当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model.

Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model.

Abstract：

:Emerging studies have begun to demonstrate that reprogrammed stromal cells play pivotal roles in tumor growth, metastasis, and resistance to therapy. However, the contribution of stromal cells to non-small-cell lung cancer (NSCLC) has remained underexplored. We used an orthotopic model of Kras-driven NSCLC to systematically dissect the contribution of specific hematopoietic stromal cells in lung cancer. RNA deep-sequencing analysis of individually sorted myeloid lineage and tumor epithelial cells revealed cell-type-specific differentially regulated genes, indicative of activated stroma. We developed a computational model for crosstalk signaling discovery based on ligand-receptor interactions and downstream signaling networks and identified known and novel tumor-stroma paracrine and tumor autocrine crosstalk-signaling pathways in NSCLC. We provide cellular and molecular insights into components of the lung cancer microenvironment that contribute to carcinogenesis. This study has the potential for development of therapeutic strategies that target tumor-stroma interactions and may complement conventional anti-cancer treatments.

journal_name

Cell Rep

journal_title

Cell reports

authors

Choi H,Sheng J,Gao D,Li F,Durrans A,Ryu S,Lee SB,Narula N,Rafii S,Elemento O,Altorki NK,Wong ST,Mittal V

doi

10.1016/j.celrep.2015.01.040

subject

Has Abstract

pub_date

2015-02-24 00:00:00

pages

1187-201

issue

7

issn

2211-1247

pii

S2211-1247(15)00065-0

journal_volume

10

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

    abstract：:Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function. Here, we show that loss of function of an ESCRT protein (HD-PTP encoded by the PTPN23 gene, located on the tumor suppressor gen...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.04.076

    authors： Manteghi S,Gingras MC,Kharitidi D,Galarneau L,Marques M,Yan M,Cencic R,Robert F,Paquet M,Witcher M,Pelletier J,Pause A

    更新日期：2016-05-31 00:00:00

  • Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

    abstract：:RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multipl...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.09.031

    authors： Zhu J,Davoli T,Perriera JM,Chin CR,Gaiha GD,John SP,Sigiollot FD,Gao G,Xu Q,Qu H,Pertel T,Sims JS,Smith JA,Baker RE,Maranda L,Ng A,Elledge SJ,Brass AL

    更新日期：2014-10-23 00:00:00

  • RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.

    abstract：:Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, espe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.11.010

    authors： Chandra V,Albagli-Curiel O,Hastoy B,Piccand J,Randriamampita C,Vaillant E,Cavé H,Busiah K,Froguel P,Vaxillaire M,Rorsman P,Polak M,Scharfmann R

    更新日期：2014-12-24 00:00:00

  • From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion.

    abstract：:Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans and mice. KCNH6 p.P235L hetero...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.005

    authors： Yang JK,Lu J,Yuan SS,Asan,Cao X,Qiu HY,Shi TT,Yang FY,Li Q,Liu CP,Wu Q,Wang YH,Huang HX,Kayoumu A,Feng JP,Xie RR,Zhu XR,Liu C,Yang GR,Zhang MR,Xie CL,Chen C,Zhang B,Liu G,Zhang XQ,Xu A

    更新日期：2018-12-26 00:00:00

  • Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.

    abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.109

    authors： Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM

    更新日期：2020-03-24 00:00:00

  • AMPK modulates tissue and organismal aging in a non-cell-autonomous manner.

    abstract：:AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impr...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.08.006

    authors： Ulgherait M,Rana A,Rera M,Graniel J,Walker DW

    更新日期：2014-09-25 00:00:00

  • Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1.

    abstract：:Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent kinase 1 (Cdk1) activates HR by phosphorylation of key recombination f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.11.044

    authors： Hentges P,Waller H,Reis CC,Ferreira MG,Doherty AJ

    更新日期：2014-12-24 00:00:00

  • Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

    abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.009

    authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

    更新日期：2013-01-31 00:00:00

  • Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells.

    abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107627

    authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

    更新日期：2020-05-12 00:00:00

  • EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.

