Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound.

abstract：:Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, and dengue virus....

journal_title：Cell reports

authors： Perreira JM,Aker AM,Savidis G,Chin CR,McDougall WM,Portmann JM,Meraner P,Smith MC,Rahman M,Baker RE,Gauthier A,Franti M,Brass AL

更新日期：2015-08-04 00:00:00

abstract：:The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bo...

journal_title：Cell reports

authors： Wang CQ,Krishnan V,Tay LS,Chin DW,Koh CP,Chooi JY,Nah GS,Du L,Jacob B,Yamashita N,Lai SK,Tan TZ,Mori S,Tanuichi I,Tergaonkar V,Ito Y,Osato M

更新日期：2014-08-07 00:00:00

abstract：:While meta-analysis has demonstrated increased statistical power and more robust estimations in studies, the application of this commonly accepted methodology to cytometry data has been challenging. Different cytometry studies often involve diverse sets of markers. Moreover, the detected values of the same marker are ...

journal_title：Cell reports

authors： Hu Z,Jujjavarapu C,Hughey JJ,Andorf S,Lee HC,Gherardini PF,Spitzer MH,Thomas CG,Campbell J,Dunn P,Wiser J,Kidd BA,Dudley JT,Nolan GP,Bhattacharya S,Butte AJ

更新日期：2018-07-31 00:00:00

abstract：:Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the correlation between mRNA and protein abundance during development is...

journal_title：Cell reports

authors： Grün D,Kirchner M,Thierfelder N,Stoeckius M,Selbach M,Rajewsky N

更新日期：2014-02-13 00:00:00

abstract：:Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature to undergo glucose-stimulated insulin secretion, but molecular regulation of thi...

journal_title：Cell reports

authors： Velazco-Cruz L,Goedegebuure MM,Maxwell KG,Augsornworawat P,Hogrebe NJ,Millman JR

更新日期：2020-05-26 00:00:00

abstract：:Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we used high-resolution mass spectrometry and label-free protein quantification to measure proteomic differences between the seven largest circulating human CD8+ T...

journal_title：Cell reports

authors： van Aalderen MC,van den Biggelaar M,Remmerswaal EBM,van Alphen FPJ,Meijer AB,Ten Berge IJM,van Lier RAW

更新日期：2017-05-02 00:00:00

abstract：:Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we determine two crystal structures of the α2A adrenergic receptor (α2AAR) in complex with a partia...

journal_title：Cell reports

authors： Qu L,Zhou Q,Xu Y,Guo Y,Chen X,Yao D,Han GW,Liu ZJ,Stevens RC,Zhong G,Wu D,Zhao S

更新日期：2019-12-03 00:00:00

abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

journal_title：Cell reports

authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

更新日期：2012-11-29 00:00:00

abstract：:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia b...

journal_title：Cell reports

authors： Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kuru

更新日期：2017-01-17 00:00:00

abstract：:Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and are thus essential for glutamatergic neurotransmission. However, VGLUTs were originally discovered as members of a transporter subfamily specific for inorganic phosphate (Pi). It is still unclear how VGLUTs accommodate glutamate transp...

journal_title：Cell reports

authors： Preobraschenski J,Cheret C,Ganzella M,Zander JF,Richter K,Schenck S,Jahn R,Ahnert-Hilger G

更新日期：2018-04-10 00:00:00

abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

journal_title：Cell reports

authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

更新日期：2018-08-28 00:00:00

abstract：:The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized natu...

journal_title：Cell reports

authors： Invergo BM,Brochet M,Yu L,Choudhary J,Beltrao P,Billker O

更新日期：2017-11-14 00:00:00

abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...

journal_title：Cell reports

authors： Kronforst MR,Hansen ME,Crawford NG,Gallant JR,Zhang W,Kulathinal RJ,Kapan DD,Mullen SP

更新日期：2013-11-14 00:00:00

abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...

journal_title：Cell reports

authors： Wang Y,Ku CJ,Zhang ER,Artyukhin AB,Weiner OD,Wu LF,Altschuler SJ

更新日期：2013-05-30 00:00:00

abstract：:Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections. In this work, we explore the in vivo molecular dynamics of Mtb infection by performing dual RNA-seq on Mycobacterium tuberculosis-infected, ontogenetically d...

journal_title：Cell reports

authors： Pisu D,Huang L,Grenier JK,Russell DG

更新日期：2020-01-14 00:00:00

abstract：:Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNAi phenotypes in Caenorhabditis elegans provides an excellent model to study this phenomenon, and although studies have...

journal_title：Cell reports

authors： Woodhouse RM,Buchmann G,Hoe M,Harney DJ,Low JKK,Larance M,Boag PR,Ashe A

