Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.

abstract：:Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with various parameters of glucose homeostasis and susceptibility to type 2 diabete...

journal_title：Cell reports

authors： Wigger L,Cruciani-Guglielmacci C,Nicolas A,Denom J,Fernandez N,Fumeron F,Marques-Vidal P,Ktorza A,Kramer W,Schulte A,Le Stunff H,Liechti R,Xenarios I,Vollenweider P,Waeber G,Uphues I,Roussel R,Magnan C,Ibberson M,Th

更新日期：2017-02-28 00:00:00

abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...

journal_title：Cell reports

authors： Firth AL,Menon T,Parker GS,Qualls SJ,Lewis BM,Ke E,Dargitz CT,Wright R,Khanna A,Gage FH,Verma IM

更新日期：2015-09-01 00:00:00

abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...

journal_title：Cell reports

authors： Scholes C,Biette KM,Harden TT,DePace AH

更新日期：2019-02-26 00:00:00

abstract：:Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, the molecular events that predispose WAT to hypertrophy are poorly defined. Here, we demonstrate that adipocyte hypertrophy is triggered by loss of the corepressor GPS2 durin...

journal_title：Cell reports

authors： Drareni K,Ballaire R,Barilla S,Mathew MJ,Toubal A,Fan R,Liang N,Chollet C,Huang Z,Kondili M,Foufelle F,Soprani A,Roussel R,Gautier JF,Alzaid F,Treuter E,Venteclef N

更新日期：2018-09-11 00:00:00

abstract：:Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains unclear. We report here that the tRNA methyltransferase Dnmt2 is es...

journal_title：Cell reports

authors： Durdevic Z,Mobin MB,Hanna K,Lyko F,Schaefer M

更新日期：2013-09-12 00:00:00

abstract：:There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical in...

journal_title：Cell reports

authors： Robbins N,Spitzer M,Yu T,Cerone RP,Averette AK,Bahn YS,Heitman J,Sheppard DC,Tyers M,Wright GD

更新日期：2015-11-17 00:00:00

abstract：:Loss of metabolic homeostasis is a hallmark of aging and is commonly characterized by the deregulation of adaptive signaling interactions that coordinate energy metabolism with dietary changes. The mechanisms driving age-related changes in these adaptive responses remain unclear. Here, we characterize the deregulation...

journal_title：Cell reports

authors： Karpac J,Biteau B,Jasper H

更新日期：2013-09-26 00:00:00

abstract：:In Escherichia coli, bidirectional chromosomal replication is accompanied by the colocalization of sister replication forks. However, the biological significance of this mechanism and the key factors involved are still largely unknown. In this study, we found that a protein, termed CrfC, helps sustain the colocalizati...

journal_title：Cell reports

authors： Ozaki S,Matsuda Y,Keyamura K,Kawakami H,Noguchi Y,Kasho K,Nagata K,Masuda T,Sakiyama Y,Katayama T

更新日期：2013-09-12 00:00:00

abstract：:Hedgehog (Hh) signaling plays an integral role in vertebrate development, and its dysregulation has been accepted widely as a driver of numerous malignancies. While a variety of small molecules target Smoothened (Smo) as a strategy for Hh inhibition, Smo gain-of-function mutations have limited their clinical implement...

journal_title：Cell reports

authors： Williams CH,Hempel JE,Hao J,Frist AY,Williams MM,Fleming JT,Sulikowski GA,Cooper MK,Chiang C,Hong CC

更新日期：2015-04-07 00:00:00

abstract：:Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...

journal_title：Cell reports

authors： Olson OC,Kim H,Quail DF,Foley EA,Joyce JA

更新日期：2017-04-04 00:00:00

abstract：:The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...

journal_title：Cell reports

authors： Korotkova DD,Lyubetsky VA,Ivanova AS,Rubanov LI,Seliverstov AV,Zverkov OA,Martynova NY,Nesterenko AM,Tereshina MB,Peshkin L,Zaraisky AG

更新日期：2019-10-22 00:00:00

abstract：:The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylat...

journal_title：Cell reports

authors： Mandoli A,Singh AA,Prange KHM,Tijchon E,Oerlemans M,Dirks R,Ter Huurne M,Wierenga ATJ,Janssen-Megens EM,Berentsen K,Sharifi N,Kim B,Matarese F,Nguyen LN,Hubner NC,Rao NA,van den Akker E,Altucci L,Vellenga E,Stunnenb

更新日期：2016-11-15 00:00:00

abstract：:The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compound...

journal_title：Cell reports

authors： Garcia H,Miecznikowski JC,Safina A,Commane M,Ruusulehto A,Kilpinen S,Leach RW,Attwood K,Li Y,Degan S,Omilian AR,Guryanova O,Papantonopoulou O,Wang J,Buck M,Liu S,Morrison C,Gurova KV

