当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Abstract：

:Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by stimuli like vascular endothelial growth factor (VEGF) A. NFAT phosphorylation by dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) is thought to be an inactivating event. Contrary to expectations, we show that the DYRK family member DYRK1A positively regulates VEGF-dependent NFAT transcriptional responses in primary endothelial cells. DYRK1A silencing reduces intracellular Ca2+ influx in response to VEGF, which dampens NFAT activation. The effect is exerted at the level of VEGFR2 accumulation leading to impairment in PLCγ1 activation. Notably, Dyrk1a heterozygous mice show defects in developmental retinal vascularization. Our data establish a regulatory circuit, DYRK1A/ Ca2+/NFAT, to fine-tune endothelial cell proliferation and angiogenesis.

journal_name

Cell Rep

journal_title

Cell reports

authors

Rozen EJ,Roewenstrunk J,Barallobre MJ,Di Vona C,Jung C,Figueiredo AF,Luna J,Fillat C,Arbonés ML,Graupera M,Valverde MA,de la Luna S

doi

10.1016/j.celrep.2018.04.008

subject

Has Abstract

pub_date

2018-05-08 00:00:00

pages

1867-1878

issue

6

issn

2211-1247

pii

S2211-1247(18)30537-0

journal_volume

23

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.

    abstract：:HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we demonstrate that FEZ1 directly interacts with the HIV-1 capsid and specifically binds capsid protein (CA) hexamers. FEZ1 contains multip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.07.079

    authors： Huang PT,Summers BJ,Xu C,Perilla JR,Malikov V,Naghavi MH,Xiong Y

    更新日期：2019-08-27 00:00:00

  • The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2.

    abstract：:Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal GABA neurotransmission from excitatory to inhibitory, a developmental process known as the GABA switch. Using hippocampal neurons from Oxtr-null mice, we show that (1) Oxtr is necessary for the correct timing of the GABA switc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.03.013

    authors： Leonzino M,Busnelli M,Antonucci F,Verderio C,Mazzanti M,Chini B

    更新日期：2016-04-05 00:00:00

  • Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins.

    abstract：:As the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited. Here, we find that tankyrase inhibitors suppress YAP activity. This effect is medi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.014

    authors： Wang W,Li N,Li X,Tran MK,Han X,Chen J

    更新日期：2015-10-20 00:00:00

  • Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling.

    abstract：:Effective approaches to neuropsychiatric disorders require detailed understanding of the cellular composition and circuitry of the complex mammalian brain. Here, we present a paradigm for deconstructing the diversity of neurons defined by a specific neurotransmitter using a microfluidic dynamic array to simultaneously...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.008

    authors： Poulin JF,Zou J,Drouin-Ouellet J,Kim KY,Cicchetti F,Awatramani RB

    更新日期：2014-11-06 00:00:00

  • Computational Design of Epitope-Specific Functional Antibodies.

    abstract：:The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple structural models. Machine learning is used to analyze these models and pre...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.081

    authors： Nimrod G,Fischman S,Austin M,Herman A,Keyes F,Leiderman O,Hargreaves D,Strajbl M,Breed J,Klompus S,Minton K,Spooner J,Buchanan A,Vaughan TJ,Ofran Y

    更新日期：2018-11-20 00:00:00

  • Pitpnc1a Regulates Zebrafish Sleep and Wake Behavior through Modulation of Insulin-like Growth Factor Signaling.

    abstract：:The lipid transporters of the phosphatidylinositol transfer protein (PITP) family dictate phosphoinositide compartmentalization, and specific phosphoinositides play crucial roles in signaling cascades, membrane traffic, ion channel regulation, and actin dynamics. Although PITPs are enriched in the brain, their physiol...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.012

    authors： Ashlin TG,Blunsom NJ,Ghosh M,Cockcroft S,Rihel J

    更新日期：2018-08-07 00:00:00

  • Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

    abstract：:At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis. Therefore, the coupling of exo- and endocytosis is crucial. Despite...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.060

    authors： Orlando M,Schmitz D,Rosenmund C,Herman MA

    更新日期：2019-12-17 00:00:00

  • A Single Templating RNA in Yeast Telomerase.

