Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.

abstract：:Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper control of this local translation. Here, we find that the deaden...

journal_title：Cell reports

authors： McFleder RL,Mansur F,Richter JD

更新日期：2017-07-18 00:00:00

abstract：:Colorectal cancer (CRC) onset is profoundly affected by Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific colonic lysine homocysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase (MARS) expression and K-Hcy ...

journal_title：Cell reports

authors： Wang D,Zhao R,Qu YY,Mei XY,Zhang X,Zhou Q,Li Y,Yang SB,Zuo ZG,Chen YM,Lin Y,Xu W,Chen C,Zhao SM,Zhao JY

更新日期：2018-10-09 00:00:00

abstract：:Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N6-methyladenosine (m6A) mRNA methylation impacts circadian regulation of lipid metabolism is unclear. Here, we show m6A mRNA methylation oscillations in murine liv...

journal_title：Cell reports

authors： Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V

更新日期：2018-11-13 00:00:00

abstract：:Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the correlation between mRNA and protein abundance during development is...

journal_title：Cell reports

authors： Grün D,Kirchner M,Thierfelder N,Stoeckius M,Selbach M,Rajewsky N

更新日期：2014-02-13 00:00:00

abstract：:AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impr...

journal_title：Cell reports

authors： Ulgherait M,Rana A,Rera M,Graniel J,Walker DW

更新日期：2014-09-25 00:00:00

abstract：:The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produce IL-10. IL-18 act...

journal_title：Cell reports

authors： Clark SE,Schmidt RL,McDermott DS,Lenz LL

更新日期：2018-05-29 00:00:00

abstract：:The recent success of derivation of mammalian haploid embryonic stem cells (haESCs) has provided a powerful tool for large-scale functional analysis of the mammalian genome. However, haESCs rapidly become diploidized after differentiation, posing challenges for genetic analysis. Here, we show that the spontaneous dipl...

journal_title：Cell reports

authors： He ZQ,Xia BL,Wang YK,Li J,Feng GH,Zhang LL,Li YH,Wan HF,Li TD,Xu K,Yuan XW,Li YF,Zhang XX,Zhang Y,Wang L,Li W,Zhou Q

更新日期：2017-08-29 00:00:00

abstract：:α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

journal_title：Cell reports

authors： Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

更新日期：2017-12-05 00:00:00

abstract：:Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation. However, the role of other neurotransmitters in BAT homeostasis remains largely...

journal_title：Cell reports

authors： Ikegami R,Shimizu I,Sato T,Yoshida Y,Hayashi Y,Suda M,Katsuumi G,Li J,Wakasugi T,Minokoshi Y,Okamoto S,Hinoi E,Nielsen S,Jespersen NZ,Scheele C,Soga T,Minamino T

更新日期：2018-09-11 00:00:00

abstract：:Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these latter cellular responses require Rac-mediated remodeling of the actin cytoskeleton, we hypothesized that molecules involved in Rac activation ...

journal_title：Cell reports

authors： Tajiri H,Uruno T,Shirai T,Takaya D,Matsunaga S,Setoyama D,Watanabe M,Kukimoto-Niino M,Oisaki K,Ushijima M,Sanematsu F,Honma T,Terada T,Oki E,Shirasawa S,Maehara Y,Kang D,Côté JF,Yokoyama S,Kanai M,Fukui Y

更新日期：2017-05-02 00:00:00

abstract：:The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is overexpressed in gliomas where it increases the efficiency of the DNA damage response (DDR) pathway b...

journal_title：Cell reports

authors： Ohba S,Johannessen TA,Chatla K,Yang X,Pieper RO,Mukherjee J

更新日期：2020-04-14 00:00:00

abstract：:MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects. Here, we describe an approach to characterizing miRNA-regulatory networks b...

journal_title：Cell reports

authors： Gosline SJ,Gurtan AM,JnBaptiste CK,Bosson A,Milani P,Dalin S,Matthews BJ,Yap YS,Sharp PA,Fraenkel E

更新日期：2016-01-12 00:00:00

abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...

journal_title：Cell reports

authors： Scholes C,Biette KM,Harden TT,DePace AH

更新日期：2019-02-26 00:00:00

abstract：:The NMDA receptor (NMDAR) antagonist ketamine elicits a long-lasting antidepressant response in patients with treatment-resistant depression. Understanding how antagonism of NMDARs alters synapse and circuit function is pivotal to developing circuit-based therapies for depression. Using virally induced gene deletion, ...

journal_title：Cell reports

authors： Miller OH,Bruns A,Ben Ammar I,Mueggler T,Hall BJ

更新日期：2017-08-22 00:00:00

abstract：:Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α...

journal_title：Cell reports

authors： Traub S,Meier DT,Schulze F,Dror E,Nordmann TM,Goetz N,Koch N,Dalmas E,Stawiski M,Makshana V,Thorel F,Herrera PL,Böni-Schnetzler M,Donath MY

