Engraftment of embryonic stem cells and differentiated progeny by host conditioning with total lymphoid irradiation and regulatory T cells.

abstract：:The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

journal_title：Cell reports

authors： Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

更新日期：2020-04-21 00:00:00

abstract：:Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

journal_title：Cell reports

authors： Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

更新日期：2019-07-30 00:00:00

abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

journal_title：Cell reports

authors： Furter M,Sellin ME,Hansson GC,Hardt WD

更新日期：2019-05-28 00:00:00

abstract：:The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4...

journal_title：Cell reports

authors： Clottu AS,Mathias A,Sailer AW,Schluep M,Seebach JD,Du Pasquier R,Pot C

更新日期：2017-01-03 00:00:00

abstract：:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations...

journal_title：Cell reports

authors： Campbell JD,Yau C,Bowlby R,Liu Y,Brennan K,Fan H,Taylor AM,Wang C,Walter V,Akbani R,Byers LA,Creighton CJ,Coarfa C,Shih J,Cherniack AD,Gevaert O,Prunello M,Shen H,Anur P,Chen J,Cheng H,Hayes DN,Bullman S,Ped

更新日期：2018-04-03 00:00:00

abstract：:Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Several modulators of ligand-gated ion channels have recently been identified, s...

journal_title：Cell reports

authors： Salm EJ,Dunn PJ,Shan L,Yamasaki M,Malewicz NM,Miyazaki T,Park J,Sumioka A,Hamer RRL,He WW,Morimoto-Tomita M,LaMotte RH,Tomita S

更新日期：2020-06-02 00:00:00

abstract：:Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA d...

journal_title：Cell reports

authors： Chen CF,Ruiz-Vega R,Vasudeva P,Espitia F,Krasieva TB,de Feraudy S,Tromberg BJ,Huang S,Garner CP,Wu J,Hoon DS,Ganesan AK

更新日期：2017-03-07 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to pertur...

journal_title：Cell reports

authors： Kringelbach ML,Deco G

更新日期：2020-09-08 00:00:00

abstract：:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, th...

journal_title：Cell reports

authors： Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJ

更新日期：2019-02-05 00:00:00

abstract：:We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene). Microarray data were validated by qPCR and by comparison to human studies, includ...

journal_title：Cell reports

authors： Matarin M,Salih DA,Yasvoina M,Cummings DM,Guelfi S,Liu W,Nahaboo Solim MA,Moens TG,Paublete RM,Ali SS,Perona M,Desai R,Smith KJ,Latcham J,Fulleylove M,Richardson JC,Hardy J,Edwards FA

更新日期：2015-02-03 00:00:00

abstract：:Synapsin III (SynIII) is a phosphoprotein that is highly expressed at early stages of neuronal development. Whereas in vitro evidence suggests a role for SynIII in neuronal differentiation, in vivo evidence is lacking. Here, we demonstrate that in vivo downregulation of SynIII expression affects neuronal migration and...

journal_title：Cell reports

authors： Perlini LE,Szczurkowska J,Ballif BA,Piccini A,Sacchetti S,Giovedì S,Benfenati F,Cancedda L

更新日期：2015-04-14 00:00:00

abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...

journal_title：Cell reports

authors： Deota S,Chattopadhyay T,Ramachandran D,Armstrong E,Camacho B,Maniyadath B,Fulzele A,Gonzalez-de-Peredo A,Denu JM,Kolthur-Seetharam U

更新日期：2017-03-28 00:00:00

abstract：:The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defect...

journal_title：Cell reports

authors： Gonzalez J,Qi H,Liu N,Lin H

更新日期：2015-07-07 00:00:00

abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...

journal_title：Cell reports

authors： Mellert H,Espinosa JM

更新日期：2013-05-30 00:00:00

abstract：:Spatiotemporal protein reorganization at DNA damage sites induced by genotoxic chemotherapies is crucial for DNA damage response (DDR), which influences treatment response by directing cancer cell fate. This process is orchestrated by valosin-containing protein (VCP), an AAA+ ATPase that extracts polyubiquinated chrom...

journal_title：Cell reports

authors： Zhu C,Rogers A,Asleh K,Won J,Gao D,Leung S,Li S,Vij KR,Zhu J,Held JM,You Z,Nielsen TO,Shao J

