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Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo.

Abstract：

:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription driven by a pair of shadow enhancers, each enhancer of the pair separately, and each duplicated, using live imaging in Drosophila embryos. This set of constructs allows us to quantify the input-output function describing signal integration by two enhancers. We show that signal integration performed by these shadow enhancers and duplications varies across the expression pattern, implying that how their activities are combined depends on the transcriptional regulators bound to the enhancers in different parts of the embryo. Characterizing signal integration by multiple enhancers is a critical step in developing conceptual and computational models of gene expression at the locus level, where multiple enhancers control transcription together.

journal_name

Cell Rep

journal_title

Cell reports

authors

Scholes C,Biette KM,Harden TT,DePace AH

doi

10.1016/j.celrep.2019.01.115

subject

Has Abstract

pub_date

2019-02-26 00:00:00

pages

2407-2418.e5

issue

9

issn

2211-1247

pii

S2211-1247(19)30152-4

journal_volume

26

pub_type

杂志文章

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