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Synaptic Convergence Patterns onto Retinal Ganglion Cells Are Preserved despite Topographic Variation in Pre- and Postsynaptic Territories.

Abstract：

:Sensory processing can be tuned by a neuron's integration area, the types of inputs, and the proportion and number of connections with those inputs. Integration areas often vary topographically to sample space differentially across regions. Here, we highlight two visual circuits in which topographic changes in the postsynaptic retinal ganglion cell (RGC) dendritic territories and their presynaptic bipolar cell (BC) axonal territories are either matched or unmatched. Despite this difference, in both circuits, the proportion of inputs from each BC type, i.e., synaptic convergence between specific BCs and RGCs, remained constant across varying dendritic territory sizes. Furthermore, synapse density between BCs and RGCs was invariant across topography. Our results demonstrate a wiring design, likely engaging homotypic axonal tiling of BCs, that ensures consistency in synaptic convergence between specific BC types onto their target RGCs while enabling independent regulation of pre- and postsynaptic territory sizes and synapse number between cell pairs.

journal_name

Cell Rep

journal_title

Cell reports

authors

Yu WQ,El-Danaf RN,Okawa H,Pacholec JM,Matti U,Schwarz K,Odermatt B,Dunn FA,Lagnado L,Schmitz F,Huberman AD,Wong ROL

doi

10.1016/j.celrep.2018.10.089

subject

Has Abstract

pub_date

2018-11-20 00:00:00

pages

2017-2026.e3

issue

8

issn

2211-1247

pii

S2211-1247(18)31693-0

journal_volume

25

pub_type

杂志文章

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