    abstract：:The number of essential telomerase components in the active ribonucleoprotein (RNP) has important implications for its mechanism of action yet is by and large unknown. We report that two differentially tagged TLC1 RNAs endogenously expressed in a heterozygous diploid and simultaneously detected via multi-color fluores...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.045

    authors： Bajon E,Laterreur N,Wellinger RJ

    更新日期：2015-07-21 00:00:00

  • Circadian Clock Regulation of Developmental Time in the Kidney.

    abstract：:We report the emergence of an endogenous circadian clock that regulates organogenesis in mouse fetal kidney. We detect circadian rhythms both in vivo with transcriptional profiling and ex vivo by bioluminescence. High-resolution structural analysis of embryonic explants reveals that global or local clock disruption re...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107661

    authors： Dan H,Ruan T,Sampogna RV

    更新日期：2020-05-19 00:00:00

  • Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.

    abstract：:The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of Sox9. In regenerating kidneys, Sox9 expres...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.12.071

    authors： Kang HM,Huang S,Reidy K,Han SH,Chinga F,Susztak K

    更新日期：2016-02-02 00:00:00

  • miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.

    abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108436

    authors： Hines MJ,Coffre M,Mudianto T,Panduro M,Wigton EJ,Tegla C,Osorio-Vasquez V,Kageyama R,Benhamou D,Perez O,Bajwa S,McManus MT,Ansel KM,Melamed D,Koralov SB

    更新日期：2020-12-01 00:00:00

  • Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo.

    abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.115

    authors： Scholes C,Biette KM,Harden TT,DePace AH

    更新日期：2019-02-26 00:00:00

  • Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1.

    abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.063

    authors： Nersesyan Y,Demirkhanyan L,Cabezas-Bratesco D,Oakes V,Kusuda R,Dawson T,Sun X,Cao C,Cohen AM,Chelluboina B,Veeravalli KK,Zimmermann K,Domene C,Brauchi S,Zakharian E

    更新日期：2017-11-07 00:00:00

  • Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.

    abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.047

    authors： Rupaimoole R,Lee J,Haemmerle M,Ling H,Previs RA,Pradeep S,Wu SY,Ivan C,Ferracin M,Dennison JB,Millward NMZ,Nagaraja AS,Gharpure KM,McGuire M,Sam N,Armaiz-Pena GN,Sadaoui NC,Rodriguez-Aguayo C,Calin GA,Drapkin RI,K

    更新日期：2015-12-22 00:00:00

  • Fcμ receptor as a Costimulatory Molecule for T Cells.

    abstract：:Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells fro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.024

    authors： Meryk A,Pangrazzi L,Hagen M,Hatzmann F,Jenewein B,Jakic B,Hermann-Kleiter N,Baier G,Jylhävä J,Hurme M,Trieb K,Grubeck-Loebenstein B

    更新日期：2019-03-05 00:00:00

  • Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.

    abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2011.12.002

    authors： Hammachi F,Morrison GM,Sharov AA,Livigni A,Narayan S,Papapetrou EP,O'Malley J,Kaji K,Ko MS,Ptashne M,Brickman JM

    更新日期：2012-02-23 00:00:00

  • Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract.

    abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.106

    authors： Furter M,Sellin ME,Hansson GC,Hardt WD

    更新日期：2019-05-28 00:00:00

  • TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.

    abstract：:Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory disease. Once activated, the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS)-STING pathway induces both type I interferon ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.056

    authors： Balka KR,Louis C,Saunders TL,Smith AM,Calleja DJ,D'Silva DB,Moghaddas F,Tailler M,Lawlor KE,Zhan Y,Burns CJ,Wicks IP,Miner JJ,Kile BT,Masters SL,De Nardo D

    更新日期：2020-04-07 00:00:00

  • A comprehensive and high-resolution genome-wide response of p53 to stress.

