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Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export.

Abstract：

:Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA. Here, we show that naproxen is a potential broad, multi-mechanistic anti-influenza virus therapeutic, as it inhibits influenza B virus replication both in vivo and in vitro. The anti-influenza B virus activity of naproxen is more efficient than that of the commonly used neuraminidase inhibitor oseltamivir in mice. Furthermore, the NP of influenza B virus (BNP) has a higher binding affinity to naproxen than influenza A virus NP (ANP). Specifically, naproxen targets the NP at residues F209 (BNP) and Y148 (ANP). This interaction antagonizes the nuclear export of NP normally mediated by the host export protein CRM1. This study reveals a crucial mechanism of broad-spectrum anti-influenza virus activity of naproxen, suggesting that the existing drug naproxen may be used as an anti-influenza drug.

journal_name

Cell Rep

journal_title

Cell reports

authors

Zheng W,Fan W,Zhang S,Jiao P,Shang Y,Cui L,Mahesutihan M,Li J,Wang D,Gao GF,Sun L,Liu W

doi

10.1016/j.celrep.2019.04.053

subject

Has Abstract

pub_date

2019-05-07 00:00:00

pages

1875-1885.e5

issue

6

issn

2211-1247

pii

S2211-1247(19)30526-1

journal_volume

27

pub_type

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