The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.

Abstract:

:The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster CNS. Using Targeted DamID, we find that Sd and Nerfin-1 occupy a highly overlapping set of target genes, including regulators of neural stem cell and neuron fate, and signaling pathways that regulate CNS development such as Notch and Hippo. Modulation of either Sd or Nerfin-1 activity causes medulla neurons to dedifferentiate to a stem cell-like state, and this is mediated at least in part by Notch pathway deregulation. Intriguingly, orthologs of Sd and Nerfin-1 have also been implicated in control of neuronal cell fate decisions in both worms and mammals. Our data indicate that this transcription factor pair exhibits remarkable biochemical and functional conservation across metazoans.

journal_name

Cell Rep

journal_title

Cell reports

authors

Vissers JHA,Froldi F,Schröder J,Papenfuss AT,Cheng LY,Harvey KF

doi

10.1016/j.celrep.2018.10.038

subject

Has Abstract

pub_date

2018-11-06 00:00:00

pages

1561-1576.e7

issue

6

issn

2211-1247

pii

S2211-1247(18)31614-0

journal_volume

25

pub_type

杂志文章
  • Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection.

    abstract::Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads to progressive CD8 T cell decline and dysfunction during viral p...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.08.065

    authors: Snell LM,Osokine I,Yamada DH,De la Fuente JR,Elsaesser HJ,Brooks DG

    更新日期:2016-09-20 00:00:00

  • Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis.

    abstract::Cytokinesis, the final step of cell division, begins with the formation of a cleavage furrow. How the mitotic spindle specifies the furrow at the equator in animal cells remains unknown. Current models propose that the concentration of the RhoGEF ECT2 at the spindle midzone and the equatorial plasma membrane directs f...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.11.029

    authors: Kotýnková K,Su KC,West SC,Petronczki M

    更新日期:2016-12-06 00:00:00

  • FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans.

    abstract::Most aging hypotheses assume the accumulation of damage, resulting in gradual physiological decline and, ultimately, death. Avoiding protein damage accumulation by enhanced turnover should slow down the aging process and extend the lifespan. However, lowering translational efficiency extends rather than shortens the l...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.07.088

    authors: Dhondt I,Petyuk VA,Cai H,Vandemeulebroucke L,Vierstraete A,Smith RD,Depuydt G,Braeckman BP

    更新日期:2016-09-13 00:00:00

  • Subcellular Imbalances in Synaptic Activity.

    abstract::The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local syna...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.01.024

    authors: Takahashi N,Kobayashi C,Ishikawa T,Ikegaya Y

    更新日期:2016-02-16 00:00:00

  • Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1.

    abstract::Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.03.068

    authors: Romero-Pozuelo J,Figlia G,Kaya O,Martin-Villalba A,Teleman AA

    更新日期:2020-04-14 00:00:00

  • GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

    abstract::Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2018.01.081

    authors: Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

    更新日期:2018-02-27 00:00:00

  • Transcriptional Regulation of Lipophorin Receptors Supports Neuronal Adaptation to Chronic Elevations of Activity.

    abstract::Activity-dependent modifications strongly influence neural development. However, molecular programs underlying their context and circuit-specific effects are not well understood. To study global transcriptional changes associated with chronic elevation of synaptic activity, we performed cell-type-specific transcriptom...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2018.10.016

    authors: Yin J,Gibbs M,Long C,Rosenthal J,Kim HS,Kim A,Sheng C,Ding P,Javed U,Yuan Q

    更新日期:2018-10-30 00:00:00

  • Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export.

    abstract::Naproxen is a non-steroidal anti-inflammatory drug that has previously been shown to exert antiviral activity against influenza A virus by inhibiting nucleoprotein (NP) binding to RNA. Here, we show that naproxen is a potential broad, multi-mechanistic anti-influenza virus therapeutic, as it inhibits influenza B virus...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.04.053

    authors: Zheng W,Fan W,Zhang S,Jiao P,Shang Y,Cui L,Mahesutihan M,Li J,Wang D,Gao GF,Sun L,Liu W

