Abstract:
:The neural network of the temporal lobe is thought to provide a cognitive map of our surroundings. Functional analysis of this network has been hampered by coarse tools that often result in collateral damage to other circuits. We developed a chemogenetic system to temporally control electrical input into the hippocampus. When entorhinal input to the perforant path was acutely silenced, hippocampal firing patterns became destabilized and underwent extensive remapping. We also found that spatial memory acquired prior to neural silencing was impaired by loss of input through the perforant path. Together, our experiments show that manipulation of entorhinal activity destabilizes spatial coding and disrupts spatial memory. Moreover, we introduce a chemogenetic model for non-invasive neuronal silencing that offers multiple advantages over existing strategies in this setting.
journal_name
Cell Repjournal_title
Cell reportsauthors
Zhao R,Grunke SD,Keralapurath MM,Yetman MJ,Lam A,Lee TC,Sousounis K,Jiang Y,Swing DA,Tessarollo L,Ji D,Jankowsky JLdoi
10.1016/j.celrep.2016.06.032subject
Has Abstractpub_date
2016-07-19 00:00:00pages
793-804issue
3issn
2211-1247pii
S2211-1247(16)30772-0journal_volume
16pub_type
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