Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner.

abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

journal_title：Cell reports

authors： Furter M,Sellin ME,Hansson GC,Hardt WD

更新日期：2019-05-28 00:00:00

abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

journal_title：Cell reports

authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

更新日期：2018-11-27 00:00:00

abstract：:Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Several modulators of ligand-gated ion channels have recently been identified, s...

journal_title：Cell reports

authors： Salm EJ,Dunn PJ,Shan L,Yamasaki M,Malewicz NM,Miyazaki T,Park J,Sumioka A,Hamer RRL,He WW,Morimoto-Tomita M,LaMotte RH,Tomita S

更新日期：2020-06-02 00:00:00

abstract：:Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...

journal_title：Cell reports

authors： Schlesinger S,Lee AH,Wang GZ,Green L,Goff SP

更新日期：2013-07-11 00:00:00

abstract：:RNA polymerase II transcripts receive a protective 5',5'-triphosphate-linked 7-methylguanosine (m7G) cap, and its removal by decapping enzymes like DCP2 is critical for initiation of RNA decay. Alternative RNA caps can be acquired when transcription initiation uses metabolites like nicotinamide adenine dinucleotide (N...

journal_title：Cell reports

authors： Wu H,Li L,Chen KM,Homolka D,Gos P,Fleury-Olela F,McCarthy AA,Pillai RS

更新日期：2019-12-24 00:00:00

abstract：:The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we demonstrate that SVBP acts as a bona...

journal_title：Cell reports

authors： van der Laan S,Lévêque MF,Marcellin G,Vezenkov L,Lannay Y,Dubra G,Bompard G,Ovejero S,Urbach S,Burgess A,Amblard M,Sterkers Y,Bastien P,Rogowski K

更新日期：2019-12-17 00:00:00

abstract：:The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the pr...

journal_title：Cell reports

authors： Joe Y,Chen Y,Park J,Kim HJ,Rah SY,Ryu J,Cho GJ,Choi HS,Ryter SW,Park JW,Kim UH,Chung HT

更新日期：2020-01-28 00:00:00

abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

journal_title：Cell reports

authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

更新日期：2020-08-11 00:00:00

abstract：:Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property chan...

journal_title：Cell reports

authors： Grimsholm O,Piano Mortari E,Davydov AN,Shugay M,Obraztsova AS,Bocci C,Marasco E,Marcellini V,Aranburu A,Farroni C,Silvestris DA,Cristofoletti C,Giorda E,Scarsella M,Cascioli S,Barresi S,Lougaris V,Plebani A,Cancrini C

更新日期：2020-03-03 00:00:00

abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

journal_title：Cell reports

authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

更新日期：2015-07-28 00:00:00

abstract：:Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors ...

journal_title：Cell reports

authors： Grassi L,Pourfarzad F,Ullrich S,Merkel A,Were F,Carrillo-de-Santa-Pau E,Yi G,Hiemstra IH,Tool ATJ,Mul E,Perner J,Janssen-Megens E,Berentsen K,Kerstens H,Habibi E,Gut M,Yaspo ML,Linser M,Lowy E,Datta A,Clarke L,F

更新日期：2018-09-04 00:00:00

abstract：:Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular compo...

journal_title：Cell reports

authors： Bressan M,Henley T,Louie JD,Liu G,Christodoulou D,Bai X,Taylor J,Seidman CE,Seidman JG,Mikawa T

更新日期：2018-05-22 00:00:00

abstract：:Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABAA subunit-containing GABAA receptors (δGABAARs) that respond to ambient GABA levels and context-dependent neuromodulators like steroids. We find that GC-specific deletion of δGABAA (cerebellar [cb] δ knockout [KO]) decreases tonic inhibition...

journal_title：Cell reports

authors： Rudolph S,Guo C,Pashkovski SL,Osorno T,Gillis WF,Krauss JM,Nyitrai H,Flaquer I,El-Rifai M,Datta SR,Regehr WG

更新日期：2020-11-03 00:00:00

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cell...

journal_title：Cell reports

authors： Ellebrecht CT,Mukherjee EM,Zheng Q,Choi EJ,Reddy SG,Mao X,Payne AS

更新日期：2018-08-28 00:00:00

abstract：:Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC ...

journal_title：Cell reports

authors： Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA

更新日期：2020-10-13 00:00:00

abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...

