当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years.

Continuously growing rodent molars result from a predictable quantitative evolutionary change over 50 million years.

Abstract：

:The fossil record is widely informative about evolution, but fossils are not systematically used to study the evolution of stem-cell-driven renewal. Here, we examined evolution of the continuous growth (hypselodonty) of rodent molar teeth, which is fuelled by the presence of dental stem cells. We studied occurrences of 3,500 North American rodent fossils, ranging from 50 million years ago (mya) to 2 mya. We examined changes in molar height to determine whether evolution of hypselodonty shows distinct patterns in the fossil record, and we found that hypselodont taxa emerged through intermediate forms of increasing crown height. Next, we designed a Markov simulation model, which replicated molar height increases throughout the Cenozoic and, moreover, evolution of hypselodonty. Thus, by extension, the retention of the adult stem cell niche appears to be a predictable quantitative rather than a stochastic qualitative process. Our analyses predict that hypselodonty will eventually become the dominant phenotype.

journal_name

Cell Rep

journal_title

Cell reports

authors

Tapaltsyan V,Eronen JT,Lawing AM,Sharir A,Janis C,Jernvall J,Klein OD

doi

10.1016/j.celrep.2015.03.064

subject

Has Abstract

pub_date

2015-05-05 00:00:00

pages

673-80

issue

5

issn

2211-1247

pii

S2211-1247(15)00355-1

journal_volume

11

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Long-Term Two-Photon Calcium Imaging of Neuronal Populations with Subcellular Resolution in Adult Non-human Primates.

    abstract：:Two-photon imaging with genetically encoded calcium indicators (GECIs) enables long-term observation of neuronal activity in vivo. However, there are very few studies of GECIs in primates. Here, we report a method for long-term imaging of a GECI, GCaMP6f, expressed from adeno-associated virus vectors in cortical neuro...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.10.050

    authors： Sadakane O,Masamizu Y,Watakabe A,Terada S,Ohtsuka M,Takaji M,Mizukami H,Ozawa K,Kawasaki H,Matsuzaki M,Yamamori T

    更新日期：2015-12-01 00:00:00

  • Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling.

    abstract：:T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell developme...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.015

    authors： Chea S,Schmutz S,Berthault C,Perchet T,Petit M,Burlen-Defranoux O,Goldrath AW,Rodewald HR,Cumano A,Golub R

    更新日期：2016-02-16 00:00:00

  • TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.

    abstract：:Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network ba...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.010

    authors： Brattås PL,Jönsson ME,Fasching L,Nelander Wahlestedt J,Shahsavani M,Falk R,Falk A,Jern P,Parmar M,Jakobsson J

    更新日期：2017-01-03 00:00:00

  • Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila.

    abstract：:Trimethylation at histone H3K27 is central to the polycomb repression system. Juxtaposed to H3K27 is a widely conserved phosphorylatable serine residue (H3S28) whose function is unclear. To assess the importance of H3S28, we generated a Drosophila H3 histone mutant with a serine-to-alanine mutation at position 28. H3S...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.04.055

    authors： Yung PY,Stuetzer A,Fischle W,Martinez AM,Cavalli G

    更新日期：2015-06-09 00:00:00

  • Subregion-Specific Proteomic Signature in the Hippocampus for Recognition Processes in Adult Mice.

    abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.079

    authors： von Ziegler LM,Selevsek N,Tweedie-Cullen RY,Kremer E,Mansuy IM

    更新日期：2018-03-20 00:00:00

  • Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.

    abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.11.023

    authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

    更新日期：2013-01-31 00:00:00

  • Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice.

    abstract：:Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.042

    authors： Caruso R,Ono M,Bunker ME,Núñez G,Inohara N

    更新日期：2019-06-11 00:00:00

  • Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation.

    abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.123

    authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

    更新日期：2018-05-08 00:00:00

  • Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface.

    abstract：:During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are av...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.109

    authors： Salvany-Celades M,van der Zwan A,Benner M,Setrajcic-Dragos V,Bougleux Gomes HA,Iyer V,Norwitz ER,Strominger JL,Tilburgs T

    更新日期：2019-05-28 00:00:00

  • Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.

    abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.034

    authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

    更新日期：2016-09-13 00:00:00

  • c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses.

    abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.060

    authors： Piovesan D,Tempany J,Di Pietro A,Baas I,Yiannis C,O'Donnell K,Chen Y,Peperzak V,Belz GT,Mackay CR,Smyth GK,Groom JR,Tarlinton DM,Good-Jacobson KL

    更新日期：2017-04-18 00:00:00

  • An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.

    abstract：:Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication orig...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.046

    authors： Amin A,Wu R,Cheung MH,Scott JF,Wang Z,Zhou Z,Liu C,Zhu G,Wong CK,Yu Z,Liang C

    更新日期：2020-03-10 00:00:00

  • Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake.

