Abstract：
:Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7α,25-OHC. During EAE, we found increased expression of CH25H by microglia and CYP7B1 by CNS-infiltrating immune cells elevating the ligand concentration in the CNS. Two critical pro-inflammatory cytokines, interleukin-23 (IL-23) and interleukin-1 beta (IL-1β), maintained expression of EBI2 in differentiating Th17 cells. In line with this, EBI2 enhanced early migration of encephalitogenic T cells into the CNS in a transfer EAE model. Nonetheless, EBI2 was dispensable in active EAE. Human Th17 cells do also express EBI2, and EBI2 expressing cells are abundant within multiple sclerosis (MS) white matter lesions. These findings implicate EBI2 as a mediator of CNS autoimmunity and describe mechanistically its contribution to the migration of autoreactive T cells into inflamed organs.
journal_name
Cell Repjournal_title
Cell reportsauthors
Wanke F,Moos S,Croxford AL,Heinen AP,Gräf S,Kalt B,Tischner D,Zhang J,Christen I,Bruttger J,Yogev N,Tang Y,Zayoud M,Israel N,Karram K,Reißig S,Lacher SM,Reichhold C,Mufazalov IA,Ben-Nun A,Kuhlmann T,Wettschureckdoi
10.1016/j.celrep.2017.01.020subject
Has Abstractpub_date
2017-01-31 00:00:00pages
1270-1284issue
5issn
2211-1247pii
S2211-1247(17)30057-8journal_volume
18pub_type
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