当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Interferon-mediated innate immune responses against malaria parasite liver stages.

Interferon-mediated innate immune responses against malaria parasite liver stages.

Abstract：

:Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by these infection-engendered innate responses. This suppression was abrogated in mice deficient in IFNγ, the type I IFN α/β receptor (IFNAR), and interferon regulatory factor 3. Natural killer and CD49b(+)CD3(+) natural killer T (NKT) cells increased in the liver after a primary infection, and CD1d-restricted NKT cells, which secrete IFNγ, were critical in reducing liver-stage burden of a secondary infection. Lack of IFNAR signaling abrogated the increase in NKT cell numbers in the liver, showing a link between type I IFN signaling, cell recruitment, and subsequent parasite elimination. Our findings demonstrate innate immune sensing of malaria parasite liver-stage infection and that the ensuing innate responses can eliminate the parasite.

journal_name

Cell Rep

journal_title

Cell reports

authors

Miller JL,Sack BK,Baldwin M,Vaughan AM,Kappe SHI

doi

10.1016/j.celrep.2014.03.018

subject

Has Abstract

pub_date

2014-04-24 00:00:00

pages

436-447

issue

2

issn

2211-1247

pii

S2211-1247(14)00196-X

journal_volume

7

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Early Life Stress Drives Sex-Selective Impairment in Reversal Learning by Affecting Parvalbumin Interneurons in Orbitofrontal Cortex of Mice.

    abstract：:Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of fem...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.010

    authors： Goodwill HL,Manzano-Nieves G,LaChance P,Teramoto S,Lin S,Lopez C,Stevenson RJ,Theyel BB,Moore CI,Connors BW,Bath KG

    更新日期：2018-11-27 00:00:00

  • Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration.

    abstract：:The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.09.038

    authors： Korotkova DD,Lyubetsky VA,Ivanova AS,Rubanov LI,Seliverstov AV,Zverkov OA,Martynova NY,Nesterenko AM,Tereshina MB,Peshkin L,Zaraisky AG

    更新日期：2019-10-22 00:00:00

  • Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow.

    abstract：:Vitamin D (VD) is a known differentiating agent, but the role of VD receptor (VDR) is still incompletely described in acute myeloid leukemia (AML), whose treatment is based mostly on antimitotic chemotherapy. Here, we present an unexpected role of VDR in normal hematopoiesis and in leukemogenesis. Limited VDR expressi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.055

    authors： Paubelle E,Zylbersztejn F,Maciel TT,Carvalho C,Mupo A,Cheok M,Lieben L,Sujobert P,Decroocq J,Yokoyama A,Asnafi V,Macintyre E,Tamburini J,Bardet V,Castaigne S,Preudhomme C,Dombret H,Carmeliet G,Bouscary D,Ginzburg YZ

    更新日期：2020-01-21 00:00:00

  • Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.

    abstract：:Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene encoding the interleukin-11 receptor (IL-11R) have been described, but the underl...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.005

    authors： Agthe M,Brügge J,Garbers Y,Wandel M,Kespohl B,Arnold P,Flynn CM,Lokau J,Aparicio-Siegmund S,Bretscher C,Rose-John S,Waetzig GH,Putoczki T,Grötzinger J,Garbers C

    更新日期：2018-10-02 00:00:00

  • Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity.

    abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.026

    authors： Agarwal A,Zhang M,Trembak-Duff I,Unterbarnscheidt T,Radyushkin K,Dibaj P,Martins de Souza D,Boretius S,Brzózka MM,Steffens H,Berning S,Teng Z,Gummert MN,Tantra M,Guest PC,Willig KI,Frahm J,Hell SW,Bahn S,Rossner MJ

    更新日期：2014-08-21 00:00:00

  • Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.

    abstract：:Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.09.064

    authors： Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC

    更新日期：2015-11-10 00:00:00

  • RHON1 Co-transcriptionally Resolves R-Loops for Arabidopsis Chloroplast Genome Maintenance.

    abstract：:Preventing transcription-replication head-on conflict (HO-TRC)-triggered R-loop formation is essential for maintaining genome integrity in bacteria, plants, and mammals. The R-loop eraser RNase H can efficiently relax HO-TRCs. However, it is not clear how organisms resist HO-TRC-triggered R-loops when RNase H proteins...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.12.007

    authors： Yang Z,Li M,Sun Q

    更新日期：2020-01-07 00:00:00

  • Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.

    abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108448

    authors： Malkani S,Chin CR,Cekanaviciute E,Mortreux M,Okinula H,Tarbier M,Schreurs AS,Shirazi-Fard Y,Tahimic CGT,Rodriguez DN,Sexton BS,Butler D,Verma A,Bezdan D,Durmaz C,MacKay M,Melnick A,Meydan C,Li S,Garrett-Bakelman F,

    更新日期：2020-12-08 00:00:00

  • Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo.

    abstract：:Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-inflammatory microRNA-99a/146b/378a that are further increased in exosomes produced...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107881

    authors： Bouchareychas L,Duong P,Covarrubias S,Alsop E,Phu TA,Chung A,Gomes M,Wong D,Meechoovet B,Capili A,Yamamoto R,Nakauchi H,McManus MT,Carpenter S,Van Keuren-Jensen K,Raffai RL

    更新日期：2020-07-14 00:00:00

  • Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice.

    abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.079

    authors： von Ziegler LM,Selevsek N,Tweedie-Cullen RY,Kremer E,Mansuy IM

    更新日期：2018-03-20 00:00:00

  • Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons.