    abstract：:Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate chol...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.01.020

    authors： Wanke F,Moos S,Croxford AL,Heinen AP,Gräf S,Kalt B,Tischner D,Zhang J,Christen I,Bruttger J,Yogev N,Tang Y,Zayoud M,Israel N,Karram K,Reißig S,Lacher SM,Reichhold C,Mufazalov IA,Ben-Nun A,Kuhlmann T,Wettschureck

    更新日期：2017-01-31 00:00:00

  • Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

    abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107839

    authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

    更新日期：2020-06-30 00:00:00

  • Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors.

    abstract：:Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.022

    authors： Tan PS,Aramburu IV,Mercadante D,Tyagi S,Chowdhury A,Spitz D,Shammas SL,Gräter F,Lemke EA

    更新日期：2018-03-27 00:00:00

  • Antibiotics Disrupt Coordination between Transcriptional and Phenotypic Stress Responses in Pathogenic Bacteria.

    abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.062

    authors： Jensen PA,Zhu Z,van Opijnen T

    更新日期：2017-08-15 00:00:00

  • 5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells.

    abstract：:5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, w...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.05.091

    authors： Nestor CE,Lentini A,Hägg Nilsson C,Gawel DR,Gustafsson M,Mattson L,Wang H,Rundquist O,Meehan RR,Klocke B,Seifert M,Hauck SM,Laumen H,Zhang H,Benson M

    更新日期：2016-07-12 00:00:00

  • Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response.

    abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.01.039

    authors： Lee KG,Kim SS,Kui L,Voon DC,Mauduit M,Bist P,Bi X,Pereira NA,Liu C,Sukumaran B,Rénia L,Ito Y,Lam KP

    更新日期：2015-02-24 00:00:00

  • Innate immune-directed NF-κB signaling requires site-specific NEMO ubiquitination.

    abstract：:While the I kappa kinase (IKK) scaffolding protein NF-κB essential modulator (NEMO) binds to polyubiquitin chains to transmit inflammatory signals, NEMO itself is also ubiquitinated in response to a variety of inflammatory agonists. Although there have been hints that polyubiquitination of NEMO is essential for avoidi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.036

    authors： Jun JC,Kertesy S,Jones MB,Marinis JM,Cobb BA,Tigno-Aranjuez JT,Abbott DW

    更新日期：2013-07-25 00:00:00

  • Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination.

    abstract：:Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothel...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.11.002

    authors： Hammond TR,McEllin B,Morton PD,Raymond M,Dupree J,Gallo V

    更新日期：2015-12-15 00:00:00

  • High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.

    abstract：:Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML), as these polyme...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.07.032

    authors： Zhao Y,Liu Q,Acharya P,Stengel KR,Sheng Q,Zhou X,Kwak H,Fischer MA,Bradner JE,Strickland SA,Mohan SR,Savona MR,Venters BJ,Zhou MM,Lis JT,Hiebert SW

    更新日期：2016-08-16 00:00:00

  • Sequence-dependent elongation dynamics on macrolide-bound ribosomes.

    abstract：:The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.034

    authors： Johansson M,Chen J,Tsai A,Kornberg G,Puglisi JD

    更新日期：2014-06-12 00:00:00

  • A Single Templating RNA in Yeast Telomerase.

    abstract：:The number of essential telomerase components in the active ribonucleoprotein (RNP) has important implications for its mechanism of action yet is by and large unknown. We report that two differentially tagged TLC1 RNAs endogenously expressed in a heterozygous diploid and simultaneously detected via multi-color fluores...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.06.045

    authors： Bajon E,Laterreur N,Wellinger RJ

    更新日期：2015-07-21 00:00:00

  • TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.

    abstract：:CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient exp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.061

    authors： Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W

    更新日期：2019-06-18 00:00:00

  • Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics.

