Abstract：
:Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform for transcriptional repression. In situ hybridization discloses that PARTICLE and MAT2A associate together following irradiation. Bromouridine tracing and presence in exosomes indicate intercellular transport, and this is supported by ex vivo data from radiotherapy-treated patients. Surface plasmon resonance indicates that PARTICLE forms a DNA-lncRNA triplex upstream of a MAT2A promoter CpG island. We show that PARTICLE represses MAT2A via methylation and demonstrate that the radiation-induced PARTICLE interacts with the transcription-repressive complex proteins G9a and SUZ12 (subunit of PRC2). The interplay of PARTICLE with MAT2A implicates this lncRNA in intercellular communication and as a recruitment platform for gene-silencing machineries through triplex formation in response to irradiation.
journal_name
Cell Repjournal_title
Cell reportsauthors
O'Leary VB,Ovsepian SV,Carrascosa LG,Buske FA,Radulovic V,Niyazi M,Moertl S,Trau M,Atkinson MJ,Anastasov Ndoi
10.1016/j.celrep.2015.03.043subject
Has Abstractpub_date
2015-04-21 00:00:00pages
474-85issue
3issn
2211-1247pii
S2211-1247(15)00322-8journal_volume
11pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of host glycolysis in Mtb-infected macrophages, which is dependent on sustained u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.015
更新日期：2020-01-07 00:00:00
abstract：:Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.080
更新日期：2018-03-20 00:00:00
abstract：:Dicistrovirus intergenic region internal ribosomal entry sites (IGR IRESs) do not require initiator tRNA, an AUG codon, or initiation factors and jumpstart translation from the middle of the elongation cycle via formation of IRES/80S complexes resembling the pre-translocation state. eEF2 then translocates the [codon-a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108476
更新日期：2020-12-08 00:00:00
abstract：:The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.12.006
更新日期：2017-01-03 00:00:00
abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.018
更新日期：2018-03-27 00:00:00
abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.085
更新日期：2018-05-22 00:00:00
abstract：:Megakaryocytes (MKs) come from a complex process of hematopoietic progenitor maturation within the bone marrow that gives rise to de novo circulating platelets. Bone marrow microenvironment contains a large number of adipocytes with a still ill-defined role. This study aims to analyze the influence of adipocytes and i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107875
更新日期：2020-07-07 00:00:00
abstract：:Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to pertur...
journal_title：Cell reports
pub_type： 杂志文章,评审
doi：10.1016/j.celrep.2020.108128
更新日期：2020-09-08 00:00:00
abstract：:Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and isocitrate dehydrogenase 1 (IDH1) mutations are tumorigenic, in part, because...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.053
更新日期：2017-04-11 00:00:00
abstract：:Cancer cell-derived secretomes have been documented to play critical roles in cancer progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved in various steps of tumor progression, which can offer strategies to fight cancer. Herein, we identify lung cancer progression-associate...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.037
更新日期：2020-02-11 00:00:00
abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.002
更新日期：2018-02-20 00:00:00
abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.039
更新日期：2020-01-14 00:00:00
abstract：:Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.042
更新日期：2019-06-11 00:00:00
abstract：:The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. Here, we show that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration but, surprisingly, have preserved mitochondrial co...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.04.023
更新日期：2013-05-30 00:00:00
abstract：:The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.053
更新日期：2017-08-15 00:00:00
abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.097
更新日期：2018-11-27 00:00:00
abstract：:Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothel...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.002
更新日期：2015-12-15 00:00:00
abstract：:Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear extinction defects. Postsynaptic NMDAR-dependent long-term depression (LTD) is sp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.089
更新日期：2018-06-26 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.01.005
更新日期：2017-01-31 00:00:00
abstract：:Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition, Smo gain-of-function mutations have limited their clinical implement...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.001
更新日期：2015-04-07 00:00:00
abstract：:During termination of translation, the nascent peptide is first released from the ribosome, which must be subsequently disassembled into subunits in a process known as ribosome recycling. In bacteria, termination and recycling are mediated by the translation factors RF, RRF, EF-G, and IF3, but their precise roles have...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.06.028
更新日期：2017-07-05 00:00:00
abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.076
更新日期：2015-10-13 00:00:00
abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.02.051
更新日期：2019-03-12 00:00:00
abstract：:Intracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on the formation and fusion of vesicular carriers. Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER), whereas COPI vesicles facilitate traffic from the Golg...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.041
更新日期：2019-01-02 00:00:00
abstract：:Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which are globally amplified, transcriptiona...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107884
更新日期：2020-07-14 00:00:00
abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.09.054
更新日期：2018-10-16 00:00:00
abstract：:Mammalian neocortex size primarily reflects the number and mode of divisions of neural stem and progenitor cells. Cortical stem cells (apical progenitors) switching from symmetric divisions, which expand their population, to asymmetric divisions, which generate downstream neuronal progenitors (basal progenitors), star...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.03.033
更新日期：2014-04-24 00:00:00
abstract：:Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) as an essential re...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107600
更新日期：2020-05-05 00:00:00
abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108405
更新日期：2020-11-17 00:00:00
abstract：:CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited specificity for mature...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107651
更新日期：2020-05-19 00:00:00