    abstract：:The NMDA spike is a long-lasting nonlinear phenomenon initiated locally in the dendritic branches of a variety of cortical neurons. It plays a key role in synaptic plasticity and in single-neuron computations. Combining dynamic system theory and computational approaches, we now explore how the timing of synaptic inhib...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.10.035

    authors： Doron M,Chindemi G,Muller E,Markram H,Segev I

    更新日期：2017-11-07 00:00:00

  • Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.

    abstract：:Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus ac...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.080

    authors： Avey D,Sankararaman S,Yim AKY,Barve R,Milbrandt J,Mitra RD

    更新日期：2018-09-25 00:00:00

  • Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene.

    abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organize membrane lipid rafts (MLRs) important for cell signaling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vivo. Genome-wide association studies localize a large proportion of ALS risk va...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108456

    authors： Cooper-Knock J,Zhang S,Kenna KP,Moll T,Franklin JP,Allen S,Nezhad HG,Iacoangeli A,Yacovzada NY,Eitan C,Hornstein E,Elhaik E,Celadova P,Bose D,Farhan S,Fishilevich S,Lancet D,Morrison KE,Shaw CE,Al-Chalabi A,Projec

    更新日期：2020-12-01 00:00:00

  • Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression.

    abstract：:Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in nutrient homeostasis has been largely neglected. In this study, ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.08.064

    authors： Chng WA,Sleiman MSB,Schüpfer F,Lemaitre B

    更新日期：2014-10-09 00:00:00

  • Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer.

    abstract：:CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.10.086

    authors： Knocke S,Fleischmann-Mundt B,Saborowski M,Manns MP,Kühnel F,Wirth TC,Woller N

    更新日期：2016-11-22 00:00:00

  • Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.

    abstract：:Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.059

    authors： Joost S,Jacob T,Sun X,Annusver K,La Manno G,Sur I,Kasper M

    更新日期：2018-10-16 00:00:00

  • Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.

    abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.001

    authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

    更新日期：2018-11-27 00:00:00

  • SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome.

    abstract：:SUMOylation is the covalent conjugation of SUMO polypeptides to cellular target proteins. Psmd1 is a subunit of the proteasomal 19S regulatory particle that acts as a docking site for Adrm1, another proteasome subunit that recruits ubiquitinated substrates for proteolysis. Here, we show that the SUMO deconjugating enz...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.009

    authors： Ryu H,Gygi SP,Azuma Y,Arnaoutov A,Dasso M

    更新日期：2014-06-26 00:00:00

  • FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair.

    abstract：:The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.005

    authors： Unno J,Itaya A,Taoka M,Sato K,Tomida J,Sakai W,Sugasawa K,Ishiai M,Ikura T,Isobe T,Kurumizaka H,Takata M

    更新日期：2014-05-22 00:00:00

  • Investigation of Proteomic and Phosphoproteomic Responses to Signaling Network Perturbations Reveals Functional Pathway Organizations in Yeast.

    abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.034

    authors： Li J,Paulo JA,Nusinow DP,Huttlin EL,Gygi SP

    更新日期：2019-11-12 00:00:00

  • Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance.

    abstract：:Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.083

    authors： Gilleron J,Bouget G,Ivanov S,Meziat C,Ceppo F,Vergoni B,Djedaini M,Soprani A,Dumas K,Jacquel A,Yvan-Charvet L,Venteclef N,Tanti JF,Cormont M

    更新日期：2018-12-18 00:00:00

  • Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder.

    abstract：:Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and publis...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.074

    authors： Takata A,Miyake N,Tsurusaki Y,Fukai R,Miyatake S,Koshimizu E,Kushima I,Okada T,Morikawa M,Uno Y,Ishizuka K,Nakamura K,Tsujii M,Yoshikawa T,Toyota T,Okamoto N,Hiraki Y,Hashimoto R,Yasuda Y,Saitoh S,Ohashi K,Sakai

    更新日期：2018-01-16 00:00:00

  • Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs.

    abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.062

    authors： Firth AL,Menon T,Parker GS,Qualls SJ,Lewis BM,Ke E,Dargitz CT,Wright R,Khanna A,Gage FH,Verma IM

    更新日期：2015-09-01 00:00:00

  • Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

    abstract：:Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.062

    authors： Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

    更新日期：2014-05-22 00:00:00

  • Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells.

    abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.054

    authors： Hinger SA,Cha DJ,Franklin JL,Higginbotham JN,Dou Y,Ping J,Shu L,Prasad N,Levy S,Zhang B,Liu Q,Weaver AM,Coffey RJ,Patton JG

    更新日期：2018-10-16 00:00:00

  • PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.

    abstract：:Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.044

    authors： Zhao XF,Kohen R,Parent R,Duan Y,Fisher GL,Korn MJ,Ji L,Wan G,Jin J,Püschel AW,Dolan DF,Parent JM,Corfas G,Murphy GG,Giger RJ

    更新日期：2018-01-09 00:00:00

  • Cilia-mediated hedgehog signaling in Drosophila.

    abstract：:Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during development, which has led to the assumption that cilia-mediated Hh sig...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.052

    authors： Kuzhandaivel A,Schultz SW,Alkhori L,Alenius M

    更新日期：2014-05-08 00:00:00

  • A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

    abstract：:Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish mic...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.018

    authors： Chiu IM,Morimoto ET,Goodarzi H,Liao JT,O'Keeffe S,Phatnani HP,Muratet M,Carroll MC,Levy S,Tavazoie S,Myers RM,Maniatis T

    更新日期：2013-07-25 00:00:00

  • Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase.

    abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.018

    authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

    更新日期：2015-12-22 00:00:00

  • Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.

    abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108661

    authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

    更新日期：2021-01-19 00:00:00