更新日期：2018-11-20 00:00:00

abstract：:Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape from immune surveilla...

journal_title：Cell reports

authors： Marro BS,Zak J,Zavareh RB,Teijaro JR,Lairson LL,Oldstone MBA

更新日期：2019-12-03 00:00:00

abstract：:Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. Here, we employ time-resolved two-photon excitation fluorescence imaging in acu...

journal_title：Cell reports

authors： King CM,Bohmbach K,Minge D,Delekate A,Zheng K,Reynolds J,Rakers C,Zeug A,Petzold GC,Rusakov DA,Henneberger C

更新日期：2020-03-10 00:00:00

abstract：:Diet-induced obesity (DIO) predisposes individuals to insulin resistance, and adipose tissue has a major role in the disease. Insulin resistance can be induced in cultured adipocytes by a variety of treatments, but what aspects of the in vivo responses are captured by these models remains unknown. We use global RNA se...

journal_title：Cell reports

authors： Lo KA,Labadorf A,Kennedy NJ,Han MS,Yap YS,Matthews B,Xin X,Sun L,Davis RJ,Lodish HF,Fraenkel E

更新日期：2013-10-17 00:00:00

abstract：:Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknow...

journal_title：Cell reports

authors： Adomati T,Cham LB,Hamdan TA,Bhat H,Duhan V,Li F,Ali M,Lang E,Huang A,Naser E,Khairnar V,Friedrich SK,Lang J,Friebus-Kardash J,Bergerhausen M,Schiller M,Machlah YM,Lang F,Häussinger D,Ferencik S,Hardt C,Lang PA,

更新日期：2020-03-17 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-...

journal_title：Cell reports

authors： Song L,He Y,Ou J,Zhao Y,Li R,Cheng J,Lin CH,Ho MS

更新日期：2017-01-31 00:00:00

abstract：:Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform...

journal_title：Cell reports

authors： O'Leary VB,Ovsepian SV,Carrascosa LG,Buske FA,Radulovic V,Niyazi M,Moertl S,Trau M,Atkinson MJ,Anastasov N

更新日期：2015-04-21 00:00:00

abstract：:Cell-cycle arrest in quiescence and senescence is largely orchestrated by the retinoblastoma (Rb) tumor-suppressor pathway, but the mechanisms underlying the quiescence-senescence switch remain unclear. Here, we show that the crosstalk between the Rb-AKT-signaling pathways forms this switch by controlling the overlapp...

journal_title：Cell reports

authors： Imai Y,Takahashi A,Hanyu A,Hori S,Sato S,Naka K,Hirao A,Ohtani N,Hara E

更新日期：2014-04-10 00:00:00

abstract：:Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate this pathway have not been performed. Using a ubiquitin C-terminal electrophile, we profil...

journal_title：Cell reports

authors： Jahan AS,Biquand E,Muñoz-Moreno R,Le Quang A,Mok CK,Wong HH,Teo QW,Valkenburg SA,Chin AWH,Man Poon LL,Te Velthuis A,García-Sastre A,Demeret C,Sanyal S

更新日期：2020-02-04 00:00:00

abstract：:Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data. Here, we describe a method for isolating large numbers of pure NBs and differentiating neurons that retain both cell-cycle and lineage cha...

journal_title：Cell reports

authors： Berger C,Harzer H,Burkard TR,Steinmann J,van der Horst S,Laurenson AS,Novatchkova M,Reichert H,Knoblich JA

更新日期：2012-08-30 00:00:00

abstract：:Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication orig...

journal_title：Cell reports

authors： Amin A,Wu R,Cheung MH,Scott JF,Wang Z,Zhou Z,Liu C,Zhu G,Wong CK,Yu Z,Liang C

更新日期：2020-03-10 00:00:00

abstract：:The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacteri...

journal_title：Cell reports

authors： Wang F,Kaplan JL,Gold BD,Bhasin MK,Ward NL,Kellermayer R,Kirschner BS,Heyman MB,Dowd SE,Cox SB,Dogan H,Steven B,Ferry GD,Cohen SA,Baldassano RN,Moran CJ,Garnett EA,Drake L,Otu HH,Mirny LA,Libermann TA,Winter HS

更新日期：2016-02-02 00:00:00

abstract：:CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA regulation. However, the relationship between target RNA binding and HEPN (higher eukaryotes and prokaryotes nucleotide binding) domain nuclease activation is poorl...

journal_title：Cell reports

authors： Tambe A,East-Seletsky A,Knott GJ,Doudna JA,O'Connell MR

更新日期：2018-07-24 00:00:00

abstract：:Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secr...

journal_title：Cell reports

authors： Nyitrai H,Wang SSH,Kaeser PS

更新日期：2020-06-09 00:00:00