Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes.

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...

journal_title：Cell reports

authors： Salazar V,Jagger BW,Mongkolsapaya J,Burgomaster KE,Dejnirattisai W,Winkler ES,Fernandez E,Nelson CA,Fremont DH,Pierson TC,Crowe JE Jr,Screaton GR,Diamond MS

更新日期：2019-02-05 00:00:00

abstract：:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations...

journal_title：Cell reports

authors： Campbell JD,Yau C,Bowlby R,Liu Y,Brennan K,Fan H,Taylor AM,Wang C,Walter V,Akbani R,Byers LA,Creighton CJ,Coarfa C,Shih J,Cherniack AD,Gevaert O,Prunello M,Shen H,Anur P,Chen J,Cheng H,Hayes DN,Bullman S,Ped

更新日期：2018-04-03 00:00:00

abstract：:Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads to progressive CD8 T cell decline and dysfunction during viral p...

journal_title：Cell reports

authors： Snell LM,Osokine I,Yamada DH,De la Fuente JR,Elsaesser HJ,Brooks DG

更新日期：2016-09-20 00:00:00

abstract：:Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid up...

journal_title：Cell reports

authors： van den Berg R,Kooijman S,Noordam R,Ramkisoensing A,Abreu-Vieira G,Tambyrajah LL,Dijk W,Ruppert P,Mol IM,Kramar B,Caputo R,Puig LS,de Ruiter EM,Kroon J,Hoekstra M,van der Sluis RJ,Meijer OC,Willems van Dijk K,van Kerk

更新日期：2018-03-27 00:00:00

abstract：:Epigenomic mechanisms direct distinct gene expression programs for different cell types. Various in vivo tissues have been subjected to epigenomic analysis; however, these studies have been limited by cellular heterogeneity, resulting in composite gene expression and epigenomic profiles. Here, we introduce "NuTRAP," a...

journal_title：Cell reports

authors： Roh HC,Tsai LT,Lyubetskaya A,Tenen D,Kumari M,Rosen ED

更新日期：2017-01-24 00:00:00

abstract：:PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TI...

journal_title：Cell reports

authors： Young LM,Marzio A,Perez-Duran P,Reid DA,Meredith DN,Roberti D,Star A,Rothenberg E,Ueberheide B,Pagano M

更新日期：2015-10-20 00:00:00

abstract：:One critical event in reprogramming to pluripotency is erasure of the somatic transcriptional program of starting cells. Here, we present the proof of principle of a strategy for reprogramming to pluripotency facilitated by small molecules that interfere with the somatic transcriptional memory. We show that mild chemi...

journal_title：Cell reports

authors： Shao Z,Yao C,Khodadadi-Jamayran A,Xu W,Townes TM,Crowley MR,Hu K

更新日期：2016-09-20 00:00:00

abstract：:Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition, Smo gain-of-function mutations have limited their clinical implement...

journal_title：Cell reports

authors： Williams CH,Hempel JE,Hao J,Frist AY,Williams MM,Fleming JT,Sulikowski GA,Cooper MK,Chiang C,Hong CC

更新日期：2015-04-07 00:00:00

abstract：:CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...

journal_title：Cell reports

authors： Steinecke A,Kurabayashi N,Hayano Y,Ishino Y,Taniguchi H

更新日期：2019-07-09 00:00:00

abstract：:Kainate receptors (KARs) mediate postsynaptic currents with a key impact on neuronal excitability. However, the molecular determinants controlling KAR postsynaptic localization and stabilization are poorly understood. Here, we exploit optogenetic and single-particle tracking approaches to study the role of KAR conform...

journal_title：Cell reports

authors： Polenghi A,Nieus T,Guazzi S,Gorostiza P,Petrini EM,Barberis A

更新日期：2020-06-09 00:00:00

abstract：:MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells follow...

journal_title：Cell reports

authors： Chen Z,Stelekati E,Kurachi M,Yu S,Cai Z,Manne S,Khan O,Yang X,Wherry EJ

更新日期：2017-09-12 00:00:00

abstract：:The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in t...

journal_title：Cell reports

authors： Cunningham TJ,Zhao X,Sandell LL,Evans SM,Trainor PA,Duester G

更新日期：2013-05-30 00:00:00

abstract：:Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been descr...