    更新日期:2019-05-07 00:00:00

  • Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

    abstract::The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show a...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.10.074

    authors: Dushukyan N,Dunn DM,Sager RA,Woodford MR,Loiselle DR,Daneshvar M,Baker-Williams AJ,Chisholm JD,Truman AW,Vaughan CK,Haystead TA,Bratslavsky G,Bourboulia D,Mollapour M

    更新日期:2017-11-14 00:00:00

  • The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition.

    abstract::Ectopic lipid deposition (ELD) is defined by excess fat storage in locations not classically associated with adipose tissue (AT) storage. ELD is positively correlated with insulin resistance and increased risk of metabolic disorders. ELD appears as lipid droplets or adipocytes, whose cell origin is unknown. We previou...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.03.038

    authors: Girousse A,Gil-Ortega M,Bourlier V,Bergeaud C,Sastourné-Arrey Q,Moro C,Barreau C,Guissard C,Vion J,Arnaud E,Pradère JP,Juin N,Casteilla L,Sengenès C

    更新日期:2019-04-09 00:00:00

  • Preventing Allograft Rejection by Targeting Immune Metabolism.

    abstract::Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition. Although such metabolic rep...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2015.09.036

    authors: Lee CF,Lo YC,Cheng CH,Furtmüller GJ,Oh B,Andrade-Oliveira V,Thomas AG,Bowman CE,Slusher BS,Wolfgang MJ,Brandacher G,Powell JD

    更新日期:2015-10-27 00:00:00

  • A humanized mouse identifies the bone marrow as a niche with low therapeutic IgG activity.

    abstract::Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2014.02.041

    authors: Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

    更新日期:2014-04-10 00:00:00

  • IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation.

    abstract::Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.10.077

    authors: He J,Yang Q,Xiao Q,Lei A,Li X,Zhou P,Liu T,Zhang L,Shi K,Yang Q,Dong J,Zhou J

    更新日期:2019-11-26 00:00:00

  • PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis.

    abstract::The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.12.105

    authors: Kong X,Tian H,Yu Q,Zhang F,Wang R,Gao S,Xu W,Liu J,Shani E,Fu C,Zhou G,Zhang L,Zhang X,Ding Z

    更新日期:2018-01-30 00:00:00

  • Autonomous CaMKII mediates both LTP and LTD using a mechanism for differential substrate site selection.

    abstract::Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2014.01.005

    authors: Coultrap SJ,Freund RK,O'Leary H,Sanderson JL,Roche KW,Dell'Acqua ML,Bayer KU

    更新日期:2014-02-13 00:00:00

  • Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability.

    abstract::The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5' ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study, we used accumulation of uncapped transcripts in cells inhibited ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2012.07.011

    authors: Mukherjee C,Patil DP,Kennedy BA,Bakthavachalu B,Bundschuh R,Schoenberg DR

    更新日期:2012-09-27 00:00:00

  • Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA.

    abstract::One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2012.05.015

    authors: Nissan X,Blondel S,Navarro C,Maury Y,Denis C,Girard M,Martinat C,De Sandre-Giovannoli A,Levy N,Peschanski M

    更新日期:2012-07-26 00:00:00

  • Reduced peroxisomal import triggers peroxisomal retrograde signaling.

    abstract::Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that pe...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.108653

    authors: Rackles E,Witting M,Forné I,Zhang X,Zacherl J,Schrott S,Fischer C,Ewbank JJ,Osman C,Imhof A,Rolland SG

    更新日期:2021-01-19 00:00:00

  • The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

    abstract::Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.03.009

    authors: Guarás A,Perales-Clemente E,Calvo E,Acín-Pérez R,Loureiro-Lopez M,Pujol C,Martínez-Carrascoso I,Nuñez E,García-Marqués F,Rodríguez-Hernández MA,Cortés A,Diaz F,Pérez-Martos A,Moraes CT,Fernández-Silva P,Trifunovic A,Navas

