当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.

Abstract：

:T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces Th17 cell differentiation while stress inducers enhance the development of Th17 cells. The cellular stress response results in Th17 cell development via sustained cytoplasmic calcium levels and, in part, XBP1 activity. Furthermore, in an inflammatory environment, conditions resulting in cell stress can bring about de novo Th17 cell differentiation, even in the absence of transforming growth factor β (TGF-β) signaling. In vivo, cell stress inhibition enhances resistance to Th17-mediated autoimmunity while stress-exposed T cells enhance disease severity. Adverse metabolic environments during inflammation provide a link between adaptive immunity and inflammation and may represent a risk factor for the development of chronic inflammatory conditions by facilitating Th17 cell differentiation.

journal_name

Cell Rep

journal_title

Cell reports

authors

Brucklacher-Waldert V,Ferreira C,Stebegg M,Fesneau O,Innocentin S,Marie JC,Veldhoen M

doi

10.1016/j.celrep.2017.05.052

subject

Has Abstract

pub_date

2017-06-13 00:00:00

pages

2357-2370

issue

11

issn

2211-1247

pii

S2211-1247(17)30709-X

journal_volume

19

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

    abstract：:Cell-cycle arrest in quiescence and senescence is largely orchestrated by the retinoblastoma (Rb) tumor-suppressor pathway, but the mechanisms underlying the quiescence-senescence switch remain unclear. Here, we show that the crosstalk between the Rb-AKT-signaling pathways forms this switch by controlling the overlapp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.03.006

    authors： Imai Y,Takahashi A,Hanyu A,Hori S,Sato S,Naka K,Hirao A,Ohtani N,Hara E

    更新日期：2014-04-10 00:00:00

  • Distinct Polymorphisms in HLA Class I Molecules Govern Their Susceptibility to Peptide Editing by TAPBPR.

    abstract：:Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer, and autoinflammatory conditions. Although the intracellular chaperone TAPBPR...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.09.074

    authors： Ilca FT,Drexhage LZ,Brewin G,Peacock S,Boyle LH

    更新日期：2019-11-05 00:00:00

  • Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.

    abstract：:Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histone crosstalk pathway...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.058

    authors： Anderson CJ,Baird MR,Hsu A,Barbour EH,Koyama Y,Borgnia MJ,McGinty RK

    更新日期：2019-02-12 00:00:00

  • Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples.

    abstract：:Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5-15 Hz) sharp-wave, a high-frequency "ripple" os...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.066

    authors： Oliva A,Fernández-Ruiz A,Fermino de Oliveira E,Buzsáki G

    更新日期：2018-11-13 00:00:00

  • RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice.

    abstract：:RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood. Here, we generated Ripk3 mutant mice by altering the RIPK3 kinase...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.04.011

    authors： Zhao Q,Yu X,Zhang H,Liu Y,Zhang X,Wu X,Xie Q,Li M,Ying H,Zhang H

    更新日期：2017-04-25 00:00:00

  • SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome.

    abstract：:SUMOylation is the covalent conjugation of SUMO polypeptides to cellular target proteins. Psmd1 is a subunit of the proteasomal 19S regulatory particle that acts as a docking site for Adrm1, another proteasome subunit that recruits ubiquitinated substrates for proteolysis. Here, we show that the SUMO deconjugating enz...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.009

    authors： Ryu H,Gygi SP,Azuma Y,Arnaoutov A,Dasso M

    更新日期：2014-06-26 00:00:00

  • A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring.

    abstract：:Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which is increased in diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), which when mutated is associated with neurodevelopmental disorders. S...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.067

    authors： Yang G,Cancino GI,Zahr SK,Guskjolen A,Voronova A,Gallagher D,Frankland PW,Kaplan DR,Miller FD

    更新日期：2016-10-18 00:00:00

  • Orthogonal Dietary Niche Enables Reversible Engraftment of a Gut Bacterial Commensal.

    abstract：:Interest in manipulating the gut microbiota to treat disease has led to a need for understanding how organisms can establish themselves when introduced into a host with an intact microbial community. Here, we employ the concept of orthogonal niche engineering: a resource typically absent from the diet, seaweed, create...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.032

    authors： Kearney SM,Gibbons SM,Erdman SE,Alm EJ

    更新日期：2018-08-14 00:00:00

  • Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity.

    abstract：:The conserved NAD+-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demonstrated that the dom...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.012

    authors： Deota S,Chattopadhyay T,Ramachandran D,Armstrong E,Camacho B,Maniyadath B,Fulzele A,Gonzalez-de-Peredo A,Denu JM,Kolthur-Seetharam U

    更新日期：2017-03-28 00:00:00

  • Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins.

    abstract：:Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease pat...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.036

    authors： Iversen R,Snir O,Stensland M,Kroll JE,Steinsbø Ø,Korponay-Szabó IR,Lundin KEA,de Souza GA,Sollid LM

    更新日期：2017-09-05 00:00:00

  • Conservation of mRNA and protein expression during development of C. elegans.

    abstract：:Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the correlation between mRNA and protein abundance during development is...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.001

    authors： Grün D,Kirchner M,Thierfelder N,Stoeckius M,Selbach M,Rajewsky N

    更新日期：2014-02-13 00:00:00

  • Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.

    abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.039

    authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

    更新日期：2014-11-20 00:00:00

  • Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

    abstract：:MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, the mechanisms whereby miRNAs are sorted to exosomes and the significance of miRNA transfer to acceptor cells are unclear. We used macrophage...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.07.035

    authors： Squadrito ML,Baer C,Burdet F,Maderna C,Gilfillan GD,Lyle R,Ibberson M,De Palma M