journal_title：Cell reports

authors： Rodriguez J,Pilkington R,Garcia Munoz A,Nguyen LK,Rauch N,Kennedy S,Monsefi N,Herrero A,Taylor CT,von Kriegsheim A

更新日期：2016-03-22 00:00:00

abstract：:We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, includ...

journal_title：Cell reports

authors： Matarin M,Salih DA,Yasvoina M,Cummings DM,Guelfi S,Liu W,Nahaboo Solim MA,Moens TG,Paublete RM,Ali SS,Perona M,Desai R,Smith KJ,Latcham J,Fulleylove M,Richardson JC,Hardy J,Edwards FA

更新日期：2015-02-03 00:00:00

abstract：:In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 receptor, DRL (derailed), which is expressed in the dorsomedial lineages, bra...

journal_title：Cell reports

authors： Reynaud E,Lahaye LL,Boulanger A,Petrova IM,Marquilly C,Flandre A,Martianez T,Privat M,Noordermeer JN,Fradkin LG,Dura JM

更新日期：2015-05-26 00:00:00

abstract：:Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we demonstrate that activated microglia extensively associated with glutamatergic neuronal soma displace surrounding GABAergic presynapses in ...

journal_title：Cell reports

authors： Wan Y,Feng B,You Y,Yu J,Xu C,Dai H,Trapp BD,Shi P,Chen Z,Hu W

更新日期：2020-11-03 00:00:00

abstract：:In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing. The molecular details and mechanisms through which chromatin affects splicing, however, are stil...

journal_title：Cell reports

authors： Leung CS,Douglass SM,Morselli M,Obusan MB,Pavlyukov MS,Pellegrini M,Johnson TL

更新日期：2019-06-25 00:00:00

abstract：:Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothel...

journal_title：Cell reports

authors： Hammond TR,McEllin B,Morton PD,Raymond M,Dupree J,Gallo V

更新日期：2015-12-15 00:00:00

abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

journal_title：Cell reports

authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

更新日期：2020-06-30 00:00:00

abstract：:A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-specific in multiple can...

journal_title：Cell reports

authors： Stern JL,Paucek RD,Huang FW,Ghandi M,Nwumeh R,Costello JC,Cech TR

更新日期：2017-12-26 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

journal_title：Cell reports

authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

更新日期：2019-06-04 00:00:00

abstract：:Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...

journal_title：Cell reports

authors： Leon J,Moreno AJ,Garay BI,Chalkley RJ,Burlingame AL,Wang D,Dubal DB

更新日期：2017-08-08 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation...

journal_title：Cell reports

authors： Keppler SJ,Burbage M,Gasparrini F,Hartjes L,Aggarwal S,Massaad MJ,Geha RS,Bruckbauer A,Batista FD

更新日期：2018-07-17 00:00:00

abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

journal_title：Cell reports

authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

更新日期：2018-04-10 00:00:00

abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

journal_title：Cell reports

authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

更新日期：2013-01-31 00:00:00

abstract：:In Drosophila larvae, the class IV dendritic arborization (da) neurons are polymodal nociceptors. Here, we show that ppk26 (CG8546) plays an important role in mechanical nociception in class IV da neurons. Our immunohistochemical and functional results demonstrate that ppk26 is specifically expressed in class IV da ne...

journal_title：Cell reports

authors： Guo Y,Wang Y,Wang Q,Wang Z

更新日期：2014-11-20 00:00:00

abstract：:Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here, we introduce an integrative biochemical and genetic framework to dissect signal transduction events using multiple data types and, in particu...

journal_title：Cell reports

authors： Mertins P,Przybylski D,Yosef N,Qiao J,Clauser K,Raychowdhury R,Eisenhaure TM,Maritzen T,Haucke V,Satoh T,Akira S,Carr SA,Regev A,Hacohen N,Chevrier N

更新日期：2017-06-27 00:00:00

abstract：:The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyclosome (APC/C) to trigger an...

journal_title：Cell reports

authors： Ma HT,Poon RYC

更新日期：2018-02-06 00:00:00