Abstract：
:In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in zebrafish are uncovered. The first involves precise spatiotemporal endothelial-neuroblast cytoneme contacts and Dll4-Notch signaling to restrain neuroblast proliferation. The second, instead, requires blood flow to trigger a transcriptional response that modifies neuroblast metabolic status and induces sensory neuron differentiation. In contrast, no role of sensory neurogenesis in vascular development is found, suggesting unidirectional signaling from vasculature to sensory neuroblasts. Altogether, we demonstrate that the cranial vasculature constitutes a niche component of the sensory ganglia that regulates the pace of their growth and differentiation dynamics.
journal_name
Cell Repjournal_title
Cell reportsauthors
Taberner L,Bañón A,Alsina Bdoi
10.1016/j.celrep.2020.107903subject
Has Abstractpub_date
2020-07-14 00:00:00pages
107903issue
2issn
2211-1247pii
S2211-1247(20)30884-6journal_volume
32pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear extinction defects. Postsynaptic NMDAR-dependent long-term depression (LTD) is sp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.089
更新日期：2018-06-26 00:00:00
abstract：:Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.018
更新日期：2018-09-04 00:00:00
abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.07.047
更新日期：2016-08-23 00:00:00
abstract：:Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature to undergo glucose-stimulated insulin secretion, but molecular regulation of thi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107687
更新日期：2020-05-26 00:00:00
abstract：:Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.108
更新日期：2017-11-21 00:00:00
abstract：:Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity; still, however, they often mediate distinct functional...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.053
更新日期：2019-09-24 00:00:00
abstract：:Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo. Here, we examine the controversy surrounding estimates of liver citric acid c...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107986
更新日期：2020-08-04 00:00:00
abstract：:Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.009
更新日期：2016-03-08 00:00:00
abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.04.009
更新日期：2013-05-30 00:00:00
abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.079
更新日期：2018-03-20 00:00:00
abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.068
更新日期：2020-04-14 00:00:00
abstract：:Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell soma. Here, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.005
更新日期：2019-03-26 00:00:00
abstract：:In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, bra...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.035
更新日期：2015-05-26 00:00:00
abstract：:Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.087
更新日期：2016-05-03 00:00:00
abstract：:Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication orig...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.046
更新日期：2020-03-10 00:00:00
abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.030
更新日期：2015-04-21 00:00:00
abstract：:Escape responses to threatening stimuli are vital for survival in all animal species. Larval zebrafish display fast escape responses when exposed to tactile, acoustic, and visual stimuli. However, their behavioral responses to chemosensory stimuli remain unknown. In this study, we found that carbon dioxide (CO2) induc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.019
更新日期：2018-01-30 00:00:00
abstract：:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.038
更新日期：2019-02-05 00:00:00
abstract：:Activation of CaV2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated CaV2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of phy...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.114
更新日期：2019-02-26 00:00:00
abstract：:Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition. Although such metabolic rep...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.09.036
更新日期：2015-10-27 00:00:00
abstract：:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.069
更新日期：2016-03-29 00:00:00
abstract：:Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and publis...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.12.074
更新日期：2018-01-16 00:00:00
abstract：:The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Noctur...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.011
更新日期：2018-01-30 00:00:00
abstract：:Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.024
更新日期：2017-08-08 00:00:00
abstract：:Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108532
更新日期：2021-01-05 00:00:00
abstract：:The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defect...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.06.004
更新日期：2015-07-07 00:00:00
abstract：:Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer's disease (FAD). Whether PS1 FAD mutat...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.10.018
更新日期：2013-11-27 00:00:00
abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.02.016
更新日期：2014-03-27 00:00:00
abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.085
更新日期：2018-05-22 00:00:00
abstract：:Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108047
更新日期：2020-08-18 00:00:00
