Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.

abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...

journal_title：Cell reports

authors： Joost S,Jacob T,Sun X,Annusver K,La Manno G,Sur I,Kasper M

更新日期：2018-10-16 00:00:00

abstract：:Mutations in BLM helicase predispose Bloom syndrome (BS) patients to a wide spectrum of cancers. We demonstrate that MIB1-ubiquitylated BLM in G1 phase functions as an adaptor protein by enhancing the binding of transcription factor c-Jun and its E3 ligase, Fbw7α. BLM enhances the K48/K63-linked ubiquitylation on c-Ju...

journal_title：Cell reports

authors： Priyadarshini R,Hussain M,Attri P,Kaur E,Tripathi V,Priya S,Dhapola P,Saha D,Madhavan V,Chowdhury S,Sengupta S

更新日期：2018-07-24 00:00:00

abstract：:Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1. We show here that, in both fission yeasts and humans, Mpn1 processes the spliceosomal U6 small nuclear RNA (snRNA) posttranscriptionally. In Mpn...

journal_title：Cell reports

authors： Shchepachev V,Wischnewski H,Missiaglia E,Soneson C,Azzalin CM

更新日期：2012-10-25 00:00:00

abstract：:Colorectal cancer (CRC) onset is profoundly affected by Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific colonic lysine homocysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase (MARS) expression and K-Hcy ...

journal_title：Cell reports

authors： Wang D,Zhao R,Qu YY,Mei XY,Zhang X,Zhou Q,Li Y,Yang SB,Zuo ZG,Chen YM,Lin Y,Xu W,Chen C,Zhao SM,Zhao JY

更新日期：2018-10-09 00:00:00

abstract：:Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT, but the relation among the markers is not known. Here, we used t...

journal_title：Cell reports

authors： Gulyaeva O,Nguyen H,Sambeat A,Heydari K,Sul HS

更新日期：2018-10-23 00:00:00

abstract：:Leptin has beneficial effects on glucose metabolism via actions in the hypothalamus, but the roles of specific subgroups of neurons responsible for these antidiabetic effects remain unresolved. We generated diabetic Lep(ob/ob) or Lepr(db/db) mice lacking or re-expressing leptin receptors (LepRb) in subgroups of neuron...

journal_title：Cell reports

authors： Gonçalves GH,Li W,Garcia AV,Figueiredo MS,Bjørbæk C

更新日期：2014-05-22 00:00:00

abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...

journal_title：Cell reports

authors： Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

更新日期：2020-10-27 00:00:00

abstract：:Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals a...

journal_title：Cell reports

authors： Bianchi FT,Tocco C,Pallavicini G,Liu Y,Vernì F,Merigliano C,Bonaccorsi S,El-Assawy N,Priano L,Gai M,Berto GE,Chiotto AM,Sgrò F,Caramello A,Tasca L,Ala U,Neri F,Oliviero S,Mauro A,Geley S,Gatti M,Di Cunto F

更新日期：2017-02-14 00:00:00

abstract：:The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5' ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited ...

journal_title：Cell reports

authors： Mukherjee C,Patil DP,Kennedy BA,Bakthavachalu B,Bundschuh R,Schoenberg DR

更新日期：2012-09-27 00:00:00

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

journal_title：Cell reports

authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

更新日期：2017-09-19 00:00:00

abstract：:Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone i...

journal_title：Cell reports

authors： Nemes-Baran AD,White DR,DeSilva TM

更新日期：2020-08-18 00:00:00

abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...

journal_title：Cell reports

authors： Li J,Paulo JA,Nusinow DP,Huttlin EL,Gygi SP

更新日期：2019-11-12 00:00:00

abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...

journal_title：Cell reports

authors： Nishiguchi MA,Spencer CA,Leung DH,Leung TH

更新日期：2018-09-25 00:00:00

abstract：:Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic switch that promotes tumorigenesis. Here, we demonstrate that PGC...

journal_title：Cell reports

authors： LaGory EL,Wu C,Taniguchi CM,Ding CC,Chi JT,von Eyben R,Scott DA,Richardson AD,Giaccia AJ

