CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.

abstract：:The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Throu...

journal_title：Cell reports

authors： Abrial M,Paffett-Lugassy N,Jeffrey S,Jordan D,O'Loughlin E,Frederick CJ 3rd,Burns CG,Burns CE

更新日期：2017-07-25 00:00:00

abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

journal_title：Cell reports

authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

更新日期：2019-06-04 00:00:00

abstract：:At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis. Therefore, the coupling of exo- and endocytosis is crucial. Despite...

journal_title：Cell reports

authors： Orlando M,Schmitz D,Rosenmund C,Herman MA

更新日期：2019-12-17 00:00:00

abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

journal_title：Cell reports

authors： Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

更新日期：2016-03-29 00:00:00

abstract：:Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn mo...

journal_title：Cell reports

authors： Senft AD,Costello I,King HW,Mould AW,Bikoff EK,Robertson EJ

更新日期：2018-08-21 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-...

journal_title：Cell reports

authors： Song L,He Y,Ou J,Zhao Y,Li R,Cheng J,Lin CH,Ho MS

更新日期：2017-01-31 00:00:00

abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

journal_title：Cell reports

authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

更新日期：2014-11-20 00:00:00

abstract：:The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a cri...

journal_title：Cell reports

authors： Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

更新日期：2018-05-01 00:00:00

abstract：:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs i...

journal_title：Cell reports

authors： Schuettengruber B,Oded Elkayam N,Sexton T,Entrevan M,Stern S,Thomas A,Yaffe E,Parrinello H,Tanay A,Cavalli G

更新日期：2014-10-09 00:00:00

abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...

journal_title：Cell reports

authors： Dweck HKM,Ebrahim SAM,Retzke T,Grabe V,Weißflog J,Svatoš A,Hansson BS,Knaden M

更新日期：2018-05-22 00:00:00

abstract：:Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barri...

journal_title：Cell reports

authors： Barrero MJ,Sese B,Kuebler B,Bilic J,Boue S,Martí M,Izpisua Belmonte JC

更新日期：2013-04-25 00:00:00

abstract：:BAK activation represents a key step during apoptosis, but how it converts into a mitochondria-permeabilizing pore remains unclear. By further delineating the structural rearrangements involved, we reveal that BAK activation progresses through a series of independent steps: BH3-domain exposure, N-terminal change, olig...

journal_title：Cell reports

authors： Weber K,Harper N,Schwabe J,Cohen GM

更新日期：2013-10-31 00:00:00

abstract：:A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8+ TCR repertoires for two dominant viral epitopes: pp65495-503 (NLV) of cytomegalovirus and M158-66 (GIL...

journal_title：Cell reports

authors： Chen G,Yang X,Ko A,Sun X,Gao M,Zhang Y,Shi A,Mariuzza RA,Weng NP

更新日期：2017-04-18 00:00:00

abstract：:Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to regulate neurogenesis and synaptic maturation at perinatal and postnatal stages. However, microglia invade the brain during mid-embryoge...

journal_title：Cell reports

authors： Squarzoni P,Oller G,Hoeffel G,Pont-Lezica L,Rostaing P,Low D,Bessis A,Ginhoux F,Garel S

更新日期：2014-09-11 00:00:00

abstract：:Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. However, the role of NBEA...

journal_title：Cell reports

authors： Gromova KV,Muhia M,Rothammer N,Gee CE,Thies E,Schaefer I,Kress S,Kilimann MW,Shevchuk O,Oertner TG,Kneussel M

更新日期：2018-05-29 00:00:00

abstract：:The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4...

journal_title：Cell reports

authors： Clottu AS,Mathias A,Sailer AW,Schluep M,Seebach JD,Du Pasquier R,Pot C

更新日期：2017-01-03 00:00:00

abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...

journal_title：Cell reports

authors： Nishiguchi MA,Spencer CA,Leung DH,Leung TH

更新日期：2018-09-25 00:00:00

abstract：:Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, and dengue virus....