    abstract：:Nuclear factor κB (NF-κB) RelA is the potent transcriptional activator of inflammatory response genes. We stringently defined a list of direct RelA target genes by integrating physical (chromatin immunoprecipitation sequencing [ChIP-seq]) and functional (RNA sequencing [RNA-seq] in knockouts) datasets. We then dissect...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.01.108

    authors： Ngo KA,Kishimoto K,Davis-Turak J,Pimplaskar A,Cheng Z,Spreafico R,Chen EY,Tam A,Ghosh G,Mitchell S,Hoffmann A

    更新日期：2020-02-25 00:00:00

  • HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.

    abstract：:The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.02.005

    authors： Weyn-Vanhentenryck SM,Mele A,Yan Q,Sun S,Farny N,Zhang Z,Xue C,Herre M,Silver PA,Zhang MQ,Krainer AR,Darnell RB,Zhang C

    更新日期：2014-03-27 00:00:00

  • Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.

    abstract：:Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes E...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.04.026

    authors： Howell KA,Qiu X,Brannan JM,Bryan C,Davidson E,Holtsberg FW,Wec AZ,Shulenin S,Biggins JE,Douglas R,Enterlein SG,Turner HL,Pallesen J,Murin CD,He S,Kroeker A,Vu H,Herbert AS,Fusco ML,Nyakatura EK,Lai JR,Keck ZY,

    更新日期：2016-05-17 00:00:00

  • The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

    abstract：:The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we ha...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.025

    authors： Mishima Y,Paiva B,Shi J,Park J,Manier S,Takagi S,Massoud M,Perilla-Glen A,Aljawai Y,Huynh D,Roccaro AM,Sacco A,Capelletti M,Detappe A,Alignani D,Anderson KC,Munshi NC,Prosper F,Lohr JG,Ha G,Freeman SS,Van Allen

    更新日期：2017-04-04 00:00:00

  • The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.

    abstract：:The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the primary cilium. Additionally, Shh controls axon guidance through a non-canonical...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.015

    authors： Ferent J,Constable S,Gigante ED,Yam PT,Mariani LE,Legué E,Liem KF Jr,Caspary T,Charron F

    更新日期：2019-12-10 00:00:00

  • Widespread Inhibition, Antagonism, and Synergy in Mouse Olfactory Sensory Neurons In Vivo.

    abstract：:Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but it remains unclear whether and how this occurs at the most peripheral level. Using in vivo calcium imaging of mouse olfactory bulb and olfactory epithelium in wild-type and mutant animals, we show that odors produce not only...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107814

    authors： Inagaki S,Iwata R,Iwamoto M,Imai T

    更新日期：2020-06-30 00:00:00

  • CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.

    abstract：:Trimethylation of histone H3 at lysine-4 (H3K4me3) is associated with eukaryotic gene promoters and poises their transcriptional activation during development. To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 his...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.011

    authors： Yu C,Fan X,Sha QQ,Wang HH,Li BT,Dai XX,Shen L,Liu J,Wang L,Liu K,Tang F,Fan HY

    更新日期：2017-08-01 00:00:00

  • Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

    abstract：:This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smoking and/or human papillomavirus (HPV). SCCs harbor 3q, 5p, and other recurrent chromosomal copy-number alterations (CNAs), DNA mutations...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.063

    authors： Campbell JD,Yau C,Bowlby R,Liu Y,Brennan K,Fan H,Taylor AM,Wang C,Walter V,Akbani R,Byers LA,Creighton CJ,Coarfa C,Shih J,Cherniack AD,Gevaert O,Prunello M,Shen H,Anur P,Chen J,Cheng H,Hayes DN,Bullman S,Ped

    更新日期：2018-04-03 00:00:00

  • ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

    abstract：:Despite the significance for fetal nourishment in mammals, mechanisms of umbilical cord vascular growth remain poorly understood. Here, the secreted metalloprotease ADAMTS9 is shown to be necessary for murine umbilical cord vascular development. Restricting it to the cell surface using a gene trap allele, Adamts9(Gt),...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.05.005

    authors： Nandadasa S,Nelson CM,Apte SS

    更新日期：2015-06-16 00:00:00