Han X,Deng Z,Fan L,He H,Deng XW,Chen H

更新日期：2020-04-21 00:00:00

abstract：:The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in ...

journal_title：Cell reports

authors： Zhang J,Gao X,Schmit F,Adelmant G,Eck MJ,Marto JA,Zhao JJ,Roberts TM

更新日期：2017-07-18 00:00:00

abstract：:Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of fem...

journal_title：Cell reports

authors： Goodwill HL,Manzano-Nieves G,LaChance P,Teramoto S,Lin S,Lopez C,Stevenson RJ,Theyel BB,Moore CI,Connors BW,Bath KG

更新日期：2018-11-27 00:00:00

abstract：:DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed DNA methylation in skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of a subset of genes enriched in metabo...

journal_title：Cell reports

authors： Barres R,Kirchner H,Rasmussen M,Yan J,Kantor FR,Krook A,Näslund E,Zierath JR

更新日期：2013-04-25 00:00:00

abstract：:Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the response of tumor-specific...

journal_title：Cell reports

authors： Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R

更新日期：2019-12-03 00:00:00

abstract：:Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute carrier family (SLC) 7 member 5 (SLC7A5), and SLC43A1 constitute a fee...

journal_title：Cell reports

authors： Yue M,Jiang J,Gao P,Liu H,Qing G

更新日期：2017-12-26 00:00:00

abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...

journal_title：Cell reports

authors： Rekaik H,Blaudin de Thé FX,Fuchs J,Massiani-Beaudoin O,Prochiantz A,Joshi RL

更新日期：2015-10-13 00:00:00

abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

journal_title：Cell reports

authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

更新日期：2014-11-06 00:00:00

abstract：:The fossil record is widely informative about evolution, but fossils are not systematically used to study the evolution of stem-cell-driven renewal. Here, we examined evolution of the continuous growth (hypselodonty) of rodent molar teeth, which is fuelled by the presence of dental stem cells. We studied occurrences o...

journal_title：Cell reports

authors： Tapaltsyan V,Eronen JT,Lawing AM,Sharir A,Janis C,Jernvall J,Klein OD

更新日期：2015-05-05 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...

journal_title：Cell reports

authors： Hines MJ,Coffre M,Mudianto T,Panduro M,Wigton EJ,Tegla C,Osorio-Vasquez V,Kageyama R,Benhamou D,Perez O,Bajwa S,McManus MT,Ansel KM,Melamed D,Koralov SB

更新日期：2020-12-01 00:00:00

abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

journal_title：Cell reports

authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

更新日期：2020-06-30 00:00:00