Abstract：
:Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of membrane adaptation. Using shotgun lipidomics, we examine the simple yet, as we show here, adaptive lipidome of the plant-associated Gram-negative bacterium Methylobacterium extorquens. We observe that minimally 11 lipids account for 90% of total variability, thus constraining the upper limit of variable lipids required for an adaptive living membrane. Through lipid features analysis, we reveal that acyl chain remodeling is not evenly distributed across lipid classes, resulting in headgroup-specific effects of acyl chain variability on membrane properties. Results herein implicate headgroup-specific acyl chain remodeling as a mechanism for fine-tuning the membrane's physical state and provide a resource for using M. extorquens to explore the design principles of living membranes.
journal_name
Cell Repjournal_title
Cell reportsauthors
Chwastek G,Surma MA,Rizk S,Grosser D,Lavrynenko O,Rucińska M,Jambor H,Sáenz Jdoi
10.1016/j.celrep.2020.108165subject
Has Abstractpub_date
2020-09-22 00:00:00pages
108165issue
12issn
2211-1247pii
S2211-1247(20)31154-2journal_volume
32pub_type
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