A Regulatory Program for Initiation of Wnt Signaling during Posterior Regeneration.

abstract：:Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specific...

journal_title：Cell reports

authors： Romania P,Cifaldi L,Pignoloni B,Starc N,D'Alicandro V,Melaiu O,Li Pira G,Giorda E,Carrozzo R,Bergvall M,Bergström T,Alfredsson L,Olsson T,Kockum I,Seppälä I,Lehtimäki T,Hurme MA,Hengel H,Santoni A,Cerboni C,Locate

更新日期：2017-07-25 00:00:00

abstract：:Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that ...

journal_title：Cell reports

authors： Xing F,Luan Y,Cai J,Wu S,Mai J,Gu J,Zhang H,Li K,Lin Y,Xiao X,Liang J,Li Y,Chen W,Tan Y,Sheng L,Lu B,Lu W,Gao M,Qiu P,Su X,Yin W,Hu J,Chen Z,Sai K,Wang J,Chen F,Chen Y,Zhu S,Liu D,Cheng S,Xie Z

更新日期：2017-01-10 00:00:00

abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...

journal_title：Cell reports

authors： Ruivo MTG,Vera IM,Sales-Dias J,Meireles P,Gural N,Bhatia SN,Mota MM,Mancio-Silva L

更新日期：2016-09-06 00:00:00

abstract：:Sensory processing can be tuned by a neuron's integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the pos...

journal_title：Cell reports

authors： Yu WQ,El-Danaf RN,Okawa H,Pacholec JM,Matti U,Schwarz K,Odermatt B,Dunn FA,Lagnado L,Schmitz F,Huberman AD,Wong ROL

更新日期：2018-11-20 00:00:00

abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...

journal_title：Cell reports

authors： Delpretti S,Montavon T,Leleu M,Joye E,Tzika A,Milinkovitch M,Duboule D

更新日期：2013-10-17 00:00:00

abstract：:The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have ...

journal_title：Cell reports

authors： Olbrich T,Vega-Sendino M,Murga M,de Carcer G,Malumbres M,Ortega S,Ruiz S,Fernandez-Capetillo O

更新日期：2019-07-16 00:00:00

abstract：:Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

journal_title：Cell reports

authors： Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

更新日期：2014-04-10 00:00:00

abstract：:Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step in rescuing stalled ribosomes. Here we identify NONU-1 as a factor required for translation surveillance pathways including no-go and...

journal_title：Cell reports

authors： Glover ML,Burroughs AM,Monem PC,Egelhofer TA,Pule MN,Aravind L,Arribere JA

更新日期：2020-03-31 00:00:00

abstract：:Intracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on the formation and fusion of vesicular carriers. Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER), whereas COPI vesicles facilitate traffic from the Golg...

journal_title：Cell reports

authors： Adolf F,Rhiel M,Hessling B,Gao Q,Hellwig A,Béthune J,Wieland FT

更新日期：2019-01-02 00:00:00

abstract：:Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methylation study following nerve injury. We show that genes involved in t...

journal_title：Cell reports

authors： Arthur-Farraj PJ,Morgan CC,Adamowicz M,Gomez-Sanchez JA,Fazal SV,Beucher A,Razzaghi B,Mirsky R,Jessen KR,Aitman TJ

更新日期：2017-09-12 00:00:00

abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...

journal_title：Cell reports

authors： Gao X,Zhang Z,Mashimo T,Shen B,Nyagilo J,Wang H,Wang Y,Liu Z,Mulgaonkar A,Hu XL,Piccirillo SGM,Eskiocak U,Davé DP,Qin S,Yang Y,Sun X,Fu YX,Zong H,Sun W,Bachoo RM,Ge WP

更新日期：2020-02-25 00:00:00

abstract：:FBXL2 targets IP3R3 for ubiquitin-mediated degradation to limit Ca2+ flux to mitochondria and, consequently, apoptosis. Efficient replication of hepatitis C virus (HCV) requires geranylgeranylation of FBXL2. Here, we show that the viral protein NS5A forms a trimeric complex with IP3R3 and FBXL2, unmasking IP3R3's degr...

journal_title：Cell reports

authors： Kuchay S,Saeed M,Giorgi C,Li J,Hoffmann HH,Pinton P,Rice CM,Pagano M

更新日期：2018-10-23 00:00:00

abstract：:53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage de...

journal_title：Cell reports

authors： Baldock RA,Day M,Wilkinson OJ,Cloney R,Jeggo PA,Oliver AW,Watts FZ,Pearl LH