    更新日期：2014-09-11 00:00:00

  • Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

    abstract：:The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.03.036

    authors： Cunningham TJ,Zhao X,Sandell LL,Evans SM,Trainor PA,Duester G

    更新日期：2013-05-30 00:00:00

  • Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.

    abstract：:Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.04.058

    authors： Weber MM,Lam JL,Dooley CA,Noriea NF,Hansen BT,Hoyt FH,Carmody AB,Sturdevant GL,Hackstadt T

    更新日期：2017-05-16 00:00:00

  • Host AMPK Is a Modulator of Plasmodium Liver Infection.

    abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.001

    authors： Ruivo MTG,Vera IM,Sales-Dias J,Meireles P,Gural N,Bhatia SN,Mota MM,Mancio-Silva L

    更新日期：2016-09-06 00:00:00

  • RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.

    abstract：:CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA regulation. However, the relationship between target RNA binding and HEPN (higher eukaryotes and prokaryotes nucleotide binding) domain nuclease activation is poorl...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.06.105

    authors： Tambe A,East-Seletsky A,Knott GJ,Doudna JA,O'Connell MR

    更新日期：2018-07-24 00:00:00

  • Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.

    abstract：:Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108562

    authors： Patananan AN,Sercel AJ,Wu TH,Ahsan FM,Torres A Jr,Kennedy SAL,Vandiver A,Collier AJ,Mehrabi A,Van Lew J,Zakin L,Rodriguez N,Sixto M,Tadros W,Lazar A,Sieling PA,Nguyen TL,Dawson ER,Braas D,Golovato J,Cisneros L,V

    更新日期：2020-12-29 00:00:00

  • Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

    abstract：:Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.005

    authors： Erdel F,Kratz K,Willcox S,Griffith JD,Greene EC,de Lange T

    更新日期：2017-01-03 00:00:00

  • Hybridization reveals the evolving genomic architecture of speciation.

    abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.09.042

    authors： Kronforst MR,Hansen ME,Crawford NG,Gallant JR,Zhang W,Kulathinal RJ,Kapan DD,Mullen SP

    更新日期：2013-11-14 00:00:00

  • LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.

    abstract：:LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 precursors (pre-let-7) by promoting oligouridylation by terminal ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.044

    authors： Wang L,Nam Y,Lee AK,Yu C,Roth K,Chen C,Ransey EM,Sliz P

    更新日期：2017-03-14 00:00:00

  • Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.

    abstract：:Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107998

    authors： Henriques F,Bedard AH,Guilherme A,Kelly M,Chi J,Zhang P,Lifshitz LM,Bellvé K,Rowland LA,Yenilmez B,Kumar S,Wang Y,Luban J,Weinstein LS,Lin JD,Cohen P,Czech MP

    更新日期：2020-08-04 00:00:00

  • Tumor suppression by p53: is apoptosis important or not?

    abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...

    journal_title：Cell reports

    pub_type： 评论,杂志文章

    doi：10.1016/j.celrep.2013.05.011

    authors： Mellert H,Espinosa JM

    更新日期：2013-05-30 00:00:00

  • CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.

    abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108531

    authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

    更新日期：2020-12-22 00:00:00

  • Investigation of Proteomic and Phosphoproteomic Responses to Signaling Network Perturbations Reveals Functional Pathway Organizations in Yeast.

    abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.10.034

    authors： Li J,Paulo JA,Nusinow DP,Huttlin EL,Gygi SP

    更新日期：2019-11-12 00:00:00

  • The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells.

    abstract：:Natural killer (NK) cells possess potent cytotoxic mechanisms that need to be tightly controlled. Here, we explored the regulation and function of GPR56/ADGRG1, an adhesion G protein-coupled receptor implicated in developmental processes and expressed distinctively in mature NK cells. Expression of GPR56 was triggered...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.04.053

    authors： Chang GW,Hsiao CC,Peng YM,Vieira Braga FA,Kragten NA,Remmerswaal EB,van de Garde MD,Straussberg R,König GM,Kostenis E,Knäuper V,Meyaard L,van Lier RA,van Gisbergen KP,Lin HH,Hamann J

    更新日期：2016-05-24 00:00:00

  • Reduced peroxisomal import triggers peroxisomal retrograde signaling.

    abstract：:Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that pe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108653

    authors： Rackles E,Witting M,Forné I,Zhang X,Zacherl J,Schrott S,Fischer C,Ewbank JJ,Osman C,Imhof A,Rolland SG

    更新日期：2021-01-19 00:00:00

  • ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells.

    abstract：:Pancreatic β cells secrete insulin by Ca2+-triggered exocytosis. However, there is no apparent secretory site similar to the neuronal active zones, and the cellular and molecular localization mechanism underlying polarized exocytosis remains elusive. Here, we report that ELKS, a vertebrate active zone protein, is used...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.12.106

    authors： Ohara-Imaizumi M,Aoyagi K,Yamauchi H,Yoshida M,Mori MX,Hida Y,Tran HN,Ohkura M,Abe M,Akimoto Y,Nakamichi Y,Nishiwaki C,Kawakami H,Hara K,Sakimura K,Nagamatsu S,Mori Y,Nakai J,Kakei M,Ohtsuka T

    更新日期：2019-01-29 00:00:00

  • Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.

    abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.109

    authors： Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM

    更新日期：2020-03-24 00:00:00

  • Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

    abstract：:Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.001

    authors： Wang Y,Xu X,Maglic D,Dill MT,Mojumdar K,Ng PK,Jeong KJ,Tsang YH,Moreno D,Bhavana VH,Peng X,Ge Z,Chen H,Li J,Chen Z,Zhang H,Han L,Du D,Creighton CJ,Mills GB,Cancer Genome Atlas Research Network.,Camargo F,Liang

    更新日期：2018-10-30 00:00:00