Abstract：
:X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and requires RIP3 but is independent of cIAP1/cIAP2. The observed cell death also requires TNF and RIP3 but proceeds independently of caspase-1/caspase-11 or caspase-8 function. Loss of XIAP results in aberrantly elevated ubiquitylation of RIP1 outside of TNFR complex I. Virally infected Xiap(-/-) mice present with symptoms reminiscent of XLP-2. Our data show that XIAP controls RIP3-dependent cell death and IL-1β secretion in response to TNF, which might contribute to hyperinflammation in patients with XLP-2.
journal_name
Cell Repjournal_title
Cell reportsauthors
Yabal M,Müller N,Adler H,Knies N,Groß CJ,Damgaard RB,Kanegane H,Ringelhan M,Kaufmann T,Heikenwälder M,Strasser A,Groß O,Ruland J,Peschel C,Gyrd-Hansen M,Jost PJdoi
10.1016/j.celrep.2014.05.008subject
Has Abstractpub_date
2014-06-26 00:00:00pages
1796-808issue
6issn
2211-1247pii
S2211-1247(14)00383-0journal_volume
7pub_type
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