    abstract：:Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChI...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.030

    authors： Chang GS,Chen XA,Park B,Rhee HS,Li P,Han KH,Mishra T,Chan-Salis KY,Li Y,Hardison RC,Wang Y,Pugh BF

    更新日期：2014-07-24 00:00:00

  • CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells.

    abstract：:CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited specificity for mature...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107651

    authors： Riggan L,Hildreth AD,Rolot M,Wong YY,Satyadi W,Sun R,Huerta C,O'Sullivan TE

    更新日期：2020-05-19 00:00:00

  • Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.

    abstract：:Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances stres...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.050

    authors： Nono M,Kishimoto S,Sato-Carlton A,Carlton PM,Nishida E,Uno M

    更新日期：2020-03-10 00:00:00

  • SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing.

    abstract：:Telomerase biogenesis is a complex process where several steps remain poorly understood. Single-strand-selective uracil-DNA glycosylase (SMUG1) associates with the DKC1-containing H/ACA ribonucleoprotein complex, which is essential for telomerase biogenesis. Herein, we show that SMUG1 interacts with the telomeric RNA ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.07.040

    authors： Kroustallaki P,Lirussi L,Carracedo S,You P,Esbensen QY,Götz A,Jobert L,Alsøe L,Sætrom P,Gagos S,Nilsen H

    更新日期：2019-08-13 00:00:00

  • Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.

    abstract：:Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.03.096

    authors： Graham LC,Naldrett MJ,Kohama SG,Smith C,Lamont DJ,McColl BW,Gillingwater TH,Skehel P,Urbanski HF,Wishart TM

    更新日期：2019-04-23 00:00:00

  • Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom.

    abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.03.030

    authors： Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

    更新日期：2015-04-21 00:00:00

  • PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum.

    abstract：:The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium g...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.081

    authors： Florentin A,Cobb DW,Fishburn JD,Cipriano MJ,Kim PS,Fierro MA,Striepen B,Muralidharan V

    更新日期：2017-11-14 00:00:00

  • Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes.

    abstract：:DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molec...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.12.022

    authors： Vlijm R,Lee M,Lipfert J,Lusser A,Dekker C,Dekker NH

    更新日期：2015-01-13 00:00:00

  • Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

    abstract：:While the I kappa kinase (IKK) scaffolding protein NF-κB essential modulator (NEMO) binds to polyubiquitin chains to transmit inflammatory signals, NEMO itself is also ubiquitinated in response to a variety of inflammatory agonists. Although there have been hints that polyubiquitination of NEMO is essential for avoidi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.036

    authors： Jun JC,Kertesy S,Jones MB,Marinis JM,Cobb BA,Tigno-Aranjuez JT,Abbott DW

    更新日期：2013-07-25 00:00:00

  • Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events.

    abstract：:The ability to link events that are separated in time is important for extracting meaning from experiences and guiding behavior in the future. This ability likely requires the brain to continue representing events even after they have passed, a process that may involve the prefrontal cortex and takes the form of susta...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.021

    authors： Volle J,Yu X,Sun H,Tanninen SE,Insel N,Takehara-Nishiuchi K

    更新日期：2016-06-14 00:00:00

  • Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.

    abstract：:Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currently being developed t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.11.073

    authors： Guo Y,MacIsaac KD,Chen Y,Miller RJ,Jain R,Joyce-Shaikh B,Ferguson H,Wang IM,Cristescu R,Mudgett J,Engstrom L,Piers KJ,Baltus GA,Barr K,Zhang H,Mehmet H,Hegde LG,Hu X,Carter LL,Aicher TD,Glick G,Zaller D,Hawwar

    更新日期：2016-12-20 00:00:00

  • Interferon-mediated innate immune responses against malaria parasite liver stages.

    abstract：:Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by thes...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.018

    authors： Miller JL,Sack BK,Baldwin M,Vaughan AM,Kappe SHI

    更新日期：2014-04-24 00:00:00