miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.

abstract：:Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

journal_title：Cell reports

authors： Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

更新日期：2014-04-10 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT, but the relation among the markers is not known. Here, we used t...

journal_title：Cell reports

authors： Gulyaeva O,Nguyen H,Sambeat A,Heydari K,Sul HS

更新日期：2018-10-23 00:00:00

abstract：:The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

journal_title：Cell reports

authors： Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

更新日期：2019-07-16 00:00:00

abstract：:Although our understanding of centromere maintenance, marked by the histone H3 variant CenH3(CENP-A) in most eukaryotes, has progressed, the mechanism underlying the de novo formation of centromeres remains unclear. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and C...

journal_title：Cell reports

authors： Tachiwana H,Müller S,Blümer J,Klare K,Musacchio A,Almouzni G

更新日期：2015-04-07 00:00:00

abstract：:The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...

journal_title：Cell reports

authors： Ramirez PW,Famiglietti M,Sowrirajan B,DePaula-Silva AB,Rodesch C,Barker E,Bosque A,Planelles V

更新日期：2014-06-26 00:00:00

abstract：:Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete fungicidal mechanisms are not fully understood. Here, we employ a systems biology approach to identify a common oxidative-damage cellular death pathway trigger...

journal_title：Cell reports

authors： Belenky P,Camacho D,Collins JJ

更新日期：2013-02-21 00:00:00

abstract：:RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII rec...

journal_title：Cell reports

authors： Puliyappadamba VT,Chakraborty S,Chauncey SS,Li L,Hatanpaa KJ,Mickey B,Noorani S,Shu HK,Burma S,Boothman DA,Habib AA

更新日期：2013-08-29 00:00:00

abstract：:Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step in rescuing stalled ribosomes. Here we identify NONU-1 as a factor required for translation surveillance pathways including no-go and...

journal_title：Cell reports

authors： Glover ML,Burroughs AM,Monem PC,Egelhofer TA,Pule MN,Aravind L,Arribere JA

更新日期：2020-03-31 00:00:00

abstract：:Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and isocitrate dehydrogenase 1 (IDH1) mutations are tumorigenic, in part, because...

journal_title：Cell reports

authors： Jiang B,Zhang J,Xia J,Zhao W,Wu Y,Shi M,Luo L,Zhou H,Chen A,Ma H,Zhao Q,Suleman M,Lin F,Zhou L,Wang J,Zhang Y,He Y,Li X,Hung LM,Mak TW,Li Q

更新日期：2017-04-11 00:00:00

abstract：:The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map...

journal_title：Cell reports

authors： Weyn-Vanhentenryck SM,Mele A,Yan Q,Sun S,Farny N,Zhang Z,Xue C,Herre M,Silver PA,Zhang MQ,Krainer AR,Darnell RB,Zhang C

更新日期：2014-03-27 00:00:00

abstract：:Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to regulate neurogenesis and synaptic maturation at perinatal and postnatal stages. However, microglia invade the brain during mid-embryoge...

journal_title：Cell reports

authors： Squarzoni P,Oller G,Hoeffel G,Pont-Lezica L,Rostaing P,Low D,Bessis A,Ginhoux F,Garel S

更新日期：2014-09-11 00:00:00

abstract：:Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, and this may bias sub...

journal_title：Cell reports

authors： Wang L,Hiler D,Xu B,AlDiri I,Chen X,Zhou X,Griffiths L,Valentine M,Shirinifard A,Sablauer A,Thiagarajan S,Barabas ME,Zhang J,Johnson D,Frase S,Dyer MA

更新日期：2018-03-06 00:00:00

abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

journal_title：Cell reports

authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

更新日期：2020-07-07 00:00:00

abstract：:The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bo...

journal_title：Cell reports

authors： Wang CQ,Krishnan V,Tay LS,Chin DW,Koh CP,Chooi JY,Nah GS,Du L,Jacob B,Yamashita N,Lai SK,Tan TZ,Mori S,Tanuichi I,Tergaonkar V,Ito Y,Osato M

更新日期：2014-08-07 00:00:00

abstract：:Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature to undergo glucose-stimulated insulin secretion, but molecular regulation of thi...

journal_title：Cell reports

authors： Velazco-Cruz L,Goedegebuure MM,Maxwell KG,Augsornworawat P,Hogrebe NJ,Millman JR