更新日期：2017-03-28 00:00:00

abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...

journal_title：Cell reports

authors： Dweck HKM,Ebrahim SAM,Retzke T,Grabe V,Weißflog J,Svatoš A,Hansson BS,Knaden M

更新日期：2018-05-22 00:00:00

abstract：:Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape from immune surveilla...

journal_title：Cell reports

authors： Marro BS,Zak J,Zavareh RB,Teijaro JR,Lairson LL,Oldstone MBA

更新日期：2019-12-03 00:00:00

abstract：:There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical in...

journal_title：Cell reports

authors： Robbins N,Spitzer M,Yu T,Cerone RP,Averette AK,Bahn YS,Heitman J,Sheppard DC,Tyers M,Wright GD

更新日期：2015-11-17 00:00:00

abstract：:Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with various parameters of glucose homeostasis and susceptibility to type 2 diabete...

journal_title：Cell reports

authors： Wigger L,Cruciani-Guglielmacci C,Nicolas A,Denom J,Fernandez N,Fumeron F,Marques-Vidal P,Ktorza A,Kramer W,Schulte A,Le Stunff H,Liechti R,Xenarios I,Vollenweider P,Waeber G,Uphues I,Roussel R,Magnan C,Ibberson M,Th

更新日期：2017-02-28 00:00:00

abstract：:During an infection the antigen-nonspecific memory CD8 T cell compartment is not simply an inert pool of cells, but becomes activated and cytotoxic. It is unknown how these cells contribute to the clearance of an infection. We measured the strength of T cell receptor (TCR) signals that bystander-activated, cytotoxic C...

journal_title：Cell reports

authors： Chu T,Tyznik AJ,Roepke S,Berkley AM,Woodward-Davis A,Pattacini L,Bevan MJ,Zehn D,Prlic M

更新日期：2013-03-28 00:00:00

abstract：:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia b...

journal_title：Cell reports

authors： Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kuru

更新日期：2017-01-17 00:00:00

abstract：:Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining gen...

journal_title：Cell reports

authors： Wang X,Tucciarone J,Jiang S,Yin F,Wang BS,Wang D,Jia Y,Jia X,Li Y,Yang T,Xu Z,Akram MA,Wang Y,Zeng S,Ascoli GA,Mitra P,Gong H,Luo Q,Huang ZJ

更新日期：2019-03-12 00:00:00

abstract：:Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genom...

journal_title：Cell reports

authors： Izzo A,Kamieniarz-Gdula K,Ramírez F,Noureen N,Kind J,Manke T,van Steensel B,Schneider R

更新日期：2013-06-27 00:00:00

abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...

journal_title：Cell reports

authors： Camacho J,Truong L,Kurt Z,Chen YW,Morselli M,Gutierrez G,Pellegrini M,Yang X,Allard P

更新日期：2018-05-22 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To investigate the role of autophagy in Aβ pathology in vivo, we cr...

journal_title：Cell reports

authors： Nilsson P,Loganathan K,Sekiguchi M,Matsuba Y,Hui K,Tsubuki S,Tanaka M,Iwata N,Saito T,Saido TC

更新日期：2013-10-17 00:00:00

abstract：:Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here, we show that altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact on ne...

journal_title：Cell reports

authors： Jin J,Kim SN,Liu X,Zhang H,Zhang C,Seo JS,Kim Y,Sun T

更新日期：2016-08-09 00:00:00

abstract：:Telomerase biogenesis is a complex process where several steps remain poorly understood. Single-strand-selective uracil-DNA glycosylase (SMUG1) associates with the DKC1-containing H/ACA ribonucleoprotein complex, which is essential for telomerase biogenesis. Herein, we show that SMUG1 interacts with the telomeric RNA ...

journal_title：Cell reports

authors： Kroustallaki P,Lirussi L,Carracedo S,You P,Esbensen QY,Götz A,Jobert L,Alsøe L,Sætrom P,Gagos S,Nilsen H

更新日期：2019-08-13 00:00:00

abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...

journal_title：Cell reports

authors： Garay PM,Chen A,Tsukahara T,Rodríguez Díaz JC,Kohen R,Althaus JC,Wallner MA,Giger RJ,Jones KS,Sutton MA,Iwase S

更新日期：2020-08-11 00:00:00

abstract：:The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophila, when administer...

journal_title：Cell reports

authors： Castillo-Quan JI,Li L,Kinghorn KJ,Ivanov DK,Tain LS,Slack C,Kerr F,Nespital T,Thornton J,Hardy J,Bjedov I,Partridge L

更新日期：2016-04-19 00:00:00

abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

journal_title：Cell reports

authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

更新日期：2018-03-06 00:00:00