Abstract:
:Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational activation of Fgf10 by Pten deletion is reversed by genetic disruption of the mTORC1 complex, which also prevents skin tumorigenesis in Pten mutants. We further show that ectopic expression of Fgf10 causes skin papillomas, whereas Pten deletion-induced skin tumors are inhibited by epidermal deletion of Fgfr2. Collectively, our data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors.
journal_name
Cell Repjournal_title
Cell reportsauthors
Hertzler-Schaefer K,Mathew G,Somani AK,Tholpady S,Kadakia MP,Chen Y,Spandau DF,Zhang Xdoi
10.1016/j.celrep.2014.01.045subject
Has Abstractpub_date
2014-03-13 00:00:00pages
818-26issue
5issn
2211-1247pii
S2211-1247(14)00079-5journal_volume
6pub_type
杂志文章相关文献
Cell Reports文献大全abstract::The rate of protein synthesis varies according to the mRNA sequence in ways that affect gene expression. Global analysis of translational pausing is now possible with ribosome profiling. Here, we revisit an earlier report that Shine-Dalgarno sequences are the major determinant of translational pausing in bacteria. Usi...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.12.073
更新日期:2016-02-02 00:00:00
abstract::In budding yeast, a mother cell can produce a finite number of daughter cells before it stops dividing and dies. Such entry into senescence is thought to result from a progressive decline in physiological function, including a loss of mitochondrial membrane potential (ΔΨ). Here, we developed a microfluidic device to m...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.11.013
更新日期:2013-12-26 00:00:00
abstract::Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.02.050
更新日期:2018-03-06 00:00:00
abstract::Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.10.072
更新日期:2019-11-26 00:00:00
abstract::In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity and selectivity of Pap1 activation by peroxides are not fully understood. Here, we demonstra...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.11.027
更新日期:2013-12-12 00:00:00
abstract::Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate chol...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.01.020
更新日期:2017-01-31 00:00:00
abstract::Shoot formation is accompanied by active cell proliferation and expansion, requiring that metabolic state adapts to developmental control. Despite the importance of such metabolic reprogramming, it remains unclear how development and metabolism are integrated. Here, we show that disruption of ANGUSTIFOLIA3 orthologs (...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108127
更新日期:2020-09-08 00:00:00
abstract::The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.02.079
更新日期:2018-03-20 00:00:00
abstract::Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathway is central to endothelial cell angiogenic responses, and it is activated by ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.008
更新日期:2018-05-08 00:00:00
abstract::Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which is increased in diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), which when mutated is associated with neurodevelopmental disorders. S...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.09.067
更新日期:2016-10-18 00:00:00
abstract::The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adul...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.10.037
更新日期:2013-11-27 00:00:00
abstract::Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining gen...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.02.040
更新日期:2019-03-12 00:00:00
abstract::We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.04.037
更新日期:2016-05-17 00:00:00
abstract::Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.085
更新日期:2018-05-22 00:00:00
abstract::Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in nutrient homeostasis has been largely neglected. In this study, ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.08.064
更新日期:2014-10-09 00:00:00
abstract::Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs. BRD4 inhibition resu...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.08.055
更新日期:2014-10-09 00:00:00
abstract::Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.10.005
更新日期:2014-11-06 00:00:00
abstract::The neurodevelopmental origin of hyperactivity disorder has been suggested to involve the dopaminergic system, but the underlying mechanisms are still unknown. Here, transcription factors Lmx1a and Lmx1b are shown to be essential for midbrain dopaminergic (mDA) neuron excitatory synaptic inputs and dendritic developme...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.01.084
更新日期:2020-02-18 00:00:00
abstract::Stable wakefulness requires orexin/hypocretin neurons (OHNs) and OHR2 receptors. OHNs sense diverse environmental cues and control arousal accordingly. For unknown reasons, OHNs contain multiple excitatory transmitters, including OH peptides and glutamate. To analyze their cotransmission within computational framework...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.03.055
更新日期:2014-05-08 00:00:00
abstract::Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, and dengue virus....
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.06.076
更新日期:2015-08-04 00:00:00
abstract::Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). Howev...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107579
更新日期:2020-05-05 00:00:00
abstract::Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.03.103
更新日期:2019-04-23 00:00:00
abstract::Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear extinction defects. Postsynaptic NMDAR-dependent long-term depression (LTD) is sp...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.05.089
更新日期:2018-06-26 00:00:00
abstract::S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.02.016
更新日期:2014-03-27 00:00:00
abstract::The Drosophila pharyngeal taste organs are poorly characterized despite their location at important sites for monitoring food quality. Functional analysis of pharyngeal neurons has been hindered by the paucity of molecular tools to manipulate them, as well as their relative inaccessibility for neurophysiological inves...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.11.041
更新日期:2017-12-05 00:00:00
abstract::The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.03.082
更新日期:2017-04-25 00:00:00
abstract::The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplif...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.02.078
更新日期:2016-03-29 00:00:00
abstract::Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, th...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.09.080
更新日期:2015-11-10 00:00:00
abstract::Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, espe...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.11.010
更新日期:2014-12-24 00:00:00
abstract::Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.01.115
更新日期:2019-02-26 00:00:00