Abstract：
:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs is not well understood. Here, we use comparative epigenomics and transgenic assays to show that Drosophila domain organization and PRE specification are evolutionarily conserved despite significant cis-element divergence within Polycomb domains, whereas cis-element evolution is strongly correlated with transcription factor binding divergence outside of Polycomb domains. Cooperative interactions of PcG complexes and their recruiting factor PHO stabilize PHO recruitment to low-specificity sequences. Consistently, PHO recruitment to sites within Polycomb domains is stabilized by PRC1. These data suggest that cooperative rather than hierarchical interactions among low-affinity sequences, DNA-binding factors, and the Polycomb machinery are giving rise to specific and strongly conserved 3D structures in Drosophila.
journal_name
Cell Repjournal_title
Cell reportsauthors
Schuettengruber B,Oded Elkayam N,Sexton T,Entrevan M,Stern S,Thomas A,Yaffe E,Parrinello H,Tanay A,Cavalli Gdoi
10.1016/j.celrep.2014.08.072subject
Has Abstractpub_date
2014-10-09 00:00:00pages
219-233issue
1issn
2211-1247pii
S2211-1247(14)00764-5journal_volume
9pub_type
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