更新日期：2020-06-09 00:00:00

abstract：:Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studie...

journal_title：Cell reports

authors： Selvadurai HJ,Luis E,Desai K,Lan X,Vladoiu MC,Whitley O,Galvin C,Vanner RJ,Lee L,Whetstone H,Kushida M,Nowakowski T,Diamandis P,Hawkins C,Bader G,Kriegstein A,Taylor MD,Dirks PB

更新日期：2020-04-14 00:00:00

abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

journal_title：Cell reports

authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

更新日期：2018-08-28 00:00:00

abstract：:Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extr...

journal_title：Cell reports

authors： Zhao H,Michelot A,Koskela EV,Tkach V,Stamou D,Drubin DG,Lappalainen P

更新日期：2013-09-26 00:00:00

abstract：:CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...

journal_title：Cell reports

authors： Steinecke A,Kurabayashi N,Hayano Y,Ishino Y,Taniguchi H

更新日期：2019-07-09 00:00:00

abstract：:During cell division, the molecular motor Eg5 crosslinks overlapping antiparallel microtubules and pushes them apart to separate mitotic spindle poles. Dynein has been proposed as a direct antagonist of Eg5 at the spindle equator, pulling on antiparallel microtubules and favoring spindle collapse. Some of the experime...

journal_title：Cell reports

authors： Florian S,Mayer TU

更新日期：2012-05-31 00:00:00

abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...

journal_title：Cell reports

authors： Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W

更新日期：2019-06-18 00:00:00

abstract：:Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of transcriptomics to predict biological age. Using age-stratified human tissue transcriptomes and m...

journal_title：Cell reports

authors： Janssens GE,Lin XX,Millan-Ariño L,Kavšek A,Sen I,Seinstra RI,Stroustrup N,Nollen EAA,Riedel CG

更新日期：2019-04-09 00:00:00

abstract：:Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes E...

journal_title：Cell reports

authors： Howell KA,Qiu X,Brannan JM,Bryan C,Davidson E,Holtsberg FW,Wec AZ,Shulenin S,Biggins JE,Douglas R,Enterlein SG,Turner HL,Pallesen J,Murin CD,He S,Kroeker A,Vu H,Herbert AS,Fusco ML,Nyakatura EK,Lai JR,Keck ZY,

更新日期：2016-05-17 00:00:00

abstract：:The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is overexpressed in gliomas where it increases the efficiency of the DNA damage response (DDR) pathway b...

journal_title：Cell reports

authors： Ohba S,Johannessen TA,Chatla K,Yang X,Pieper RO,Mukherjee J

更新日期：2020-04-14 00:00:00

abstract：:Calcium is a key regulator of mitochondrial function under both normal and pathological conditions. The mechanisms linking metabolic activity to mitochondrial Ca2+ signaling remain elusive, however. Here, by monitoring mitochondrial Ca2+ transients while manipulating mitochondrial membrane potential (ΔΨm), we found th...

journal_title：Cell reports

authors： Kostic M,Katoshevski T,Sekler I

更新日期：2018-12-18 00:00:00

abstract：:We provide a catalog for the effects of the human kinome on cell survival in response to DNA-damaging agents, covering all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA-damaging agents, including seven commonly used chemotherapeutics, we identified examples of vulnerabilit...

journal_title：Cell reports

authors： Owusu M,Bannauer P,Ferreira da Silva J,Mourikis TP,Jones A,Májek P,Caldera M,Wiedner M,Lardeau CH,Mueller AC,Menche J,Kubicek S,Ciccarelli FD,Loizou JI

更新日期：2019-01-15 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organismal adaptation to hy...

journal_title：Cell reports

authors： Hamanaka RB,Weinberg SE,Reczek CR,Chandel NS

更新日期：2016-04-19 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Emerging evidence has shown that noncoding RNAs, particularly microRNAs (miRNAs), contribute to the pathogenesis of mood and anxiety disorders, although the molecular mechanisms are poorly understood. Here, we show that altered levels of miR-17-92 in adult hippocampal neural progenitors have a significant impact on ne...

journal_title：Cell reports

authors： Jin J,Kim SN,Liu X,Zhang H,Zhang C,Seo JS,Kim Y,Sun T

更新日期：2016-08-09 00:00:00