Abstract:
:The casein kinase 1 (CK1) family participates in various cellular processes in eukaryotes, but CK1 function in higher plants remains largely unknown. Here, we characterize the function of Arabidopsis CK1 in the regulation of ethylene biosynthesis. Etiolated seedlings of a CK1.8-deficient mutant, ck1.8-1, showed characteristic ethylene-specific constitutive responses due to overaccumulation of ethylene. Biochemical and physiological studies showed that CK1.8 phosphorylates ACS5, a key enzyme of ethylene biosynthesis, at threonine 463 to promote its interaction with the E3 ubiquitin ligase Ethylene Overproduction 1 (ETO1). Deficiency of CK1.8 leads to the accumulation of ACS5, and transgenic plants harboring a dephosphorylation-mimic ACS5(T463A) showed constitutive ethylene responses, confirming the role of CK1.8 in regulating ACS5 stability by phosphorylation and demonstrating that CK1.8 is an important regulator of ethylene biosynthesis. CK1.8 expression is feedback regulated by ethylene. Our studies provide insight into the regulation of ACS5 and ethylene biosynthesis.
journal_name
Cell Repjournal_title
Cell reportsauthors
Tan ST,Xue HWdoi
10.1016/j.celrep.2014.10.047subject
Has Abstractpub_date
2014-12-11 00:00:00pages
1692-1702issue
5issn
2211-1247pii
S2211-1247(14)00916-4journal_volume
9pub_type
杂志文章相关文献
Cell Reports文献大全abstract::Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property chan...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.02.022
更新日期:2020-03-03 00:00:00
abstract::Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.029
更新日期:2018-01-02 00:00:00
abstract::The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.04.040
更新日期:2017-05-09 00:00:00
abstract::The dynamic interactions between synaptic excitation and inhibition (E/I) shape membrane potential fluctuations and determine patterns of neuronal outputs; however, the spatiotemporal organization of these interactions within a single cell is poorly understood. Here, we investigated the relationship between local syna...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.01.024
更新日期:2016-02-16 00:00:00
abstract::In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.04.026
更新日期:2013-06-27 00:00:00
abstract::Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108532
更新日期:2021-01-05 00:00:00
abstract::Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.11.018
更新日期:2015-12-22 00:00:00
abstract::Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis. Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.02.001
更新日期:2017-02-21 00:00:00
abstract::To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.04.020
更新日期:2019-07-09 00:00:00
abstract::Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.05.036
更新日期:2014-07-10 00:00:00
abstract::Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibition triggers ubiqu...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.05.078
更新日期:2017-06-20 00:00:00
abstract::Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone i...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108047
更新日期:2020-08-18 00:00:00
abstract::The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2017.12.105
更新日期:2018-01-30 00:00:00
abstract::Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit neutralizing responses against HIV-1 strains closely related to the immunizing trimer. However, to date such stabilization has succeeded with only a limited number of HIV-1 strains. To address this issue, here we develop ADROITri...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.108432
更新日期:2020-11-24 00:00:00
abstract::Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature to undergo glucose-stimulated insulin secretion, but molecular regulation of thi...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2020.107687
更新日期:2020-05-26 00:00:00
abstract::BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached t...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.11.063
更新日期:2016-12-20 00:00:00
abstract::The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their inner...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.02.016
更新日期:2015-03-10 00:00:00
abstract::Insulin-stimulated hepatic glycogen synthesis is central to glucose homeostasis. Here, we show that PPP1R3G, a regulatory subunit of protein phosphatase 1 (PP1), is directly phosphorylated by AKT. PPP1R3G phosphorylation fluctuates with fasting-refeeding cycle and is required for insulin-stimulated dephosphorylation, ...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.08.066
更新日期:2019-09-24 00:00:00
abstract::Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.04.017
更新日期:2018-05-08 00:00:00
abstract::Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.10.077
更新日期:2019-11-26 00:00:00
abstract::The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3), leading to aberrant gene transcri...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.04.004
更新日期:2015-05-05 00:00:00
abstract::Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine,...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.02.009
更新日期:2016-03-08 00:00:00
abstract::Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.05.042
更新日期:2019-06-11 00:00:00
abstract::Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phospho...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.12.003
更新日期:2014-01-16 00:00:00
abstract::Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2018.03.066
更新日期:2018-04-10 00:00:00
abstract::The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2014.05.015
更新日期:2014-06-26 00:00:00
abstract::The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phosp...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2019.09.040
更新日期:2019-10-22 00:00:00
abstract::BAF (Brg/Brm-associated factors) complexes play important roles in development and are linked to chromatin plasticity at selected genomic loci. Nevertheless, a full understanding of their role in development and chromatin remodeling has been hindered by the absence of mutants completely lacking BAF complexes. Here, we...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2015.10.046
更新日期:2015-12-01 00:00:00
abstract::Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2013.10.050
更新日期:2013-12-12 00:00:00
abstract::Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currently being developed t...
journal_title:Cell reports
pub_type: 杂志文章
doi:10.1016/j.celrep.2016.11.073
更新日期:2016-12-20 00:00:00