    更新日期:2016-04-05 00:00:00

  • A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

    abstract::Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2018.03.018

    authors: Bochukova EG,Lawler K,Croizier S,Keogh JM,Patel N,Strohbehn G,Lo KK,Humphrey J,Hokken-Koelega A,Damen L,Donze S,Bouret SG,Plagnol V,Farooqi IS

    更新日期:2018-03-27 00:00:00

  • PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum.

    abstract::The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium g...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.10.081

    authors: Florentin A,Cobb DW,Fishburn JD,Cipriano MJ,Kim PS,Fierro MA,Striepen B,Muralidharan V

    更新日期:2017-11-14 00:00:00

  • Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors.

    abstract::In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, bra...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2015.04.035

    authors: Reynaud E,Lahaye LL,Boulanger A,Petrova IM,Marquilly C,Flandre A,Martianez T,Privat M,Noordermeer JN,Fradkin LG,Dura JM

    更新日期:2015-05-26 00:00:00

  • PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

    abstract::Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely tuned to match changing energy requirements. To discover new pathways regulating glucose levels in vivo, we performed a larg...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2015.01.010

    authors: Nath AK,Ryu JH,Jin YN,Roberts LD,Dejam A,Gerszten RE,Peterson RT

    更新日期:2015-02-10 00:00:00

  • Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.

    abstract::The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2019.10.004

    authors: Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

    更新日期:2019-11-05 00:00:00

  • Circadian Clock Regulation of Developmental Time in the Kidney.

    abstract::We report the emergence of an endogenous circadian clock that regulates organogenesis in mouse fetal kidney. We detect circadian rhythms both in vivo with transcriptional profiling and ex vivo by bioluminescence. High-resolution structural analysis of embryonic explants reveals that global or local clock disruption re...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.107661

    authors: Dan H,Ruan T,Sampogna RV

    更新日期:2020-05-19 00:00:00

  • Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus.

    abstract::Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2016.02.080

    authors: Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

    更新日期:2016-03-29 00:00:00

  • TMEM163 Regulates ATP-Gated P2X Receptor and Behavior.

    abstract::Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Several modulators of ligand-gated ion channels have recently been identified, s...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2020.107704

    authors: Salm EJ,Dunn PJ,Shan L,Yamasaki M,Malewicz NM,Miyazaki T,Park J,Sumioka A,Hamer RRL,He WW,Morimoto-Tomita M,LaMotte RH,Tomita S

    更新日期:2020-06-02 00:00:00

  • Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling.

    abstract::The rate of protein synthesis varies according to the mRNA sequence in ways that affect gene expression. Global analysis of translational pausing is now possible with ribosome profiling. Here, we revisit an earlier report that Shine-Dalgarno sequences are the major determinant of translational pausing in bacteria. Usi...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2015.12.073

    authors: Mohammad F,Woolstenhulme CJ,Green R,Buskirk AR

    更新日期:2016-02-02 00:00:00

  • The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

    abstract::The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we ha...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2017.03.025

    authors: Mishima Y,Paiva B,Shi J,Park J,Manier S,Takagi S,Massoud M,Perilla-Glen A,Aljawai Y,Huynh D,Roccaro AM,Sacco A,Capelletti M,Detappe A,Alignani D,Anderson KC,Munshi NC,Prosper F,Lohr JG,Ha G,Freeman SS,Van Allen

    更新日期:2017-04-04 00:00:00

  • Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.

    abstract::Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period. We now show that high-level, spontaneous axonal release of the neur...

    journal_title:Cell reports

    pub_type: 杂志文章

    doi:10.1016/j.celrep.2015.01.032

    authors: Andreae LC,Burrone J

    更新日期:2015-02-17 00:00:00