Abstract:
:The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4+ T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4+ T cells and is enhanced under natalizumab treatment. These data suggest a significant role for EBI2 in human CD4+ T cell migration, notably in patients with MS. Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.
journal_name
Cell Repjournal_title
Cell reportsauthors
Clottu AS,Mathias A,Sailer AW,Schluep M,Seebach JD,Du Pasquier R,Pot Cdoi
10.1016/j.celrep.2016.12.006subject
Has Abstractpub_date
2017-01-03 00:00:00pages
213-224issue
1issn
2211-1247pii
S2211-1247(16)31679-5journal_volume
18pub_type
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