    abstract：:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.074

    authors： Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

    更新日期：2018-03-13 00:00:00

  • Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional Effects on Tissue Innervation.

    abstract：:The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their inner...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.02.016

    authors： McWilliams TG,Howard L,Wyatt S,Davies AM

    更新日期：2015-03-10 00:00:00

  • TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.

    abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.061

    authors： Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W

    更新日期：2019-06-18 00:00:00

  • Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

    abstract：:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close prox...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.007

    authors： De La Fuente AG,Lange S,Silva ME,Gonzalez GA,Tempfer H,van Wijngaarden P,Zhao C,Di Canio L,Trost A,Bieler L,Zaunmair P,Rotheneichner P,O'Sullivan A,Couillard-Despres S,Errea O,Mäe MA,Andrae J,He L,Keller A,Bátiz LF

    更新日期：2017-08-22 00:00:00

  • Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins.

    abstract：:Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease pat...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.036

    authors： Iversen R,Snir O,Stensland M,Kroll JE,Steinsbø Ø,Korponay-Szabó IR,Lundin KEA,de Souza GA,Sollid LM

    更新日期：2017-09-05 00:00:00

  • Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents.

    abstract：:Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.038

    authors： Olson OC,Kim H,Quail DF,Foley EA,Joyce JA

    更新日期：2017-04-04 00:00:00

  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.

    abstract：:Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe char...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.010

    authors： Beerman RW,Matty MA,Au GG,Looger LL,Choudhury KR,Keller PJ,Tobin DM

    更新日期：2015-12-15 00:00:00

  • Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.

    abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.012

    authors： Deota S,Chattopadhyay T,Ramachandran D,Armstrong E,Camacho B,Maniyadath B,Fulzele A,Gonzalez-de-Peredo A,Denu JM,Kolthur-Seetharam U

    更新日期：2017-03-28 00:00:00

  • Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.

    abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.067

    authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

    更新日期：2017-01-17 00:00:00

  • Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.

    abstract：:Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing (scRNA-seq) of the nucleus ac...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.080

    authors： Avey D,Sankararaman S,Yim AKY,Barve R,Milbrandt J,Mitra RD

    更新日期：2018-09-25 00:00:00

  • Post-termination Ribosome Intermediate Acts as the Gateway to Ribosome Recycling.

    abstract：:During termination of translation, the nascent peptide is first released from the ribosome, which must be subsequently disassembled into subunits in a process known as ribosome recycling. In bacteria, termination and recycling are mediated by the translation factors RF, RRF, EF-G, and IF3, but their precise roles have...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.06.028

    authors： Prabhakar A,Capece MC,Petrov A,Choi J,Puglisi JD

    更新日期：2017-07-05 00:00:00

  • CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.

    abstract：:Trimethylation of histone H3 at lysine-4 (H3K4me3) is associated with eukaryotic gene promoters and poises their transcriptional activation during development. To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 his...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.011

    authors： Yu C,Fan X,Sha QQ,Wang HH,Li BT,Dai XX,Shen L,Liu J,Wang L,Liu K,Tang F,Fan HY

    更新日期：2017-08-01 00:00:00

  • A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

    abstract：:A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs1696...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.020

    authors： Lewis A,Freeman-Mills L,de la Calle-Mustienes E,Giráldez-Pérez RM,Davis H,Jaeger E,Becker M,Hubner NC,Nguyen LN,Zeron-Medina J,Bond G,Stunnenberg HG,Carvajal JJ,Gomez-Skarmeta JL,Leedham S,Tomlinson I

    更新日期：2014-08-21 00:00:00

  • Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys.

    abstract：:Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media in which injecte...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.001

    authors： Kang Y,Ai Z,Duan K,Si C,Wang Y,Zheng Y,He J,Yin Y,Zhao S,Niu B,Zhu X,Liu L,Xiang L,Zhang L,Niu Y,Ji W,Li T

    更新日期：2018-11-27 00:00:00

  • Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes.

    abstract：:CXCR5 is a key marker of follicular helper T (TFH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5- CD4+ T cells with TFH-cell-like features. This CXCR5- subset becomes expanded in severe HIV infection and is characterized by the upregulation of activation markers...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.08.037

    authors： Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LF

    更新日期：2019-09-17 00:00:00

  • RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection.

    abstract：:A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a mechanism for genome uncoating. Viral core proteins were found to...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.09.003

    authors： Mercer J,Snijder B,Sacher R,Burkard C,Bleck CK,Stahlberg H,Pelkmans L,Helenius A

    更新日期：2012-10-25 00:00:00

  • Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

    abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.009

    authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

    更新日期：2013-01-31 00:00:00

  • Accessibility to Peptidoglycan Is Important for the Recognition of Gram-Positive Bacteria in Drosophila.

    abstract：:In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.04.103

    authors： Vaz F,Kounatidis I,Covas G,Parton RM,Harkiolaki M,Davis I,Filipe SR,Ligoxygakis P

    更新日期：2019-05-21 00:00:00