Abstract：
:Cell size control emerges from a regulated balance between the rates of cell growth and division. In bacteria, simple quantitative laws connect cellular growth rate to ribosome abundance. However, it remains poorly understood how translation regulates bacterial cell size and shape under growth perturbations. Here, we develop a whole-cell model for growth dynamics of rod-shaped bacteria that links ribosomal abundance with cell geometry, division control, and the extracellular environment. Our study reveals that cell size maintenance under nutrient perturbations requires a balanced trade-off between ribosomes and division protein synthesis. Deviations from this trade-off relationship are predicted under translation inhibition, leading to distinct modes of cell morphological changes, in agreement with single-cell experimental data on Escherichia coli. Furthermore, by calibrating our model with experimental data, we predict how combinations of nutrient-, translational-, and shape perturbations can be chosen to optimize bacterial growth fitness and antibiotic resistance.
journal_name
Cell Repjournal_title
Cell reportsauthors
Serbanescu D,Ojkic N,Banerjee Sdoi
10.1016/j.celrep.2020.108183subject
Has Abstractpub_date
2020-09-22 00:00:00pages
108183issue
12issn
2211-1247pii
S2211-1247(20)31172-4journal_volume
32pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.083
更新日期：2018-12-18 00:00:00
abstract：:Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response to physiological or pathological stress, prolonged hypertrophy can lead to heart failure. Here we demonstrate that Prdm16 is dispensable for...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108288
更新日期：2020-10-20 00:00:00
abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.079
更新日期：2018-03-20 00:00:00
abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108448
更新日期：2020-12-08 00:00:00
abstract：:Spatiotemporal protein reorganization at DNA damage sites induced by genotoxic chemotherapies is crucial for DNA damage response (DDR), which influences treatment response by directing cancer cell fate. This process is orchestrated by valosin-containing protein (VCP), an AAA+ ATPase that extracts polyubiquinated chrom...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107745
更新日期：2020-06-09 00:00:00
abstract：:The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the ERAD-associated ubiquitin l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107944
更新日期：2020-08-04 00:00:00
abstract：:Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed. We previously showed that downregulation of transcription by oncogenic Ras si...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.034
更新日期：2016-07-19 00:00:00
abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in nutrient homeostasis. GIP receptor (GIPR) is constitutively internalized and returned to the plasma membrane, atypical behavior for a G-protein-coupled receptor (GPCR). GIP promotes GIPR downregulation from the plasma membrane by inh...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.050
更新日期：2016-12-13 00:00:00
abstract：:Expansions of microsatellite repeats are responsible for numerous hereditary diseases in humans, including myotonic dystrophy and Friedreich's ataxia. Whereas the length of an expandable repeat is the main factor determining disease inheritance, recent data point to genomic trans modifiers that can impact the likeliho...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.08.051
更新日期：2017-09-05 00:00:00
abstract：:Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.009
更新日期：2018-02-27 00:00:00
abstract：:The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compound...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.013
更新日期：2013-07-11 00:00:00
abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.06.067
更新日期：2015-07-28 00:00:00
abstract：:Cytotoxic CD8(+) T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8(+) T cells home to virus-infected tissues. L-selectin has not been considered i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.12.090
更新日期：2016-02-02 00:00:00
abstract：:FBXL2 targets IP3R3 for ubiquitin-mediated degradation to limit Ca2+ flux to mitochondria and, consequently, apoptosis. Efficient replication of hepatitis C virus (HCV) requires geranylgeranylation of FBXL2. Here, we show that the viral protein NS5A forms a trimeric complex with IP3R3 and FBXL2, unmasking IP3R3's degr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.09.088
更新日期：2018-10-23 00:00:00
abstract：:TRBP functions as both a Dicer cofactor and a PKR inhibitor. However, the role of TRBP in microRNA (miRNA) biogenesis is controversial and its regulation of PKR in mitosis remains unexplored. Here, we generate TRBP knockout cells and find altered Dicer-processing sites in a subset of miRNAs but no effect on Dicer stab...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.09.039
更新日期：2014-11-06 00:00:00
abstract：:Complex interactions between immune cells are an important component in the induction of obesity. Here, we show that Il2rg-/-Rag2-/- mice lacking all lymphocytes are resistant to diet-induced obesity. Transplantation of bone marrow cells from Rag2-/- mice, which lack only acquired immune cells, into Il2rg-/-Rag2-/- mi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.06.016
更新日期：2019-07-02 00:00:00
abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.02.051
更新日期：2019-03-12 00:00:00
abstract：:Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity; still, however, they often mediate distinct functional...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.053
更新日期：2019-09-24 00:00:00
abstract：:The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. It was previously reported that Akt phosphorylates the mTORC2 subunit SIN1 at T86, activating mTORC2...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.016
更新日期：2015-08-11 00:00:00
abstract：:Accumulation of toxic amyloid oligomers is a key feature in the pathogenesis of amyloid-related diseases. Formation of mature amyloid fibrils is one defense mechanism to neutralize toxic prefibrillar oligomers. This mechanism is notably influenced by apolipoprotein E variants. Cells that produce mature amyloid fibrils...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.057
更新日期：2015-10-06 00:00:00
abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.034
更新日期：2020-03-03 00:00:00
abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.031
更新日期：2018-04-03 00:00:00
abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.089
更新日期：2020-02-25 00:00:00
abstract：:KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coen...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.07.009
更新日期：2016-08-09 00:00:00
abstract：:HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission, mediates resistance to immune responses, and facilitates the spread of virus among T cells. However, whether HIV cell-to-cell tra...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.07.079
更新日期：2018-08-21 00:00:00
abstract：:Metabolic reprogramming is a hallmark of clear cell renal cell carcinoma (ccRCC) progression. Here, we used genome-scale metabolic modeling to elucidate metabolic reprogramming in 481 ccRCC samples and discovered strongly coordinated regulation of glycosaminoglycan (GAG) biosynthesis at the transcript and protein leve...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.04.056
更新日期：2016-05-24 00:00:00
abstract：:Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these latter cellular responses require Rac-mediated remodeling of the actin cytoskeleton, we hypothesized that molecules involved in Rac activation ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.04.016
更新日期：2017-05-02 00:00:00
abstract：:RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations are known to originate in replication errors, difficulties of capturing the underlying dynamics have left the mechanochemical b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.01.031
更新日期：2015-02-17 00:00:00
abstract：:Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies sugg...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.01.009
更新日期：2013-02-21 00:00:00
abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.11.023
更新日期：2013-01-31 00:00:00
