当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification.

HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification.

Abstract：

:The recent HIV-1 vaccine failures highlight the need to better understand virus-host interactions. One key question is why CD8(+) T cell responses to two HIV-Gag regions are uniquely associated with delayed disease progression only in patients expressing a few rare HLA class I variants when these regions encode epitopes presented by ~30 more common HLA variants. By combining epitope processing and computational analyses of the two HIV subtypes responsible for ~60% of worldwide infections, we identified a hitherto unrecognized adaptation to the antigen-processing machinery through substitutions at subtype-specific motifs. Multiple HLA variants presenting epitopes situated next to a given subtype-specific motif drive selection at this subtype-specific position, and epitope abundances correlate inversely with the HLA frequency distribution in affected populations. This adaptation reflects the sum of intrapatient adaptations, is predictable, facilitates viral subtype diversification, and increases global HIV diversity. Because low epitope abundance is associated with infrequent and weak T cell responses, this most likely results in both population-level immune evasion and inadequate responses in most people vaccinated with natural HIV-1 sequence constructs. Our results suggest that artificial sequence modifications at subtype-specific positions in vitro could refocus and reverse the poor immunogenicity of HIV proteins.

journal_name

Cell Rep

journal_title

Cell reports

authors

Tenzer S,Crawford H,Pymm P,Gifford R,Sreenu VB,Weimershaus M,de Oliveira T,Burgevin A,Gerstoft J,Akkad N,Lunn D,Fugger L,Bell J,Schild H,van Endert P,Iversen AKN

doi

10.1016/j.celrep.2014.03.031

subject

Has Abstract

pub_date

2014-04-24 00:00:00

pages

448-463

issue

2

issn

2211-1247

pii

S2211-1247(14)00209-5

journal_volume

7

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • A Regulatory Program for Initiation of Wnt Signaling during Posterior Regeneration.

    abstract：:Whole-body regeneration relies on the re-establishment of body axes for patterning of new tissue. Wnt signaling is required to correctly regenerate tissues along the primary axis in many animals. However, the causal mechanisms that first launch Wnt signaling during regeneration are poorly characterized. We use the aco...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108098

    authors： Ramirez AN,Loubet-Senear K,Srivastava M

    更新日期：2020-09-01 00:00:00

  • A Targeted Multi-omic Analysis Approach Measures Protein Expression and Low-Abundance Transcripts on the Single-Cell Level.

    abstract：:High-throughput single-cell RNA sequencing (scRNA-seq) has become a frequently used tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and protein expression was developed, commonly known as cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Acquisition of prote...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.03.063

    authors： Mair F,Erickson JR,Voillet V,Simoni Y,Bi T,Tyznik AJ,Martin J,Gottardo R,Newell EW,Prlic M

    更新日期：2020-04-07 00:00:00

  • Specificity and function of archaeal DNA replication initiator proteins.

    abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.01.002

    authors： Samson RY,Xu Y,Gadelha C,Stone TA,Faqiri JN,Li D,Qin N,Pu F,Liang YX,She Q,Bell SD

    更新日期：2013-02-21 00:00:00

  • In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

    abstract：:Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.063

    authors： Carugo A,Genovese G,Seth S,Nezi L,Rose JL,Bossi D,Cicalese A,Shah PK,Viale A,Pettazzoni PF,Akdemir KC,Bristow CA,Robinson FS,Tepper J,Sanchez N,Gupta S,Estecio MR,Giuliani V,Dellino GI,Riva L,Yao W,Di Francesco

    更新日期：2016-06-28 00:00:00

  • LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation.

    abstract：:Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) as an essential re...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107600

    authors： Wang Y,Wang H,Guo J,Gao J,Wang M,Xia M,Wen Y,Su P,Yang M,Liu M,Shi L,Cheng T,Zhou W,Zhou J

    更新日期：2020-05-05 00:00:00

  • Temporal Control of Metabolic Amplitude by Nocturnin.

    abstract：:The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Noctur...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.01.011

    authors： Stubblefield JJ,Gao P,Kilaru G,Mukadam B,Terrien J,Green CB

    更新日期：2018-01-30 00:00:00

  • Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks.

    abstract：:Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential roles in genome stability through undefined tasks at damaged replication forks. Various subunits...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.123

    authors： Zapatka M,Pociño-Merino I,Heluani-Gahete H,Bermúdez-López M,Tarrés M,Ibars E,Solé-Soler R,Gutiérrez-Escribano P,Apostolova S,Casas C,Aragon L,Wellinger R,Colomina N,Torres-Rosell J

    更新日期：2019-12-03 00:00:00

  • Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.

    abstract：:Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.01.054

    authors： Bianchi FT,Tocco C,Pallavicini G,Liu Y,Vernì F,Merigliano C,Bonaccorsi S,El-Assawy N,Priano L,Gai M,Berto GE,Chiotto AM,Sgrò F,Caramello A,Tasca L,Ala U,Neri F,Oliviero S,Mauro A,Geley S,Gatti M,Di Cunto F

    更新日期：2017-02-14 00:00:00

  • IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation.

    abstract：:Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.077

    authors： He J,Yang Q,Xiao Q,Lei A,Li X,Zhou P,Liu T,Zhang L,Shi K,Yang Q,Dong J,Zhou J

    更新日期：2019-11-26 00:00:00

  • Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex.

    abstract：:The transcriptional response to infection with the bacterium Listeria monocytogenes (Lm) requires cooperative signals of the type I interferon (IFN-I)-stimulated JAK-STAT and proinflammatory NF-κB pathways. Using ChIP-seq analysis, we define genes induced in Lm-infected macrophages through synergistic transcriptional ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.021

    authors： Wienerroither S,Shukla P,Farlik M,Majoros A,Stych B,Vogl C,Cheon H,Stark GR,Strobl B,Müller M,Decker T