journal_title：Cell reports

authors： Laflamme G,Sim S,Leary A,Pascariu M,Vogel J,D'Amours D

更新日期：2019-03-12 00:00:00

abstract：:Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying mechanisms. To address these issues, we perform a comprehensive RNA-seq analysis of aging, ischemic stroke, and their interaction in 3- and 18-month-old mice. We assess differ...

journal_title：Cell reports

authors： Androvic P,Kirdajova D,Tureckova J,Zucha D,Rohlova E,Abaffy P,Kriska J,Valny M,Anderova M,Kubista M,Valihrach L

更新日期：2020-06-16 00:00:00

abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...

journal_title：Cell reports

authors： Agarwal A,Zhang M,Trembak-Duff I,Unterbarnscheidt T,Radyushkin K,Dibaj P,Martins de Souza D,Boretius S,Brzózka MM,Steffens H,Berning S,Teng Z,Gummert MN,Tantra M,Guest PC,Willig KI,Frahm J,Hell SW,Bahn S,Rossner MJ

更新日期：2014-08-21 00:00:00

abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

journal_title：Cell reports

authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

更新日期：2018-05-08 00:00:00

abstract：:Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA d...

journal_title：Cell reports

authors： Chen CF,Ruiz-Vega R,Vasudeva P,Espitia F,Krasieva TB,de Feraudy S,Tromberg BJ,Huang S,Garner CP,Wu J,Hoon DS,Ganesan AK

更新日期：2017-03-07 00:00:00

abstract：:After implantation, pluripotent epiblasts are converted to embryonic ectoderm through cell-cell interactions that significantly change the transcriptional and epigenetic networks. An entrée to understanding this vital developmental transition is the t(w5) mutation of the mouse t complex. This mutation produces highly ...

journal_title：Cell reports

authors： Sugimoto M,Kondo M,Hirose M,Suzuki M,Mekada K,Abe T,Kiyonari H,Ogura A,Takagi N,Artzt K,Abe K

更新日期：2012-11-29 00:00:00

abstract：:The local synthesis of transmembrane proteins underlies functional specialization of dendritic microdomains in neuronal plasticity. It is unclear whether these proteins have access to the complete machinery of the secretory pathway following local synthesis. In this study, we describe a probe called pGolt that allows ...

journal_title：Cell reports

authors： Mikhaylova M,Bera S,Kobler O,Frischknecht R,Kreutz MR

更新日期：2016-01-12 00:00:00

abstract：:Eosinophils mediate protection against filarial nematodes. Our results demonstrate that eosinophil extracellular traps (EETosis) are induced by microfilariae and infective L3 larvae of Litomosoides sigmodontis. These extracellular DNA traps inhibit microfilariae motility in a DNA- and contact-dependent manner in vitro...

journal_title：Cell reports

authors： Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP

更新日期：2021-01-12 00:00:00

abstract：:Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of host glycolysis in Mtb-infected macrophages, which is dependent on sustained u...

journal_title：Cell reports

authors： Hackett EE,Charles-Messance H,O'Leary SM,Gleeson LE,Muñoz-Wolf N,Case S,Wedderburn A,Johnston DGW,Williams MA,Smyth A,Ouimet M,Moore KJ,Lavelle EC,Corr SC,Gordon SV,Keane J,Sheedy FJ

更新日期：2020-01-07 00:00:00

abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...

journal_title：Cell reports

authors： Cai C,He HH,Gao S,Chen S,Yu Z,Gao Y,Chen S,Chen MW,Zhang J,Ahmed M,Wang Y,Metzger E,Schüle R,Liu XS,Brown M,Balk SP

更新日期：2014-12-11 00:00:00

abstract：:Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate a causal link with another liability factor: low expressi...

journal_title：Cell reports

authors： Bocarsly ME,da Silva E Silva D,Kolb V,Luderman KD,Shashikiran S,Rubinstein M,Sibley DR,Dobbs LK,Alvarez VA

更新日期：2019-10-29 00:00:00

abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...

journal_title：Cell reports

authors： Xiao T,Wongtrakoongate P,Trainor C,Felsenfeld G

更新日期：2015-09-08 00:00:00

abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...

journal_title：Cell reports

authors： Honoré FA,Méjean V,Genest O

更新日期：2017-04-25 00:00:00

abstract：:Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington's disease. Because expansions trigger the disease, contracting repeat length could be a possible approach to gene therapy for these disorders. Here, we show th...

journal_title：Cell reports

authors： Mosbach V,Poggi L,Viterbo D,Charpentier M,Richard GF

更新日期：2018-02-20 00:00:00