Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

abstract：:CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...

journal_title：Cell reports

authors： Knocke S,Fleischmann-Mundt B,Saborowski M,Manns MP,Kühnel F,Wirth TC,Woller N

更新日期：2016-11-22 00:00:00

abstract：:A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

journal_title：Cell reports

authors： Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

更新日期：2020-12-15 00:00:00

abstract：:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocamp...

journal_title：Cell reports

authors： Zhao R,Grunke SD,Keralapurath MM,Yetman MJ,Lam A,Lee TC,Sousounis K,Jiang Y,Swing DA,Tessarollo L,Ji D,Jankowsky JL

更新日期：2016-07-19 00:00:00

abstract：:The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show a...

journal_title：Cell reports

authors： Dushukyan N,Dunn DM,Sager RA,Woodford MR,Loiselle DR,Daneshvar M,Baker-Williams AJ,Chisholm JD,Truman AW,Vaughan CK,Haystead TA,Bratslavsky G,Bourboulia D,Mollapour M

更新日期：2017-11-14 00:00:00

abstract：:DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed DNA methylation in skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of a subset of genes enriched in metabo...

journal_title：Cell reports

authors： Barres R,Kirchner H,Rasmussen M,Yan J,Kantor FR,Krook A,Näslund E,Zierath JR

更新日期：2013-04-25 00:00:00

abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...

journal_title：Cell reports

authors： Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

更新日期：2018-07-10 00:00:00

abstract：:The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a cri...

journal_title：Cell reports

authors： Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

更新日期：2018-05-01 00:00:00

abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

journal_title：Cell reports

authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

更新日期：2015-12-22 00:00:00

abstract：:Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit pr...

journal_title：Cell reports

authors： Yip SH,Romanò N,Gustafson P,Hodson DJ,Williams EJ,Kokay IC,Martin AO,Mollard P,Grattan DR,Bunn SJ

更新日期：2019-02-12 00:00:00

abstract：:In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...

journal_title：Cell reports

authors： Doucet YS,Woo SH,Ruiz ME,Owens DM

更新日期：2013-06-27 00:00:00

abstract：:Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activit...

journal_title：Cell reports

authors： Johnson SF,Cruz C,Greifenberg AK,Dust S,Stover DG,Chi D,Primack B,Cao S,Bernhardy AJ,Coulson R,Lazaro JB,Kochupurakkal B,Sun H,Unitt C,Moreau LA,Sarosiek KA,Scaltriti M,Juric D,Baselga J,Richardson AL,Rodig SJ,D

更新日期：2016-11-22 00:00:00

abstract：:Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in...

journal_title：Cell reports

authors： Bailly AP,Perrin A,Serrano-Macia M,Maghames C,Leidecker O,Trauchessec H,Martinez-Chantar ML,Gartner A,Xirodimas DP

更新日期：2019-10-01 00:00:00

abstract：:Accumulation of toxic amyloid oligomers is a key feature in the pathogenesis of amyloid-related diseases. Formation of mature amyloid fibrils is one defense mechanism to neutralize toxic prefibrillar oligomers. This mechanism is notably influenced by apolipoprotein E variants. Cells that produce mature amyloid fibrils...

journal_title：Cell reports

authors： van Niel G,Bergam P,Di Cicco A,Hurbain I,Lo Cicero A,Dingli F,Palmulli R,Fort C,Potier MC,Schurgers LJ,Loew D,Levy D,Raposo G

更新日期：2015-10-06 00:00:00

abstract：:While meta-analysis has demonstrated increased statistical power and more robust estimations in studies, the application of this commonly accepted methodology to cytometry data has been challenging. Different cytometry studies often involve diverse sets of markers. Moreover, the detected values of the same marker are ...

journal_title：Cell reports

authors： Hu Z,Jujjavarapu C,Hughey JJ,Andorf S,Lee HC,Gherardini PF,Spitzer MH,Thomas CG,Campbell J,Dunn P,Wiser J,Kidd BA,Dudley JT,Nolan GP,Bhattacharya S,Butte AJ

更新日期：2018-07-31 00:00:00

abstract：:There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical in...

journal_title：Cell reports

authors： Robbins N,Spitzer M,Yu T,Cerone RP,Averette AK,Bahn YS,Heitman J,Sheppard DC,Tyers M,Wright GD

更新日期：2015-11-17 00:00:00

abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...

journal_title：Cell reports

authors： Kobayashi H,Shoji K,Kiyokawa K,Negishi L,Tomari Y

更新日期：2019-07-30 00:00:00

abstract：:Emerging studies have begun to demonstrate that reprogrammed stromal cells play pivotal roles in tumor growth, metastasis, and resistance to therapy. However, the contribution of stromal cells to non-small-cell lung cancer (NSCLC) has remained underexplored. We used an orthotopic model of Kras-driven NSCLC to systemat...

