Abstract：
:We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, including genome-wide association study (GWAS) hits. Immune gene expression correlated tightly with plaques whereas synaptic genes correlated negatively with neurofibrillary tangles. Network analysis of immune gene modules revealed six hub genes in hippocampus of amyloid mice, four in common with cortex. The hippocampal network in TAU mice was similar except that Trem2 had hub status only in amyloid mice. The cortical network of TAU mice was entirely different with more hub genes and few in common with the other networks, suggesting reasons for specificity of cortical dysfunction in FTDP17. This Resource opens up many areas for investigation. All data are available and searchable at http://www.mouseac.org.
journal_name
Cell Repjournal_title
Cell reportsauthors
Matarin M,Salih DA,Yasvoina M,Cummings DM,Guelfi S,Liu W,Nahaboo Solim MA,Moens TG,Paublete RM,Ali SS,Perona M,Desai R,Smith KJ,Latcham J,Fulleylove M,Richardson JC,Hardy J,Edwards FAdoi
10.1016/j.celrep.2014.12.041subject
Has Abstractpub_date
2015-02-03 00:00:00pages
633-44issue
4issn
2211-1247pii
S2211-1247(14)01094-8journal_volume
10pub_type
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