journal_title：Cell reports

authors： Perreira JM,Aker AM,Savidis G,Chin CR,McDougall WM,Portmann JM,Meraner P,Smith MC,Rahman M,Baker RE,Gauthier A,Franti M,Brass AL

更新日期：2015-08-04 00:00:00

abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in nutrient homeostasis. GIP receptor (GIPR) is constitutively internalized and returned to the plasma membrane, atypical behavior for a G-protein-coupled receptor (GPCR). GIP promotes GIPR downregulation from the plasma membrane by inh...

journal_title：Cell reports

authors： Abdullah N,Beg M,Soares D,Dittman JS,McGraw TE

更新日期：2016-12-13 00:00:00

abstract：:Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...

journal_title：Cell reports

authors： Onikubo T,Nicklay JJ,Xing L,Warren C,Anson B,Wang WL,Burgos ES,Ruff SE,Shabanowitz J,Cheng RH,Hunt DF,Shechter D

更新日期：2015-03-17 00:00:00

abstract：:Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad functional diversity is unknown. Here, we show that inflammation and immune pathway genes are differentially regulated in an isoform-dependent manner, confirming t...

journal_title：Cell reports

authors： Ko HL,Zhuo Z,Ren EC

更新日期：2019-03-05 00:00:00

abstract：:The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compound...

journal_title：Cell reports

authors： Garcia H,Miecznikowski JC,Safina A,Commane M,Ruusulehto A,Kilpinen S,Leach RW,Attwood K,Li Y,Degan S,Omilian AR,Guryanova O,Papantonopoulou O,Wang J,Buck M,Liu S,Morrison C,Gurova KV

更新日期：2013-07-11 00:00:00

abstract：:Cognitive capacities decline with age, an event accompanied by the altered transcription of synaptic plasticity genes. Here, we show that the transcriptional induction of Bdnf by a mnemonic stimulus is impaired in aged hippocampal neurons. Mechanistically, this defect is due to reduced NMDA receptor (NMDAR)-mediated a...

journal_title：Cell reports

authors： Palomer E,Martín-Segura A,Baliyan S,Ahmed T,Balschun D,Venero C,Martin MG,Dotti CG

更新日期：2016-09-13 00:00:00

abstract：:The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify feature...

journal_title：Cell reports

authors： Coloma J,Jain R,Rajashankar KR,García-Sastre A,Aggarwal AK

更新日期：2016-09-20 00:00:00

abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...

journal_title：Cell reports

authors： Malkani S,Chin CR,Cekanaviciute E,Mortreux M,Okinula H,Tarbier M,Schreurs AS,Shirazi-Fard Y,Tahimic CGT,Rodriguez DN,Sexton BS,Butler D,Verma A,Bezdan D,Durmaz C,MacKay M,Melnick A,Meydan C,Li S,Garrett-Bakelman F,

更新日期：2020-12-08 00:00:00

abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

journal_title：Cell reports

authors： Miura H,Kondo Y,Matsuda M,Aoki K

更新日期：2018-09-04 00:00:00

abstract：:Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, the molecular events that predispose WAT to hypertrophy are poorly defined. Here, we demonstrate that adipocyte hypertrophy is triggered by loss of the corepressor GPS2 durin...

journal_title：Cell reports

authors： Drareni K,Ballaire R,Barilla S,Mathew MJ,Toubal A,Fan R,Liang N,Chollet C,Huang Z,Kondili M,Foufelle F,Soprani A,Roussel R,Gautier JF,Alzaid F,Treuter E,Venteclef N

更新日期：2018-09-11 00:00:00

abstract：:Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression o...

journal_title：Cell reports

authors： Chowdhury D,Alrefai H,Landero Figueroa JA,Candor K,Porollo A,Fecher R,Divanovic S,Deepe GS Jr,Subramanian Vignesh K

更新日期：2019-06-25 00:00:00

abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...

journal_title：Cell reports

authors： Samson RY,Xu Y,Gadelha C,Stone TA,Faqiri JN,Li D,Qin N,Pu F,Liang YX,She Q,Bell SD

更新日期：2013-02-21 00:00:00