Abstract:
:Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine, and delivered back to the photoreceptor for histamine regeneration. Here, we identify an organic cation transporter, CarT (carcinine transporter), that transports carcinine into photoreceptors during histamine recycling. CarT mediated in vitro uptake of carcinine. Deletion of the CarT gene caused an accumulation of carcinine in laminar glia accompanied by a reduction in histamine, resulting in abolished photoreceptor signal transmission and blindness in behavioral assays. These defects were rescued by expression of CarT cDNA in photoreceptors, and they were reproduced by photoreceptor-specific CarT knockdown. Our findings suggest a common role for the conserved family of CarT-like transporters in maintaining histamine homeostasis in both mammalian and fly brains.
journal_name
Cell Repjournal_title
Cell reportsauthors
Chaturvedi R,Luan Z,Guo P,Li HSdoi
10.1016/j.celrep.2016.02.009subject
Has Abstractpub_date
2016-03-08 00:00:00pages
2076-2083issue
9issn
2211-1247pii
S2211-1247(16)30091-2journal_volume
14pub_type
杂志文章相关文献
Cell Reports文献大全abstract::Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.02.011
更新日期:2019-03-05 00:00:00
abstract::Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1. We show here that, in both fission yeasts and humans, Mpn1 processes the spliceosomal U6 small nuclear RNA (snRNA) posttranscriptionally. In Mpn...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2012.08.031
更新日期:2012-10-25 00:00:00
abstract::Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been descr...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.02.043
更新日期:2016-03-22 00:00:00
abstract::Spatiotemporal protein reorganization at DNA damage sites induced by genotoxic chemotherapies is crucial for DNA damage response (DDR), which influences treatment response by directing cancer cell fate. This process is orchestrated by valosin-containing protein (VCP), an AAA+ ATPase that extracts polyubiquinated chrom...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107745
更新日期:2020-06-09 00:00:00
abstract::Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, and this may bias sub...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.01.075
更新日期:2018-03-06 00:00:00
abstract::RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations are known to originate in replication errors, difficulties of capturing the underlying dynamics have left the mechanochemical b...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.01.031
更新日期:2015-02-17 00:00:00
abstract::The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extend...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.060
更新日期:2018-01-09 00:00:00
abstract::In budding yeast, a mother cell can produce a finite number of daughter cells before it stops dividing and dies. Such entry into senescence is thought to result from a progressive decline in physiological function, including a loss of mitochondrial membrane potential (ΔΨ). Here, we developed a microfluidic device to m...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.11.013
更新日期:2013-12-26 00:00:00
abstract::The neurodevelopmental origin of hyperactivity disorder has been suggested to involve the dopaminergic system, but the underlying mechanisms are still unknown. Here, transcription factors Lmx1a and Lmx1b are shown to be essential for midbrain dopaminergic (mDA) neuron excitatory synaptic inputs and dendritic developme...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.01.084
更新日期:2020-02-18 00:00:00
abstract::Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.03.009
更新日期:2016-04-05 00:00:00
abstract::Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.03.066
更新日期:2018-04-10 00:00:00
abstract::Ring NTPases are a class of ubiquitous molecular motors involved in basic biological partitioning processes. dsDNA viruses encode ring ATPases that translocate their genomes to near-crystalline densities within pre-assembled viral capsids. Here, X-ray crystallography, cryoEM, and biochemical analyses of the dsDNA pack...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.01.058
更新日期:2016-03-01 00:00:00
abstract::At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.04.032
更新日期:2015-05-19 00:00:00
abstract::Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit pr...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.01.067
更新日期:2019-02-12 00:00:00
abstract::Chromatin interactions play important roles in transcription regulation. To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chromatin interactions in human cells. We found that 40% of the total gen...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2012.09.022
更新日期:2012-11-29 00:00:00
abstract::Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.03.123
更新日期:2018-05-08 00:00:00
abstract::Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intrigui...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.02.051
更新日期:2016-03-22 00:00:00
abstract::LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 precursors (pre-let-7) by promoting oligouridylation by terminal ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.02.044
更新日期:2017-03-14 00:00:00
abstract::Colorectal cancer (CRC) onset is profoundly affected by Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific colonic lysine homocysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase (MARS) expression and K-Hcy ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.09.022
更新日期:2018-10-09 00:00:00
abstract::BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached t...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.11.063
更新日期:2016-12-20 00:00:00
abstract::The ability to link events that are separated in time is important for extracting meaning from experiences and guiding behavior in the future. This ability likely requires the brain to continue representing events even after they have passed, a process that may involve the prefrontal cortex and takes the form of susta...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.05.021
更新日期:2016-06-14 00:00:00
abstract::Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA. Here, we show that naproxen is a potential broad, multi-mechanistic anti-influenza virus therapeutic, as it inhibits influenza B virus...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.04.053
更新日期:2019-05-07 00:00:00
abstract::Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.06.074
更新日期:2018-07-24 00:00:00
abstract::Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.01.052
更新日期:2019-02-05 00:00:00
abstract::Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition an...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.072
更新日期:2018-01-16 00:00:00
abstract::T follicular helper (Tfh) cells are crucial for the establishment of germinal centers (GCs) and potent antibody responses. Nevertheless, the T cell-intrinsic factors that are required for the maintenance of already-established Tfh cells and GCs remain largely unknown. Here, we use temporally guided gene ablation in CD...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108232
更新日期:2020-10-06 00:00:00
abstract::Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.01.081
更新日期:2018-02-27 00:00:00
abstract::Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.008
更新日期:2018-05-08 00:00:00
abstract::Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent kinase 1 (Cdk1) activates HR by phosphorylation of key recombination f...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.11.044
更新日期:2014-12-24 00:00:00
abstract::The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the ERAD-associated ubiquitin l...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107944
更新日期:2020-08-04 00:00:00