Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota.

Abstract:

:The relationship between the host and its microbiota is challenging to understand because both microbial communities and their environments are highly variable. We have developed a set of techniques based on population dynamics and information theory to address this challenge. These methods identify additional bacterial taxa associated with pediatric Crohn disease and can detect significant changes in microbial communities with fewer samples than previous statistical approaches required. We have also substantially improved the accuracy of the diagnosis based on the microbiota from stool samples, and we found that the ecological niche of a microbe predicts its role in Crohn disease. Bacteria typically residing in the lumen of healthy individuals decrease in disease, whereas bacteria typically residing on the mucosa of healthy individuals increase in disease. Our results also show that the associations with Crohn disease are evolutionarily conserved and provide a mutual information-based method to depict dysbiosis.

journal_name

Cell Rep

journal_title

Cell reports

authors

Wang F,Kaplan JL,Gold BD,Bhasin MK,Ward NL,Kellermayer R,Kirschner BS,Heyman MB,Dowd SE,Cox SB,Dogan H,Steven B,Ferry GD,Cohen SA,Baldassano RN,Moran CJ,Garnett EA,Drake L,Otu HH,Mirny LA,Libermann TA,Winter HS

doi

10.1016/j.celrep.2015.12.088

subject

Has Abstract

pub_date

2016-02-02 00:00:00

pages

945-955

issue

4

issn

2211-1247

pii

S2211-1247(15)01544-2

journal_volume

14

pub_type

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