更新日期：2015-12-15 00:00:00

abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

journal_title：Cell reports

authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

更新日期：2014-11-06 00:00:00

abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...

journal_title：Cell reports

authors： Guo W,Hu Z,Bao Y,Li Y,Li S,Zheng Q,Lyu D,Chen D,Yu T,Li Y,Zhu X,Ding J,Zhao Y,He X,Huang S

更新日期：2018-02-20 00:00:00

abstract：:Loss of NF-κB signaling causes immunodeficiency, whereas inhibition of NF-κB can be efficacious in treating chronic inflammatory disease. Inflammatory NF-κB signaling must therefore be tightly regulated, and although many mechanisms to downregulate NF-κB have been elucidated, there have only been limited studies demon...

journal_title：Cell reports

authors： Perez JM,Chirieleison SM,Abbott DW

更新日期：2015-07-28 00:00:00

abstract：:Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However, lowering translational efficiency extends rather than shortens the l...

journal_title：Cell reports

authors： Dhondt I,Petyuk VA,Cai H,Vandemeulebroucke L,Vierstraete A,Smith RD,Depuydt G,Braeckman BP

更新日期：2016-09-13 00:00:00

abstract：:Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...

journal_title：Cell reports

authors： He J,Yang Q,Xiao Q,Lei A,Li X,Zhou P,Liu T,Zhang L,Shi K,Yang Q,Dong J,Zhou J

更新日期：2019-11-26 00:00:00

abstract：:Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic ...

journal_title：Cell reports

authors： Fujita Y,Khateb A,Li Y,Tinoco R,Zhang T,Bar-Yoseph H,Tam MA,Chowers Y,Sabo E,Gerassy-Vainberg S,Starosvetsky E,James B,Brown K,Shen-Orr SS,Bradley LM,Tessier PA,Ronai ZA

更新日期：2018-09-18 00:00:00

abstract：:Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene. We show that, although LRP1 transcript expression is upregulated in response to both sub-lethal and le...

journal_title：Cell reports

authors： Leslie PL,Franklin DA,Liu Y,Zhang Y

更新日期：2018-08-07 00:00:00

abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...

journal_title：Cell reports

authors： Xiao T,Wongtrakoongate P,Trainor C,Felsenfeld G

更新日期：2015-09-08 00:00:00

abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...

journal_title：Cell reports

authors： Kronforst MR,Hansen ME,Crawford NG,Gallant JR,Zhang W,Kulathinal RJ,Kapan DD,Mullen SP

更新日期：2013-11-14 00:00:00

abstract：:Megakaryocytes (MKs) come from a complex process of hematopoietic progenitor maturation within the bone marrow that gives rise to de novo circulating platelets. Bone marrow microenvironment contains a large number of adipocytes with a still ill-defined role. This study aims to analyze the influence of adipocytes and i...

journal_title：Cell reports

authors： Valet C,Batut A,Vauclard A,Dortignac A,Bellio M,Payrastre B,Valet P,Severin S

更新日期：2020-07-07 00:00:00

abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

journal_title：Cell reports

authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

更新日期：2017-09-19 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacteri...

journal_title：Cell reports

authors： Wang F,Kaplan JL,Gold BD,Bhasin MK,Ward NL,Kellermayer R,Kirschner BS,Heyman MB,Dowd SE,Cox SB,Dogan H,Steven B,Ferry GD,Cohen SA,Baldassano RN,Moran CJ,Garnett EA,Drake L,Otu HH,Mirny LA,Libermann TA,Winter HS

更新日期：2016-02-02 00:00:00

abstract：:Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely tuned to match changing energy requirements. To discover new pathways regulating glucose levels in vivo, we performed a larg...

journal_title：Cell reports

authors： Nath AK,Ryu JH,Jin YN,Roberts LD,Dejam A,Gerszten RE,Peterson RT

更新日期：2015-02-10 00:00:00

abstract：:Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by thes...

journal_title：Cell reports

authors： Miller JL,Sack BK,Baldwin M,Vaughan AM,Kappe SHI

更新日期：2014-04-24 00:00:00

abstract：:Genetically encoded effectors are important tools for probing cellular function in living animals, but improved methods for directing their expression to specific cell types are required. Here, we introduce a simple, versatile method for achieving cell-type-specific expression of transgenes that leverages the untapped...

journal_title：Cell reports

authors： Diao F,Ironfield H,Luan H,Diao F,Shropshire WC,Ewer J,Marr E,Potter CJ,Landgraf M,White BH

更新日期：2015-03-03 00:00:00

abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

journal_title：Cell reports

authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

更新日期：2014-05-22 00:00:00