Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.

abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...

journal_title：Cell reports

authors： Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

更新日期：2018-11-27 00:00:00

abstract：:Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus ac...

journal_title：Cell reports

authors： Avey D,Sankararaman S,Yim AKY,Barve R,Milbrandt J,Mitra RD

更新日期：2018-09-25 00:00:00

abstract：:The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Throu...

journal_title：Cell reports

authors： Abrial M,Paffett-Lugassy N,Jeffrey S,Jordan D,O'Loughlin E,Frederick CJ 3rd,Burns CG,Burns CE

更新日期：2017-07-25 00:00:00

abstract：:Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as mature cell populations derived from ESCs. Luciferase (luc(+))-expres...

journal_title：Cell reports

authors： Pan Y,Leveson-Gower DB,de Almeida PE,Pierini A,Baker J,Florek M,Nishikii H,Kim BS,Ke R,Wu JC,Negrin RS

更新日期：2015-03-24 00:00:00

abstract：:Cognitive capacities decline with age, an event accompanied by the altered transcription of synaptic plasticity genes. Here, we show that the transcriptional induction of Bdnf by a mnemonic stimulus is impaired in aged hippocampal neurons. Mechanistically, this defect is due to reduced NMDA receptor (NMDAR)-mediated a...

journal_title：Cell reports

authors： Palomer E,Martín-Segura A,Baliyan S,Ahmed T,Balschun D,Venero C,Martin MG,Dotti CG

更新日期：2016-09-13 00:00:00

abstract：:Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

journal_title：Cell reports

authors： Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

更新日期：2014-04-10 00:00:00

abstract：:Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

journal_title：Cell reports

authors： Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

更新日期：2019-07-30 00:00:00

abstract：:Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell soma. Here, we ...

journal_title：Cell reports

authors： Wild AR,Sinnen BL,Dittmer PJ,Kennedy MJ,Sather WA,Dell'Acqua ML

更新日期：2019-03-26 00:00:00

abstract：:APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and mediate endosome association with cortical actin filaments. Loss of MY...

journal_title：Cell reports

authors： Masters TA,Tumbarello DA,Chibalina MV,Buss F

更新日期：2017-06-06 00:00:00

abstract：:CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...

journal_title：Cell reports

authors： Steinecke A,Kurabayashi N,Hayano Y,Ishino Y,Taniguchi H

更新日期：2019-07-09 00:00:00

abstract：:Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state that increases in severity ov...

journal_title：Cell reports

authors： Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR

更新日期：2020-04-28 00:00:00

abstract：:Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MSALL shotgun lipidomics to determine the molecular signatur...

journal_title：Cell reports

authors： May FJ,Baer LA,Lehnig AC,So K,Chen EY,Gao F,Narain NR,Gushchina L,Rose A,Doseff AI,Kiebish MA,Goodyear LJ,Stanford KI

更新日期：2017-02-07 00:00:00

abstract：:Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories. What regulates the specific characteristics of each type of synapse, in terms of number, morphology, and subcellular localization, remains to be u...

journal_title：Cell reports

authors： Sigoillot SM,Iyer K,Binda F,González-Calvo I,Talleur M,Vodjdani G,Isope P,Selimi F

更新日期：2015-02-10 00:00:00

abstract：:Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been descr...

journal_title：Cell reports

authors： Rodriguez J,Pilkington R,Garcia Munoz A,Nguyen LK,Rauch N,Kennedy S,Monsefi N,Herrero A,Taylor CT,von Kriegsheim A

更新日期：2016-03-22 00:00:00

abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...

journal_title：Cell reports

authors： Nishiguchi MA,Spencer CA,Leung DH,Leung TH

更新日期：2018-09-25 00:00:00

abstract：:Leptin has beneficial effects on glucose metabolism via actions in the hypothalamus, but the roles of specific subgroups of neurons responsible for these antidiabetic effects remain unresolved. We generated diabetic Lep(ob/ob) or Lepr(db/db) mice lacking or re-expressing leptin receptors (LepRb) in subgroups of neuron...

journal_title：Cell reports

authors： Gonçalves GH,Li W,Garcia AV,Figueiredo MS,Bjørbæk C

更新日期：2014-05-22 00:00:00

abstract：:Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in protection, the cellular processes underlying the slow acquisition of immunity remain unknown. Using mouse models, we show that severe malaria infection inhibits the es...