更新日期：2013-07-11 00:00:00

abstract：:Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the relative levels of proteins in diploid S. pombe cells during meiosi...

journal_title：Cell reports

authors： Krapp A,Hamelin R,Armand F,Chiappe D,Krapp L,Cano E,Moniatte M,Simanis V

更新日期：2019-01-22 00:00:00

abstract：:Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized mechanism of transcription interference. Here, we propose a comprehensive model ...

journal_title：Cell reports

authors： Gill JK,Maffioletti A,García-Molinero V,Stutz F,Soudet J

更新日期：2020-05-05 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell-targeting immunotherapies. We demonstrate that I...

journal_title：Cell reports

authors： Holmgaard RB,Zamarin D,Li Y,Gasmi B,Munn DH,Allison JP,Merghoub T,Wolchok JD

更新日期：2015-10-13 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition an...

journal_title：Cell reports

authors： Skelly DA,Squiers GT,McLellan MA,Bolisetty MT,Robson P,Rosenthal NA,Pinto AR

更新日期：2018-01-16 00:00:00

abstract：:Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extr...

journal_title：Cell reports

authors： Zhao H,Michelot A,Koskela EV,Tkach V,Stamou D,Drubin DG,Lappalainen P

更新日期：2013-09-26 00:00:00

abstract：:Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

journal_title：Cell reports

authors： Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

更新日期：2019-07-30 00:00:00

abstract：:Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (AP...

journal_title：Cell reports

authors： Park G,Nhan HS,Tyan SH,Kawakatsu Y,Zhang C,Navarro M,Koo EH

更新日期：2020-06-30 00:00:00

abstract：:Trithorax proteins and long-intergenic noncoding RNAs are critical regulators of embryonic stem cell pluripotency; however, how they cooperatively regulate germ layer mesoderm specification remains elusive. We report here that HoxBlinc RNA first specifies Flk1(+) mesoderm and then promotes hematopoietic differentiatio...

journal_title：Cell reports

authors： Deng C,Li Y,Zhou L,Cho J,Patel B,Terada N,Li Y,Bungert J,Qiu Y,Huang S

更新日期：2016-01-05 00:00:00

abstract：:Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

journal_title：Cell reports

authors： Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

更新日期：2014-04-10 00:00:00

abstract：:The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key role in this decision by promoting the proliferative, undifferentiated ...

journal_title：Cell reports

authors： Lou CH,Shao A,Shum EY,Espinoza JL,Huang L,Karam R,Wilkinson MF

更新日期：2014-02-27 00:00:00

abstract：:We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked inhibitor of apoptosis). ARTS and Bcl-2 reside at the outer mitochondrial m...

journal_title：Cell reports

authors： Edison N,Curtz Y,Paland N,Mamriev D,Chorubczyk N,Haviv-Reingewertz T,Kfir N,Morgenstern D,Kupervaser M,Kagan J,Kim HT,Larisch S

更新日期：2017-10-10 00:00:00

abstract：:The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in t...

journal_title：Cell reports

authors： Cunningham TJ,Zhao X,Sandell LL,Evans SM,Trainor PA,Duester G

更新日期：2013-05-30 00:00:00

abstract：:The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null allele, whereas the other (RAD50E1035Δ) leads to the loss of a single residu...

journal_title：Cell reports

authors： Chansel-Da Cruz M,Hohl M,Ceppi I,Kermasson L,Maggiorella L,Modesti M,de Villartay JP,Ileri T,Cejka P,Petrini JHJ,Revy P

更新日期：2020-12-29 00:00:00

abstract：:ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. We report here that ACL silencing impairs myoblast and satellite cell (SC) differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD. Conver...

journal_title：Cell reports

authors： Das S,Morvan F,Morozzi G,Jourde B,Minetti GC,Kahle P,Rivet H,Brebbia P,Toussaint G,Glass DJ,Fornaro M

更新日期：2017-12-12 00:00:00

abstract：:Autism spectrum disorders (ASDs) are associated with mutations affecting synaptic components, including GluN2B-NMDA receptors (NMDARs) and neurobeachin (NBEA). NBEA participates in biosynthetic pathways to regulate synapse receptor targeting, synaptic function, cognition, and social behavior. However, the role of NBEA...

journal_title：Cell reports

authors： Gromova KV,Muhia M,Rothammer N,Gee CE,Thies E,Schaefer I,Kress S,Kilimann MW,Shevchuk O,Oertner TG,Kneussel M

更新日期：2018-05-29 00:00:00

abstract：:Sensory processing can be tuned by a neuron's integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the pos...

journal_title：Cell reports

authors： Yu WQ,El-Danaf RN,Okawa H,Pacholec JM,Matti U,Schwarz K,Odermatt B,Dunn FA,Lagnado L,Schmitz F,Huberman AD,Wong ROL

更新日期：2018-11-20 00:00:00