Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function.

abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...

journal_title：Cell reports

authors： Hinger SA,Cha DJ,Franklin JL,Higginbotham JN,Dou Y,Ping J,Shu L,Prasad N,Levy S,Zhang B,Liu Q,Weaver AM,Coffey RJ,Patton JG

更新日期：2018-10-16 00:00:00

abstract：:Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChI...

journal_title：Cell reports

authors： Chang GS,Chen XA,Park B,Rhee HS,Li P,Han KH,Mishra T,Chan-Salis KY,Li Y,Hardison RC,Wang Y,Pugh BF

更新日期：2014-07-24 00:00:00

abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

journal_title：Cell reports

authors： Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

更新日期：2016-08-23 00:00:00

abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...

journal_title：Cell reports

authors： Jensen PA,Zhu Z,van Opijnen T

更新日期：2017-08-15 00:00:00

abstract：:Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...

journal_title：Cell reports

authors： Lee IH,Procko C,Lu Y,Shaham S

更新日期：2021-01-12 00:00:00

abstract：:The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...

journal_title：Cell reports

authors： Ramirez PW,Famiglietti M,Sowrirajan B,DePaula-Silva AB,Rodesch C,Barker E,Bosque A,Planelles V

更新日期：2014-06-26 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

journal_title：Cell reports

authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

更新日期：2017-09-12 00:00:00

abstract：:Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination,...

journal_title：Cell reports

authors： Jensen SK,Michaels NJ,Ilyntskyy S,Keough MB,Kovalchuk O,Yong VW

更新日期：2018-09-18 00:00:00

abstract：:During termination of translation, the nascent peptide is first released from the ribosome, which must be subsequently disassembled into subunits in a process known as ribosome recycling. In bacteria, termination and recycling are mediated by the translation factors RF, RRF, EF-G, and IF3, but their precise roles have...

journal_title：Cell reports

authors： Prabhakar A,Capece MC,Petrov A,Choi J,Puglisi JD

更新日期：2017-07-05 00:00:00

abstract：:α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

journal_title：Cell reports

authors： Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

更新日期：2017-12-05 00:00:00

abstract：:Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily serve to stabilize disease, and resistance eventually develops concomitant with progression. Here, we implicate metabolic symbiosis between tumor cells distal an...

journal_title：Cell reports

authors： Jiménez-Valerio G,Martínez-Lozano M,Bassani N,Vidal A,Ochoa-de-Olza M,Suárez C,García-Del-Muro X,Carles J,Viñals F,Graupera M,Indraccolo S,Casanovas O

更新日期：2016-05-10 00:00:00

abstract：:Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, th...

journal_title：Cell reports

authors： Petitjean H,Pawlowski SA,Fraine SL,Sharif B,Hamad D,Fatima T,Berg J,Brown CM,Jan LY,Ribeiro-da-Silva A,Braz JM,Basbaum AI,Sharif-Naeini R

更新日期：2015-11-10 00:00:00

abstract：:At presynaptic terminals, neurotransmitters are released by synaptic vesicle exocytosis at the active zone. In order to maintain efficient neurotransmission and proper synaptic structure, sites of vesicle fusion must be cleared rapidly by endocytosis. Therefore, the coupling of exo- and endocytosis is crucial. Despite...

journal_title：Cell reports

authors： Orlando M,Schmitz D,Rosenmund C,Herman MA

更新日期：2019-12-17 00:00:00

abstract：:ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2-/- mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2-/- mice are also severely osteopetrotic because of failed osteoc...

journal_title：Cell reports

authors： Izawa T,Rohatgi N,Fukunaga T,Wang QT,Silva MJ,Gardner MJ,McDaniel ML,Abumrad NA,Semenkovich CF,Teitelbaum SL,Zou W

更新日期：2015-06-16 00:00:00

abstract：:The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based appro...

journal_title：Cell reports

authors： Wingrove E,Liu ZZ,Patel KD,Arnal-Estapé A,Cai WL,Melnick MA,Politi K,Monteiro C,Zhu L,Valiente M,Kluger HM,Chiang VL,Nguyen DX

更新日期：2019-04-23 00:00:00

abstract：:Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activit...

journal_title：Cell reports

authors： Johnson SF,Cruz C,Greifenberg AK,Dust S,Stover DG,Chi D,Primack B,Cao S,Bernhardy AJ,Coulson R,Lazaro JB,Kochupurakkal B,Sun H,Unitt C,Moreau LA,Sarosiek KA,Scaltriti M,Juric D,Baselga J,Richardson AL,Rodig SJ,D

更新日期：2016-11-22 00:00:00

abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

journal_title：Cell reports

authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

更新日期：2018-11-27 00:00:00

abstract：:Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...

journal_title：Cell reports

authors： Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

更新日期：2019-02-19 00:00:00

abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...

journal_title：Cell reports

authors： Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W

更新日期：2019-06-18 00:00:00

abstract：:The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Noctur...

journal_title：Cell reports

authors： Stubblefield JJ,Gao P,Kilaru G,Mukadam B,Terrien J,Green CB

更新日期：2018-01-30 00:00:00

abstract：:The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...

journal_title：Cell reports

authors： Liu H,Li L,Wang W,Gong J,Yang X,Hu Z

更新日期：2018-02-27 00:00:00

abstract：:Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

journal_title：Cell reports

authors： Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

更新日期：2020-11-03 00:00:00

abstract：:Wnt signaling is intrinsic to mouse embryonic stem cell self-renewal. Therefore, it is surprising that reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is not strongly enhanced by Wnt signaling. Here, we demonstrate that active Wnt signaling inhibits the early stage of reprogramming to iPSCs, w...

journal_title：Cell reports

authors： Ho R,Papp B,Hoffman JA,Merrill BJ,Plath K

更新日期：2013-06-27 00:00:00

abstract：:Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide. Here, we present a cryoelectron microscopy (cryo-EM) reconstruction at 3.8 Å resol...

journal_title：Cell reports

authors： Bischoff L,Berninghausen O,Beckmann R

更新日期：2014-10-23 00:00:00

abstract：:Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene. We show that, although LRP1 transcript expression is upregulated in response to both sub-lethal and le...

journal_title：Cell reports

authors： Leslie PL,Franklin DA,Liu Y,Zhang Y

更新日期：2018-08-07 00:00:00

abstract：:Transgenic zebrafish embryos expressing tissue-specific green fluorescent protein (GFP) can provide an unlimited supply of primary embryonic cells. Agents that promote the differentiation of these cells may be beneficial for therapeutics. We report a high-throughput approach for screening small molecules that regulate...

journal_title：Cell reports

authors： Huang H,Lindgren A,Wu X,Liu NA,Lin S

更新日期：2012-09-27 00:00:00

abstract：:Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in ...

journal_title：Cell reports

authors： Rivera LB,Meyronet D,Hervieu V,Frederick MJ,Bergsland E,Bergers G

更新日期：2015-04-28 00:00:00

abstract：:In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, bra...

journal_title：Cell reports

authors： Reynaud E,Lahaye LL,Boulanger A,Petrova IM,Marquilly C,Flandre A,Martianez T,Privat M,Noordermeer JN,Fradkin LG,Dura JM

更新日期：2015-05-26 00:00:00

abstract：:The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcriptio...

journal_title：Cell reports

authors： Caygill EE,Brand AH

更新日期：2017-08-08 00:00:00