更新日期：2015-07-07 00:00:00

abstract：:Most current tumor immunotherapy strategies leverage cytotoxic CD8+ T cells. Despite evidence for clinical potential of CD4+ tumor-infiltrating lymphocytes (TILs), their functional diversity limits our ability to harness their activity. Here, we use single-cell mRNA sequencing to analyze the response of tumor-specific...

journal_title：Cell reports

authors： Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R

更新日期：2019-12-03 00:00:00

abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

journal_title：Cell reports

authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

更新日期：2013-01-31 00:00:00

abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

journal_title：Cell reports

authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

更新日期：2020-05-12 00:00:00

abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

journal_title：Cell reports

authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

更新日期：2018-03-06 00:00:00

abstract：:Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation ...

journal_title：Cell reports

authors： Yoshinaga M,Nakatsuka Y,Vandenbon A,Ori D,Uehata T,Tsujimura T,Suzuki Y,Mino T,Takeuchi O

更新日期：2017-05-23 00:00:00

abstract：:Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...

journal_title：Cell reports

authors： Polaski JT,Holmstrom ED,Nesbitt DJ,Batey RT

更新日期：2016-05-03 00:00:00

abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

journal_title：Cell reports

authors： Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

更新日期：2020-01-14 00:00:00

abstract：:Cancer cell-derived secretomes have been documented to play critical roles in cancer progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved in various steps of tumor progression, which can offer strategies to fight cancer. Herein, we identify lung cancer progression-associate...

journal_title：Cell reports

authors： Wang C,Zhang S,Liu J,Tian Y,Ma B,Xu S,Fu Y,Luo Y

更新日期：2020-02-11 00:00:00

abstract：:Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory ...

journal_title：Cell reports

authors： Alagapan S,Riddle J,Huang WA,Hadar E,Shin HW,Fröhlich F

更新日期：2019-11-26 00:00:00

abstract：:One critical event in reprogramming to pluripotency is erasure of the somatic transcriptional program of starting cells. Here, we present the proof of principle of a strategy for reprogramming to pluripotency facilitated by small molecules that interfere with the somatic transcriptional memory. We show that mild chemi...

journal_title：Cell reports

authors： Shao Z,Yao C,Khodadadi-Jamayran A,Xu W,Townes TM,Crowley MR,Hu K

更新日期：2016-09-20 00:00:00

abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

journal_title：Cell reports

authors： Miura H,Kondo Y,Matsuda M,Aoki K

更新日期：2018-09-04 00:00:00

abstract：:The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compound...

journal_title：Cell reports

authors： Garcia H,Miecznikowski JC,Safina A,Commane M,Ruusulehto A,Kilpinen S,Leach RW,Attwood K,Li Y,Degan S,Omilian AR,Guryanova O,Papantonopoulou O,Wang J,Buck M,Liu S,Morrison C,Gurova KV

更新日期：2013-07-11 00:00:00

abstract：:We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes observed in p73 knockout mice including hydrocephalus; hippocampal dys...

journal_title：Cell reports

authors： Marshall CB,Mays DJ,Beeler JS,Rosenbluth JM,Boyd KL,Santos Guasch GL,Shaver TM,Tang LJ,Liu Q,Shyr Y,Venters BJ,Magnuson MA,Pietenpol JA

更新日期：2016-03-15 00:00:00

abstract：:The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing the same exon 45-47 in-frame deletio...

journal_title：Cell reports

authors： Fiorillo AA,Heier CR,Novak JS,Tully CB,Brown KJ,Uaesoontrachoon K,Vila MC,Ngheim PP,Bello L,Kornegay JN,Angelini C,Partridge TA,Nagaraju K,Hoffman EP

更新日期：2015-09-08 00:00:00

abstract：:ADP-ribosylation (ADPr) is a reversible posttranslational modification involved in a range of cellular processes. Here, we report system-wide identification of serine ADPr in human cells upon oxidative stress. High-resolution mass spectrometry and unrestricted data processing confirm that serine residues are the major...

journal_title：Cell reports

authors： Larsen SC,Hendriks IA,Lyon D,Jensen LJ,Nielsen ML

更新日期：2018-08-28 00:00:00