    更新日期：2015-07-14 00:00:00

  • GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.

    abstract：:The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107543

    authors： Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

    更新日期：2020-04-21 00:00:00

  • mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.

    abstract：:The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size. However, the function of mTORC1 on NSC self-renewal and the downstre...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.09.017

    authors： Hartman NW,Lin TV,Zhang L,Paquelet GE,Feliciano DM,Bordey A

    更新日期：2013-10-31 00:00:00

  • Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death.

    abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.020

    authors： Miura H,Kondo Y,Matsuda M,Aoki K

    更新日期：2018-09-04 00:00:00

  • Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

    abstract：:At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis. Therefore, the coupling of exo- and endocytosis is crucial. Despite...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.060

    authors： Orlando M,Schmitz D,Rosenmund C,Herman MA

    更新日期：2019-12-17 00:00:00

  • Sequence-dependent elongation dynamics on macrolide-bound ribosomes.

    abstract：:The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.034

    authors： Johansson M,Chen J,Tsai A,Kornberg G,Puglisi JD

    更新日期：2014-06-12 00:00:00

  • Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.

    abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.12.016

    authors： Xu D,Zhang F,Wang Y,Sun Y,Xu Z

    更新日期：2014-01-16 00:00:00

  • Antibiotics Disrupt Coordination between Transcriptional and Phenotypic Stress Responses in Pathogenic Bacteria.

    abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.062

    authors： Jensen PA,Zhu Z,van Opijnen T

    更新日期：2017-08-15 00:00:00

  • Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection.

    abstract：:Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-confirmed ZIKV infection at early-acute, late-acute, and convalescent tim...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107569

    authors： Michlmayr D,Kim EY,Rahman AH,Raghunathan R,Kim-Schulze S,Che Y,Kalayci S,Gümüş ZH,Kuan G,Balmaseda A,Kasarskis A,Wolinsky SM,Suaréz-Fariñas M,Harris E

    更新日期：2020-04-28 00:00:00

  • Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure.

    abstract：:Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor mechanisms limiting the oncogenic potential of these cells have been described. However, the universal applicability of these tumor-suppressive barriers remains contro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.006

    authors： Gerlach SU,Eichenlaub T,Herranz H

    更新日期：2018-05-01 00:00:00

  • Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.

    abstract：:Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the psq gene, which has diverse roles in development and tumorigenesis, encodes dist...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.07.096

    authors： Gutierrez-Perez I,Rowley MJ,Lyu X,Valadez-Graham V,Vallejo DM,Ballesta-Illan E,Lopez-Atalaya JP,Kremsky I,Caparros E,Corces VG,Dominguez M

    更新日期：2019-09-03 00:00:00

  • Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells.

    abstract：:Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT, but the relation among the markers is not known. Here, we used t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.086

    authors： Gulyaeva O,Nguyen H,Sambeat A,Heydari K,Sul HS

    更新日期：2018-10-23 00:00:00

  • Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.

    abstract：:DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed DNA methylation in skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of a subset of genes enriched in metabo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.03.018

    authors： Barres R,Kirchner H,Rasmussen M,Yan J,Kantor FR,Krook A,Näslund E,Zierath JR

    更新日期：2013-04-25 00:00:00

  • Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons.

    abstract：:Cognitive capacities decline with age, an event accompanied by the altered transcription of synaptic plasticity genes. Here, we show that the transcriptional induction of Bdnf by a mnemonic stimulus is impaired in aged hippocampal neurons. Mechanistically, this defect is due to reduced NMDA receptor (NMDAR)-mediated a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.028

    authors： Palomer E,Martín-Segura A,Baliyan S,Ahmed T,Balschun D,Venero C,Martin MG,Dotti CG

    更新日期：2016-09-13 00:00:00

  • Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation.

    abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.123

    authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

    更新日期：2018-05-08 00:00:00

  • KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.

    abstract：:The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not well defined. Here, we report that KDM4C transcriptionally activates amino acid biosynthesis and transport, leading to a significant increase in...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.12.053

    authors： Zhao E,Ding J,Xia Y,Liu M,Ye B,Choi JH,Yan C,Dong Z,Huang S,Zha Y,Yang L,Cui H,Ding HF

    更新日期：2016-01-26 00:00:00

  • Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.

    abstract：:SARM1 function and nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) loss both promote axon degeneration, but their relative relationship in the process is unknown. Here, we show that NMNAT2 loss and resultant changes to NMNAT metabolites occur in injured SARM1-deficient axons despite their delayed degenerati...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.02.060

    authors： Gilley J,Orsomando G,Nascimento-Ferreira I,Coleman MP

    更新日期：2015-03-31 00:00:00

  • Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products.

    abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.042

    authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

    更新日期：2019-11-19 00:00:00

  • Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

    abstract：:The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a cri...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.127

    authors： Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

    更新日期：2018-05-01 00:00:00

  • Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection.

    abstract：:Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.005

    authors： Coultrap SJ,Freund RK,O'Leary H,Sanderson JL,Roche KW,Dell'Acqua ML,Bayer KU

    更新日期：2014-02-13 00:00:00

  • Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene.

    abstract：:Many animals fight for dominance between conspecifics. Because winners could obtain more resources than losers, fighting outcomes are important for the animal's survival, especially in a situation with insufficient resources, such as hunger. However, it remains unclear whether and how hunger affects fighting outcomes....

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107790

    authors： Nakajo H,Chou MY,Kinoshita M,Appelbaum L,Shimazaki H,Tsuboi T,Okamoto H

    更新日期：2020-06-23 00:00:00