当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.

The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells.

Abstract：

:Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chromatin processes has thus far remained elusive. Here, we map the genomic localization of all somatic replication-dependent H1 subtypes in human lung fibroblasts using an integrative DNA adenine methyltransferase identification (DamID) analysis. We find in general that H1.2 to H1.5 are depleted from CpG-dense regions and active regulatory regions. H1.1 shows a DamID binding profile distinct from the other subtypes, suggesting a unique function. H1 subtypes can mark specific domains and repressive regions, pointing toward a role for H1 in three-dimensional genome organization. Our work integrates H1 subtypes into the epigenome maps of human cells and provides a valuable resource to refine our understanding of the significance of H1 and its heterogeneity in the control of genome function.

journal_name

Cell Rep

journal_title

Cell reports

authors

Izzo A,Kamieniarz-Gdula K,Ramírez F,Noureen N,Kind J,Manke T,van Steensel B,Schneider R

doi

10.1016/j.celrep.2013.05.003

subject

Has Abstract

pub_date

2013-06-27 00:00:00

pages

2142-54

issue

6

issn

2211-1247

pii

S2211-1247(13)00220-9

journal_volume

3

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells.

    abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.067

    authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

    更新日期：2015-07-28 00:00:00

  • Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.

    abstract：:Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNAi phenotypes in Caenorhabditis elegans provides an excellent model to study this phenomenon, and although studies have...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.085

    authors： Woodhouse RM,Buchmann G,Hoe M,Harney DJ,Low JKK,Larance M,Boag PR,Ashe A

    更新日期：2018-11-20 00:00:00

  • Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution.

    abstract：:Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.04.017

    authors： Trevisan T,Pendin D,Montagna A,Bova S,Ghelli AM,Daga A

    更新日期：2018-05-08 00:00:00

  • Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

    abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.11.008

    authors： Cai C,He HH,Gao S,Chen S,Yu Z,Gao Y,Chen S,Chen MW,Zhang J,Ahmed M,Wang Y,Metzger E,Schüle R,Liu XS,Brown M,Balk SP

    更新日期：2014-12-11 00:00:00

  • Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years.

    abstract：:The fossil record is widely informative about evolution, but fossils are not systematically used to study the evolution of stem-cell-driven renewal. Here, we examined evolution of the continuous growth (hypselodonty) of rodent molar teeth, which is fuelled by the presence of dental stem cells. We studied occurrences o...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.03.064

    authors： Tapaltsyan V,Eronen JT,Lawing AM,Sharir A,Janis C,Jernvall J,Klein OD

    更新日期：2015-05-05 00:00:00

  • The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia.

    abstract：:Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organismal adaptation to hy...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.03.044

    authors： Hamanaka RB,Weinberg SE,Reczek CR,Chandel NS

    更新日期：2016-04-19 00:00:00

  • Molecular Basis of Zinc-Dependent Endocytosis of Human ZIP4 Transceptor.

    abstract：:Nutrient transporters can be rapidly removed from the cell surface via substrate-stimulated endocytosis as a way to control nutrient influx, but the molecular underpinnings are not well understood. In this work, we focus on zinc-dependent endocytosis of human ZIP4 (hZIP4), a zinc transporter that is essential for diet...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107582

    authors： Zhang C,Sui D,Zhang T,Hu J

    更新日期：2020-04-28 00:00:00

  • Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.

    abstract：:The role of neurotrophic factors as endogenous survival proteins for brain neurons remains contentious. In the cerebellum, the signals controlling survival of molecular layer interneurons (MLIs) are unknown, and direct evidence for the requirement of a full complement of MLIs for normal cerebellar function and motor l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.030

    authors： Sergaki MC,López-Ramos JC,Stagkourakis S,Gruart A,Broberger C,Delgado-García JM,Ibáñez CF

    更新日期：2017-06-06 00:00:00

  • Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

    abstract：:Huntington's disease (HD) is a monogenic neurodegenerative disorder representing an ideal candidate for gene silencing with oligonucleotide therapeutics (i.e., antisense oligonucleotides [ASOs] and small interfering RNAs [siRNAs]). Using an ultra-sensitive branched fluorescence in situ hybridization (FISH) method, we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.106

    authors： Didiot MC,Ferguson CM,Ly S,Coles AH,Smith AO,Bicknell AA,Hall LM,Sapp E,Echeverria D,Pai AA,DiFiglia M,Moore MJ,Hayward LJ,Aronin N,Khvorova A

    更新日期：2018-09-04 00:00:00

  • The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.

    abstract：:The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster CNS. Using Targeted DamID...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.038

    authors： Vissers JHA,Froldi F,Schröder J,Papenfuss AT,Cheng LY,Harvey KF

    更新日期：2018-11-06 00:00:00

  • Large-scale functional organization of long-range chromatin interaction networks.