journal_title：Cell reports

authors： Choi H,Sheng J,Gao D,Li F,Durrans A,Ryu S,Lee SB,Narula N,Rafii S,Elemento O,Altorki NK,Wong ST,Mittal V

更新日期：2015-02-24 00:00:00

abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

journal_title：Cell reports

authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

更新日期：2014-11-06 00:00:00

abstract：:Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn mo...

journal_title：Cell reports

authors： Senft AD,Costello I,King HW,Mould AW,Bikoff EK,Robertson EJ

更新日期：2018-08-21 00:00:00

abstract：:Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extr...

journal_title：Cell reports

authors： Zhao H,Michelot A,Koskela EV,Tkach V,Stamou D,Drubin DG,Lappalainen P

更新日期：2013-09-26 00:00:00

abstract：:Dietary nutrients interact with gene networks to orchestrate adaptive responses during metabolic stress. Here, we identify Baf60a as a diet-sensitive subunit of the SWI/SNF chromatin-remodeling complexes in the mouse liver that links the consumption of fat- and cholesterol-rich diet to elevated plasma cholesterol leve...

journal_title：Cell reports

authors： Meng ZX,Wang L,Chang L,Sun J,Bao J,Li Y,Chen YE,Lin JD

更新日期：2015-11-24 00:00:00

abstract：:It is known that plant cells can contain multiple distinct vacuoles; however, the abundance of multivacuolar cells and the mechanisms underlying vacuolar differentiation and communication among different types of vacuoles remain unknown. PH1 and PH5 are tonoplast P-ATPases that form a heteromeric pump that hyper-acidi...

journal_title：Cell reports

authors： Faraco M,Li Y,Li S,Spelt C,Di Sansebastiano GP,Reale L,Ferranti F,Verweij W,Koes R,Quattrocchio FM

更新日期：2017-06-20 00:00:00

abstract：:CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cisd2 haploinsufficiency causes a...

journal_title：Cell reports

authors： Shen ZQ,Chen YF,Chen JR,Jou YS,Wu PC,Kao CH,Wang CH,Huang YL,Chen CF,Huang TS,Shyu YC,Tsai SF,Kao LS,Tsai TF

更新日期：2017-11-21 00:00:00

abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...

journal_title：Cell reports

authors： Windmueller R,Leach JP,Babu A,Zhou S,Morley MP,Wakabayashi A,Petrenko NB,Viatour P,Morrisey EE

更新日期：2020-03-03 00:00:00

abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...

journal_title：Cell reports

authors： Duan Y,Zhang L,Angosto-Bazarra D,Pelegrín P,Núñez G,He Y

更新日期：2020-11-17 00:00:00

abstract：:Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) as an essential re...

journal_title：Cell reports

authors： Wang Y,Wang H,Guo J,Gao J,Wang M,Xia M,Wen Y,Su P,Yang M,Liu M,Shi L,Cheng T,Zhou W,Zhou J

更新日期：2020-05-05 00:00:00

abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...

journal_title：Cell reports

authors： Chen WW,Birsoy K,Mihaylova MM,Snitkin H,Stasinski I,Yucel B,Bayraktar EC,Carette JE,Clish CB,Brummelkamp TR,Sabatini DD,Sabatini DM

更新日期：2014-04-10 00:00:00

abstract：:Pancreatic β cells secrete insulin by Ca2+-triggered exocytosis. However, there is no apparent secretory site similar to the neuronal active zones, and the cellular and molecular localization mechanism underlying polarized exocytosis remains elusive. Here, we report that ELKS, a vertebrate active zone protein, is used...

journal_title：Cell reports

authors： Ohara-Imaizumi M,Aoyagi K,Yamauchi H,Yoshida M,Mori MX,Hida Y,Tran HN,Ohkura M,Abe M,Akimoto Y,Nakamichi Y,Nishiwaki C,Kawakami H,Hara K,Sakimura K,Nagamatsu S,Mori Y,Nakai J,Kakei M,Ohtsuka T

更新日期：2019-01-29 00:00:00

abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

journal_title：Cell reports

authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

更新日期：2020-08-11 00:00:00

abstract：:Cell size control emerges from a regulated balance between the rates of cell growth and division. In bacteria, simple quantitative laws connect cellular growth rate to ribosome abundance. However, it remains poorly understood how translation regulates bacterial cell size and shape under growth perturbations. Here, we ...

journal_title：Cell reports

authors： Serbanescu D,Ojkic N,Banerjee S

更新日期：2020-09-22 00:00:00