更新日期：2020-05-26 00:00:00

abstract：:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocamp...

journal_title：Cell reports

authors： Zhao R,Grunke SD,Keralapurath MM,Yetman MJ,Lam A,Lee TC,Sousounis K,Jiang Y,Swing DA,Tessarollo L,Ji D,Jankowsky JL

更新日期：2016-07-19 00:00:00

abstract：:The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid cells with unique hap...

journal_title：Cell reports

authors： Vázquez-García I,Salinas F,Li J,Fischer A,Barré B,Hallin J,Bergström A,Alonso-Perez E,Warringer J,Mustonen V,Liti G

更新日期：2017-10-17 00:00:00

abstract：:Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with various parameters of glucose homeostasis and susceptibility to type 2 diabete...

journal_title：Cell reports

authors： Wigger L,Cruciani-Guglielmacci C,Nicolas A,Denom J,Fernandez N,Fumeron F,Marques-Vidal P,Ktorza A,Kramer W,Schulte A,Le Stunff H,Liechti R,Xenarios I,Vollenweider P,Waeber G,Uphues I,Roussel R,Magnan C,Ibberson M,Th

更新日期：2017-02-28 00:00:00

abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...

journal_title：Cell reports

authors： Wang X,Yu R,Wang J,Lin Z,Han X,Deng Z,Fan L,He H,Deng XW,Chen H

更新日期：2020-04-21 00:00:00

abstract：:Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment and enhanced risk of fem...

journal_title：Cell reports

authors： Goodwill HL,Manzano-Nieves G,LaChance P,Teramoto S,Lin S,Lopez C,Stevenson RJ,Theyel BB,Moore CI,Connors BW,Bath KG

更新日期：2018-11-27 00:00:00

abstract：:Cellular differentiation is associated with dynamic chromatin remodeling in establishing a cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and replication-dependent histone H3 variant H3t is essential for very early stages of spermatogenesis. H3t gene deficiency leads to azoospermia b...

journal_title：Cell reports

authors： Ueda J,Harada A,Urahama T,Machida S,Maehara K,Hada M,Makino Y,Nogami J,Horikoshi N,Osakabe A,Taguchi H,Tanaka H,Tachiwana H,Yao T,Yamada M,Iwamoto T,Isotani A,Ikawa M,Tachibana T,Okada Y,Kimura H,Ohkawa Y,Kuru

更新日期：2017-01-17 00:00:00

abstract：:Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intrigui...

journal_title：Cell reports

authors： Wang Y,Jones-Tabah J,Chakravarty P,Stewart A,Muotri A,Laposa RR,Svejstrup JQ

更新日期：2016-03-22 00:00:00

abstract：:The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM...

journal_title：Cell reports

authors： Vaughan L,Tan CT,Chapman A,Nonaka D,Mack NA,Smith D,Booton R,Hurlstone AF,Malliri A

更新日期：2015-01-06 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that exhibits motor and non-motor symptoms, as well as pathological hallmarks, including dopaminergic (DA) neuron death and formation of α-synuclein (α-Syn) Lewy bodies. Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-...

journal_title：Cell reports

authors： Song L,He Y,Ou J,Zhao Y,Li R,Cheng J,Lin CH,Ho MS

更新日期：2017-01-31 00:00:00

abstract：:Complex interactions between immune cells are an important component in the induction of obesity. Here, we show that Il2rg-/-Rag2-/- mice lacking all lymphocytes are resistant to diet-induced obesity. Transplantation of bone marrow cells from Rag2-/- mice, which lack only acquired immune cells, into Il2rg-/-Rag2-/- mi...

journal_title：Cell reports

authors： Sasaki T,Moro K,Kubota T,Kubota N,Kato T,Ohno H,Nakae S,Saito H,Koyasu S

更新日期：2019-07-02 00:00:00

abstract：:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...

journal_title：Cell reports

authors： Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

更新日期：2017-03-21 00:00:00

abstract：:Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of mem...

journal_title：Cell reports

authors： Chwastek G,Surma MA,Rizk S,Grosser D,Lavrynenko O,Rucińska M,Jambor H,Sáenz J

更新日期：2020-09-22 00:00:00

abstract：:In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also main...

journal_title：Cell reports

authors： Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

更新日期：2018-04-24 00:00:00