    abstract：:Chromatin interactions play important roles in transcription regulation. To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chromatin interactions in human cells. We found that 40% of the total gen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.09.022

    authors： Sandhu KS,Li G,Poh HM,Quek YL,Sia YY,Peh SQ,Mulawadi FH,Lim J,Sikic M,Menghi F,Thalamuthu A,Sung WK,Ruan X,Fullwood MJ,Liu E,Csermely P,Ruan Y

    更新日期：2012-11-29 00:00:00

  • Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.

    abstract：:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.065

    authors： Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kuru

    更新日期：2017-01-17 00:00:00

  • Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.

    abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107865

    authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

    更新日期：2020-07-07 00:00:00

  • Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.

    abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.01.005

    authors： Song L,He Y,Ou J,Zhao Y,Li R,Cheng J,Lin CH,Ho MS

    更新日期：2017-01-31 00:00:00

  • SNAREs Controlling Vesicular Release of BDNF and Development of Callosal Axons.

    abstract：:At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.04.032

    authors： Shimojo M,Courchet J,Pieraut S,Torabi-Rander N,Sando R 3rd,Polleux F,Maximov A

    更新日期：2015-05-19 00:00:00

  • Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens.

    abstract：:A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8+ TCR repertoires for two dominant viral epitopes: pp65495-503 (NLV) of cytomegalovirus and M158-66 (GIL...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.072

    authors： Chen G,Yang X,Ko A,Sun X,Gao M,Zhang Y,Shi A,Mariuzza RA,Weng NP

    更新日期：2017-04-18 00:00:00

  • Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets.

    abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108661

    authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

    更新日期：2021-01-19 00:00:00

  • Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.

    abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.012

    authors： Deota S,Chattopadhyay T,Ramachandran D,Armstrong E,Camacho B,Maniyadath B,Fulzele A,Gonzalez-de-Peredo A,Denu JM,Kolthur-Seetharam U

    更新日期：2017-03-28 00:00:00

  • Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

    abstract：:Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.005

    authors： Erdel F,Kratz K,Willcox S,Griffith JD,Greene EC,de Lange T

    更新日期：2017-01-03 00:00:00

  • Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes.

    abstract：:How mutations in glial fibrillary acidic protein (GFAP) cause Alexander disease (AxD) remains elusive. We generated iPSCs from two AxD patients and corrected the GFAP mutations to examine the effects of mutant GFAP on human astrocytes. AxD astrocytes displayed GFAP aggregates, recapitulating the pathological hallmark ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.083

    authors： Jones JR,Kong L,Hanna MG 4th,Hoffman B,Krencik R,Bradley R,Hagemann T,Choi J,Doers M,Dubovis M,Sherafat MA,Bhattacharyya A,Kendziorski C,Audhya A,Messing A,Zhang SC

    更新日期：2018-10-23 00:00:00

  • A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis.

    abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108284

    authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

    更新日期：2020-10-20 00:00:00

  • Pten loss induces autocrine FGF signaling to promote skin tumorigenesis.

    abstract：:Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational activation of Fgf10 by ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.045

    authors： Hertzler-Schaefer K,Mathew G,Somani AK,Tholpady S,Kadakia MP,Chen Y,Spandau DF,Zhang X

    更新日期：2014-03-13 00:00:00

  • A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2.

    abstract：:The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate synapse elimination. Mutations in MEF2 pathways are implicated in autism spectrum disor...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.004

    authors： Andzelm MM,Vanness D,Greenberg ME,Linden DJ

    更新日期：2019-01-29 00:00:00

  • Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.

    abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.066

    authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

    更新日期：2018-04-10 00:00:00

  • Mechanotransmission and Mechanosensing of Human alpha-Actinin 1.

    abstract：:α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.11.040

    authors： Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

    更新日期：2017-12-05 00:00:00

  • Sleep Induction by Mechanosensory Stimulation in Drosophila.

    abstract：:People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108462

    authors： Öztürk-Çolak A,Inami S,Buchler JR,McClanahan PD,Cruz A,Fang-Yen C,Koh K

    更新日期：2020-12-01 00:00:00

  • Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes.

    abstract：:Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of single gene mutations' non-tissue-specific "core transcriptome signatures...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.031

    authors： Xu C,Ai D,Shi D,Suo S,Chen X,Yan Y,Cao Y,Zhang R,Sun N,Chen W,McDermott J,Zhang S,Zeng Y,Han JJ

    更新日期：2018-10-09 00:00:00

  • Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

    abstract：:The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.03.036

    authors： Cunningham TJ,Zhao X,Sandell LL,Evans SM,Trainor PA,Duester G

    更新日期：2013-05-30 00:00:00

  • miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.

    abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108436

    authors： Hines MJ,Coffre M,Mudianto T,Panduro M,Wigton EJ,Tegla C,Osorio-Vasquez V,Kageyama R,Benhamou D,Perez O,Bajwa S,McManus MT,Ansel KM,Melamed D,Koralov SB

    更新日期：2020-12-01 00:00:00

  • Cortical Polarity of the RING Protein PAR-2 Is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary.

    abstract：:Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.07.047

    authors： Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

    更新日期：2016-08-23 00:00:00