journal_title：Cell reports

authors： Ryg-Cornejo V,Ioannidis LJ,Ly A,Chiu CY,Tellier J,Hill DL,Preston SP,Pellegrini M,Yu D,Nutt SL,Kallies A,Hansen DS

更新日期：2016-01-05 00:00:00

abstract：:Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced neuron expressing a ligand-activated molecule, chemogenetics does not provide understanding about the antecedent circuit that drives that neuron's activity. For current approaches, this is ...

journal_title：Cell reports

authors： Ngo HB,Melo MR,Layfield S,Connelly AA,Bassi JK,Xie L,Menuet C,McDougall SJ,Bathgate RAD,Allen AM

更新日期：2020-09-15 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

journal_title：Cell reports

authors： Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2015-04-21 00:00:00

abstract：:The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is overexpressed in gliomas where it increases the efficiency of the DNA damage response (DDR) pathway b...

journal_title：Cell reports

authors： Ohba S,Johannessen TA,Chatla K,Yang X,Pieper RO,Mukherjee J

更新日期：2020-04-14 00:00:00

abstract：:Supernumerary centrosomes promote the assembly of abnormal spindles in many human cancers. The observation that modest changes in the centrosomal levels of Mps1 kinase can cause centrosome overduplication in human cells suggests the existence of a regulatory system that may tightly control its centrosomal stability. H...

journal_title：Cell reports

authors： Srinivas V,Kitagawa M,Wong J,Liao PJ,Lee SH

更新日期：2015-11-24 00:00:00

abstract：:The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...

journal_title：Cell reports

authors： Leung OM,Li J,Li X,Chan VW,Yang KY,Ku M,Ji L,Sun H,Waldmann H,Tian XY,Huang Y,Lau J,Zhou B,Lui KO

更新日期：2018-08-07 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Trimethylation at histone H3K27 is central to the polycomb repression system. Juxtaposed to H3K27 is a widely conserved phosphorylatable serine residue (H3S28) whose function is unclear. To assess the importance of H3S28, we generated a Drosophila H3 histone mutant with a serine-to-alanine mutation at position 28. H3S...

journal_title：Cell reports

authors： Yung PY,Stuetzer A,Fischle W,Martinez AM,Cavalli G

更新日期：2015-06-09 00:00:00

abstract：:Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engraft...

journal_title：Cell reports

authors： Diez JA,Arrojo E Drigo R,Zheng X,Stelmashenko OV,Chua M,Rodriguez-Diaz R,Fukuda M,Köhler M,Leibiger I,Tun SBB,Ali Y,Augustine GJ,Barathi VA,Berggren PO

更新日期：2017-08-08 00:00:00

abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...

journal_title：Cell reports

authors： Domsch K,Schröder J,Janeschik M,Schaub C,Lohmann I

更新日期：2021-01-05 00:00:00

abstract：:The activation of G-protein-coupled receptors (GPCRs) leads to the activation of mTORC2 in cell migration and metabolism. However, the mechanism that links GPCRs to mTORC2 remains unknown. Here, using Dictyostelium cells, we show that GPCR-mediated chemotactic stimulation induces hetero-oligomerization of phosphorylat...

journal_title：Cell reports

authors： Senoo H,Wai M,Matsubayashi HT,Sesaki H,Iijima M

更新日期：2020-11-24 00:00:00

abstract：:A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8+ TCR repertoires for two dominant viral epitopes: pp65495-503 (NLV) of cytomegalovirus and M158-66 (GIL...

journal_title：Cell reports

authors： Chen G,Yang X,Ko A,Sun X,Gao M,Zhang Y,Shi A,Mariuzza RA,Weng NP

更新日期：2017-04-18 00:00:00

abstract：:Recent evidence supports the presence of an L-glutamyl methyltransferase(s) in eukaryotic cells, but this enzyme class has been defined only in certain prokaryotic species. Here, we characterize the human C6orf211 gene product as "acidic residue methyltransferase-1" (Armt1), an enzyme that specifically targets prolife...

journal_title：Cell reports

authors： Perry JJ,Ballard GD,Albert AE,Dobrolecki LE,Malkas LH,Hoelz DJ

更新日期：2015-03-03 00:00:00

abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

journal_title：Cell reports

authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

更新日期：2020-10-20 00:00:00