miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

Abstract:

:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit.

journal_name

Cell Rep

journal_title

Cell reports

authors

Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

doi

10.1016/j.celrep.2017.08.060

subject

Has Abstract

pub_date

2017-09-12 00:00:00

pages

2584-2597

issue

11

issn

2211-1247

pii

S2211-1247(17)31185-3

journal_volume

20

pub_type

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